I have been on Lupron for 10 1/2 months and have tolerated it reasonably well. Obvious testicular atrophy and new belly fat past 2 months. For a few days I have had what feels like a symmetric severe sunburn with quite painful constant skin-superficial sq stinging but no redness or rash. It hurts to move. It feels better in a hot bath. First was across upper abdomen and I thought I had strained now weak abdominal muscles transplanting some trees the day before. But that largely resolved in 3-4 days and the stinging soreness moved to across my chest and under the arms, resolved and moved to a band at suprapubic-lower abdomen and lower back and persisting. I had some finger numbness and leg cramps for a couple of days too, now better. A late Lupron effect? Hypocalcemia? (labs normal last month). ??
Context: see Profile, G9 oligometastatic low-volume HSPC diagnosed 1/2019, treated with ADT, EBRT including 1cm R sacral lesion and all pelvic nodes, HD Brachytherapy with adjuvant hyperthermia, SBRT to indeterminate 3mm L rib lesion. A 0.7cm defined L sacral lesion not seen on bone scan was not radiated. All 3 bone lesions were negative on staging Axumin. PSA 9.2 at diagnosis, < 0.1 “undetectable” since June completion of radiation, total testosterone 10. Alk Phos 70s all along . Addition of Zytiga advised after radiation but judged contraindicated because I was liver toxic from 3 months of initial bicalutamide, took 5 months to normalize LFTs. Had major liver consult and work-up. Just approved for apalutamide as less likely liver toxic, haven’t started it. F/u bone scan after 9 months ADT was negative, f/u CT read both the sacral and ilium lesions as “unchanged”.
Radiation and diarrhea/ GI issues/ please help 
Improved chances of success with ADT?
Five years later
Irrational emotional mood swings on ADT
