Anyone dealing with Small Cell Carcin... - Advanced Prostate...

Advanced Prostate Cancer
10,293 members12,184 posts

Anyone dealing with Small Cell Carcinoma as their prostate cancer?

scarlino
scarlino

I’ve been in treatment since 2013 starting with Proton Radiation. Relapsed in 2016. Began various clinical trials. The last thing that worked for some time was the combination of Abiriterone and Apalutimide and Prednisone. Kept my PSA low and cancer at bay for about 18 months before the cancer started to show up in lymph nodes. Tried 5 cycles of Taxotere; no success. Tried Jevtana including one cycle with Carboplatin. While my PSA is dropping, my lymph nodes are continuing to increase in size and now I also have a bone met on one of my ribs. My Onc (MD Anderson) believes that the progression is indicative of my cancer being small cell carcinoma and perhaps adinacarcinoma My next chemo will be a mix of Carboplatin and Etoposide. He is not being very positive at this point. I recognize this is a very rare cancer, but looking to see if anyone else has had treatment for it. Thanks.

20 Replies
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Here are some clinical trials that you may wish to discuss with him:

pcnrv.blogspot.com/2016/12/...

scarlino
scarlino
in reply to Tall_Allen

Thanks much. I saw those and will let him know.

Yes, definitely. See my profile. I was told to get my affairs together 21 months ago when the Small Cell showed up.

See my profile. Carboplatin and etoposide stopped further tumor growth.

I am in Hawaii for the second time since stopping chemo.

scarlino
scarlino
in reply to DenDoc

Thank you. That is encouraging.

My cancer is also small cell. I also did Proton, casodex, zytiga, etc. I have chosen to not do Chemo so I was in the Lu 177 phase II trial, it has worked very well for me. My 4th and final treatment was November 29, 2018. My PSA dropped from 87 to 1.2 as of today it is 2.6. Scans show bone lesions that have generated new bone. I am now looking for a location that I can receive another treatment of the Lu 177.

mklc
mklc
in reply to Tbrum

So glad the Lu 177 is working so well for you.

If you don't mind me asking where did you do the treatment?

Thank you and good health to you. Mike

Tbrum
Tbrum
in reply to mklc

Excel Diagnostics in Houston. Just wish I could have had 2 more.

scarlino
scarlino
in reply to Tbrum

I definitely have considered it but I do not know if I am PSMA+. Tried to get in study but they stopped taking candidates.

Tbrum
Tbrum
in reply to scarlino

You can still get the Gallium 68 scan at Excel diagnostics. The cost is approx. 4800.00.

scarlino
scarlino
in reply to Tbrum

I will try to get my doctor to do it at MDA.

Tbrum
Tbrum
in reply to scarlino

Good luck hope it works out for you!

scarlino
scarlino
in reply to Tbrum

Thanks. Would like to get insurance to cover it if possible. I appreciate your information. Be blessed!

Tbrum
Tbrum
in reply to scarlino

We are praying that it will get FDA approved for prostate cancer sooner than later.

Scarlino, I have same question as you do, I was diagnosed with Advanced PC with mets in my bones and lungs a year ago, it was remission of mets and PSA undetectable. last week a new CT scan showed me a large mass in my pelvis, was told that it is SCPC mutated from original PC, I wonder if someone in the site experienced can give some advice.

tom67inMA
tom67inMA
in reply to dasyluo

Hi Dasyluo, sounds similar to my story. Originally diagnosed in Oct 2018, achieved undetectable PSA, then ended up in the ER in Januray 2020 with a tumor in my bladder blocking my kidney, later diagnosed as neuroendocrine prostate cancer (another name for "small cell" I believe). PSA still undetectable.

My treatment is Carboplatin + Etoposide + Atezolizumab, in addition to what I was already on. All neuroendocrine cancers are basically the same regardless of where they originated, and this treatment was approved last year for small cell (ie, neuroendocrine) lung cancer. So far it's working very well. If time is of the essence, this seems to be a pretty standard treatment in 2020 that you should be able to start right away. I've never had the luxury of looking for second opinions, my cancer evades tests until I have debilitating symptoms.

dasyluo
dasyluo
in reply to tom67inMA

Hi Tom67in MA,

thanks for your reply, how do you do with the Chemo

dasyluo
dasyluo
in reply to dasyluo

are you still on other drugs such as Zytiga and Lupron? are you expecting to add immunotherapy to the Chemo down the road?

tom67inMA
tom67inMA
in reply to dasyluo

Atezolizumab is immunotherapy, and can be thought of as a competitor to Keytruda (they're both PD-L1 antibodies). I'll remain on that indefinitely after finishing up the carboplatin and etoposide. I'm also Abiraterone (generic Zytiga) and Lupron and Xgeva. It's quite the chemical cocktail!

Are they adding immunotherapy to the carboplatin and etoposide?

scarlino
scarlino
in reply to Rooked

We’re looking into it but I needed a biopsy and those are not being done now so I lost my spot on the immunotherapy clinical trial.

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