I wonder if body builders using creatine get less cancer

[Graham49]

J Exp Med. 2019 Dec 2;216(12):2869-2882. doi: 10.1084/jem.20182044. Epub 2019 Oct 18.

Creatine uptake regulates CD8 T cell antitumor immunity.

Di Biase S#1, Ma X#1, Wang X1, Yu J1, Wang YC1, Smith DJ1, Zhou Y1, Li Z1, Kim YJ1, Clarke N1, To A1, Yang L2,3,4,5.

Author information

Abstract

T cells demand massive energy to combat cancer; however, the metabolic regulators controlling antitumor T cell immunity have just begun to be unveiled. When studying nutrient usage of tumor-infiltrating immune cells in mice, we detected a sharp increase of the expression of a CrT (Slc6a8) gene, which encodes a surface transporter controlling the uptake of creatine into a cell. Using CrT knockout mice, we showed that creatine uptake deficiency severely impaired antitumor T cell immunity. Supplementing creatine to WT mice significantly suppressed tumor growth in multiple mouse tumor models, and the combination of creatine supplementation with a PD-1/PD-L1 blockade treatment showed synergistic tumor suppression efficacy. We further demonstrated that creatine acts as a "molecular battery" conserving bioenergy to power T cell activities. Therefore, our results have identified creatine as an important metabolic regulator controlling antitumor T cell immunity, underscoring the potential of creatine supplementation to improve T cell-based cancer immunotherapies.

© 2019 Di Biase et al.

PMID: 31628186 PMCID: PMC6888972 DOI: 10.1084/jem.20182044

[rocket09]

Great , Thanks.

[keepinon]

I am on about month 10 of Lupron +Z+P. I lift weights 3 times a week and have been able to maintain most of my strength but my arms have become the arms of a skinny 12 year old. In your opinion would creatine be a good thing to add?

[Kuanyin]

I think this is a two-fer: help conserve muscle mass while building up immunity. I have sent a copy of the article to my MO to see whether or not their might me a downside, at least for my particular situation.

--K

[GeorgeGlass in reply to Kuanyin]

What did your ammo have to say?

[Kuanyin in reply to GeorgeGlass]

Hi George,

He offered no objections. Actually, it was my own concerns that led me to not take it. My two concerns are (1) it would increase my blood creatinine which is a measure of kidney function--in other words taking creatine might mask a kidney problem (Creatinine clearance (CrCl) is the volume of blood plasma cleared of creatinine per unit time. It is a rapid and cost-effective method for the measurement of renal function. Both CrCl and GFR can be measured using the comparative values of creatinine in blood and urine. Glomerular Filtration Rate.); (2) I am 81, what results can I seriously look forward to? Going to the gym, up until now, three times a week was sufficient to maintain functional strength, anything else, I have my weight-training son to assist.

--K.

[GeorgeGlass in reply to Kuanyin]

Make sense. Thanks K. My creatinine test came back today. It was on the lowest possible number in the normal range. Thus, I think I have some leeway room to take 5mg a day and see how it goes. I need a little more iron and zinc too. Good that you and your son are working out together. Nice.

George

[keepinon]

Thanks for the reply. I will probably pass on it for now. Taking enough stuff already.

[dentaltwin]

Ahh, creatine (AKA "Krebiozen")--I'm getting a flashback to my youth!

en.wikipedia.org/wiki/Krebi...

[GeorgeGlass]

Has anyone discovered any new info on adding creatine? Will it change a1c and blood glucose levels? Did the MO have an opinion? Is anyone using while on adt?

[GeorgeGlass]

Nalakrats, do you see any issue with taking creatine while on ADT?