I’ve been in treatment since 2013 starting with Proton Radiation. Relapsed in 2016. Began various clinical trials. The last thing that worked for some time was the combination of Abiriterone and Apalutimide and Prednisone. Kept my PSA low and cancer at bay for about 18 months before the cancer started to show up in lymph nodes. Tried 5 cycles of Taxotere; no success. Tried Jevtana including one cycle with Carboplatin. While my PSA is dropping, my lymph nodes are continuing to increase in size and now I also have a bone met on one of my ribs. My Onc (MD Anderson) believes that the progression is indicative of my cancer being small cell carcinoma and perhaps adinacarcinoma My next chemo will be a mix of Carboplatin and Etoposide. He is not being very positive at this point. I recognize this is a very rare cancer, but looking to see if anyone else has had treatment for it. Thanks.
Anyone dealing with Small Cell Carcin... - Advanced Prostate...
My cancer is also small cell. I also did Proton, casodex, zytiga, etc. I have chosen to not do Chemo so I was in the Lu 177 phase II trial, it has worked very well for me. My 4th and final treatment was November 29, 2018. My PSA dropped from 87 to 1.2 as of today it is 2.6. Scans show bone lesions that have generated new bone. I am now looking for a location that I can receive another treatment of the Lu 177.
Scarlino, I have same question as you do, I was diagnosed with Advanced PC with mets in my bones and lungs a year ago, it was remission of mets and PSA undetectable. last week a new CT scan showed me a large mass in my pelvis, was told that it is SCPC mutated from original PC, I wonder if someone in the site experienced can give some advice.
Hi Dasyluo, sounds similar to my story. Originally diagnosed in Oct 2018, achieved undetectable PSA, then ended up in the ER in Januray 2020 with a tumor in my bladder blocking my kidney, later diagnosed as neuroendocrine prostate cancer (another name for "small cell" I believe). PSA still undetectable.
My treatment is Carboplatin + Etoposide + Atezolizumab, in addition to what I was already on. All neuroendocrine cancers are basically the same regardless of where they originated, and this treatment was approved last year for small cell (ie, neuroendocrine) lung cancer. So far it's working very well. If time is of the essence, this seems to be a pretty standard treatment in 2020 that you should be able to start right away. I've never had the luxury of looking for second opinions, my cancer evades tests until I have debilitating symptoms.