I saw this article today so i translated from swedish to english ----Thnx google---- very helpful.....!
Mice that lived in room temperatures of 4 degrees had significantly slower tumor growth. They lived almost twice as long, compared to mice that were in rooms with 30 degrees.
The inhibitory effect disappeared when the researchers removed the protein crucial to the metabolism of the brown fat, and also when the mice were given a high-sugar drink.
A high intake of sugar thus appears to destroy the beneficial effect of cold temperatures.
"More time and effect"
Similar metabolic mechanisms were seen in a person who had started chemotherapy and who stayed coolly dressed in a room at 22 degrees.
The hope is that it will work on all types of cancer, even difficult-to-treat variants such as liver cancer and pancreatic cancer.
- We hope that cold therapy and activation of brown fat tissue can be combined with other treatment methods and drugs, and give more time and effect for other methods, says Yihai Cao.
The next step is a larger clinical study on humans.
- Then we will see if this has a real effect on people. That's the dream.
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As temperature increases so do the rate of enzyme reactions. A ten degree centigrade rise in temperature will increase the activity of most enzymes by 50% to 100%. Variations in reaction temperature as small as 1 or 2 degrees may introduce changes of 10% to 20% in the results. This increase is only up to a certain point until the elevated temperature breaks the structure of the enzyme. Once the enzyme is denatured, it cannot be repaired. As each enzyme is different in its structure and bonds between amino acids and peptides, the temperature for denaturing is specific for each enzyme. Because most animal enzymes rapidly become denatured at temperatures above 40°C, most enzyme determinations are carried out somewhat below that temperature.
Effect of Temperature on Enzymatic ReactionFigure 1. Effect of temperature on reaction rate.
Over a period of time, enzymes will be deactivated at even moderate temperatures. Storage of enzymes at 5°C or below is generally the most suitable. Lower temperatures lead to slower chemical reactions. Enzymes will eventually become inactive at freezing temperatures but will restore most of their enzyme activity when temperatures increase again, while some enzymes lose their activity when frozen.
I believe low body slows enzymatic processes down ehich can easily be seen in slow metabolism and hypothyroidism.
I don't know what pathways they are targeting or what the method of action is in this protocol, but most enzymatic / cellular activity slows at lower temps, that is why we store food in fridges. 4 degrees C is your fridge temp and I would last about hour and that would be the end of me. Interesting to see how they would implement this in humans
"When the researchers removed either the brown fat or a protein crucial for its metabolism called UCP1, the beneficial effect of the cold exposure was essentially wiped out and the tumors grew at a pace on par with those that were exposed to higher temperatures. Similarly, feeding tumor-bearing mice with a high sugar drink also obliterated the effect of cold temperatures and restored tumor growth."
That is, cold exposure inhibits cancer growth by activating Uncoupling Protein 1 (UCP1). Therefore, compounds that activate UCP1 can also mimic the effect of cold rooms.
Dinitrophenol (DNP) is the most potent UCP1 activator that has never been approved by the FDA, But in the following article, compounds with UCP1 activating effect were identified in the screening.
Brings to my very simplistic mind -- "Slower Than Molasses In January"
Gee, isn't cold vitally important to >>>
James Webb Space Telescope's MIRI instrument has attained minus 266 degrees Celsius, just a little more than absolute zero (kelvin) or −273.15 °C. The James Webb Space Telescope has reached its operational temperature, which is just a little more than what matter can possibly reach.Apr 18, 2022
Mount Everest (cryo) for my GL10 prostate made sense to me, but then again simple mind
When exposed to cold, the body maintains internal organ temperatures by directing blood flow from the extremities to the internal organs. Frostbite! Prioritizing what needs protection. What can be sacrificed and allow the organism to survive.
Calorie restriction—studies that are decades old have found that calorie restriction increases longevity. The cold temperature requires calories to be burned as fuel to maintain temperature. That is likely the body’s priority.
A link--copy all between the lines to place in your search bar.
The intro to the article--note the date. It is last year, not the last decade:
"Chronic caloric restriction (CR) has powerful anticarcinogenic actions in both preclinical and clinical studies but may be difficult to sustain. As an alternative to CR, there has been growing interest in intermittent fasting (IF) in both the scientific and lay community as a result of promising study results, mainly in experimental animal models. According to a survey by the …
Author: Katherine K. Clifton, Cynthia X. Ma, Luigi Fontana, Luigi Fontana, Luigi Fontana, Lindsay L. Peterso...
Publish Year: 2021"
Is it easy to see an association here? It seems as if the body will prioritize where the fuel is needed the most.
As Captain_Dave is reminded, so am I, of Wim Hof. He was studied at Wayne State University and by others,pubmed.ncbi.nlm.nih.gov/294..., he is able to maintain skin and core temperature avoiding frostbite in very cold temperatures. There have been studies using his technique which combines a specific way of breathing with cold exposure. Here's one published in 2022, pubmed.ncbi.nlm.nih.gov/352... where they explore effect on inflammatory response and cytokine levels.
Interesting that one study of Wim and his brother did not find changes to brown fat metabolism, though they looked for it and they did also consider UCP1, pubmed.ncbi.nlm.nih.gov/250...
Testing on mice is a long way from human trials. I don't know what the parameters were for this "study" but length of time in these environments, where the temperature cut off is and then translating that to human subjects in a broad enough group to study with strict protocols will take a lot of time. I would also be interested to know what are the side effects of being in a cold environment for long periods of time.
You make no mention of advanced prostate cancer in your posting. It would be helpful to know how this treatment directly affects people on this forum. I hope something positive comes from it but right now, I see very little that will impact advanced PCa patients.
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Of Mice And Men...
