Doctors Who Are willing to Supervise Bipolar Androgen Therapy (BAT)

[cesanon]

I believe that Sartor at Tulane and Denmeade at Johns Hopkins in Baltimore. Certainly anyone you want to supervise your Bipolar Androgen Therapy (BAT) , you want to have some experience with it.

I went to Tall_Allen's blog and looked up the BAT investigators on the BAT studies that Tall_Allen cites. Below are what I found. I notice that Dr. Drake is on the list.

Is anyone aware of which of these Docs are willing to supervise Bipolar Androgen Therapy (BAT) outside of those trials? If any of you are already using them as Docs, it should be relatively easy to ask.

Let's work together to put together a list.

Phase 1 Trial of High-Dose Exogenous Testosterone in Patients with Castration-Resistant Metastatic Prostate Cancer

ncbi.nlm.nih.gov/pmc/articl...

Michael J. Morris,a,b,* Daisy Huang,b William K. Kelly,a,b Susan F. Slovin,a,b Ryan D. Stephenson,aCaitlin Eicher,a Anthony Delacruz,a Tracy Curley,a Lawrence Schwartz,c and Howard I. Schera,b

Effect of bipolar androgen therapy for asymptomatic men with castration-resistant prostate cancer: Results from a pilot clinical study

ncbi.nlm.nih.gov/pmc/articl...

Michael T. Schweizer,*† Emmanuel S. Antonarakis, Hao Wang, A. Seun Ajiboye, Avery Spitz, Haiyi Cao, Jun Luo, Michael C. Haffner, Srinivasan Yegnasubramanian, Michael A. Carducci, Mario A. Eisenberger, John T. Isaacs, and Samuel R. Denmeade†

Bipolar androgen therapy in men with metastatic castration-resistant prostate cancer after progression on enzalutamide: an open-label, phase 2, multicohort study

thelancet.com/journals/lano...

Benjamin A Teply, MD

Hao Wang, PhD

Brandon Luber, MS

Rana Sullivan, RN

Irina Rifkind, RN

Ashley Bruns, RN

Avery Spitz, RN

Morgan DeCarli, BS

Victoria Sinibaldi, CRNP

Caroline F Pratz, CRNP

Changxue Lu, PhD

John L Silberstein, MHS

Jun Luo, PhD

Michael T Schweizer, MD

Prof Charles G Drake, MD

Prof Michael A Carducci, MD

Channing J Paller, MD

Emmanuel S Antonarakis, MD

Prof Mario A Eisenberger, MD

Prof Samuel R Denmeade, MD

[Fairwind]

The trouble with these studies and trials, they are usually conducted at just a handful of locations, if that.. That means if you want to participate, you must travel and jump through the hoops on the other end..

This is a VERY simple treatment using a proven safe (more or less) compound that has been around for 60 years or more.. It should be a simple matter to get this treatment but it's not..The only logical reason ? There is no money in it...

[cesanon in reply to Fairwind]

Most docs are scared to do bat.

So we need to compile a list of docs with:

(A) Experience doing it in the few trials, and

(B) willingness to supervise BAT treatment outside of a trial.

Screw the trials.

No treatment is a "VERY simple treatment". This treatment especially. It has lots of nuance and embedded decisions and non-decisions.

Anyone trying this on themselves is engaged in very very self destructive and risky behavior.

[kaptank in reply to cesanon]

I did a risk analaysis and on that basis did DYO Bat and am currently trying to find just how repeatable it is as a management tool (current status ambiguous, will report in a few months). (my onco is cross) Demeade has since confirmed with the Johns Hopkins experience that by and large, with the patients they were selecting the worst outcome was PSA continuing its climb at about the same rate - no worse off than you were - go to the next SOC. There are two effects happening: first the direct response to hi T and second, the resensitization of the previously failed antiandrogen after BAT. (or as in Patrick's case, prevention of resistance in the first place). It was surprisingly easy, could be done by a general practitioner, or by yourself with a little training. Here in Australia where the "T is cancer fuel" myth lives on, there are no doctors willing to prescribe it, particularly to prostate cancer patients. There is however a thriving underground industry supplying steroids to body builders etc. I started out this experiment with great trepidation but at the conclusion I am fairly relaxed about the occassional spike of hi T for a week or so and despite being needle phobic the intramuscular injection is easy to do (but do learn how). Obviously, individual reactions to T vary enormously and one should monitor T and free T and estradiol at the start. Similarly, I take no PSA in the first month but monthly thereafter. You should know within three months of starting whether it works.

A point about risk analysis: having prostate cancer is very risky behaviour and so are all the other things we do to manage it.

Its a very good idea to compile a list of doctors willing to do BAT or prescribe T cypionate with some indication of their experience in it.

I think BAT has potential to become a generally useful management tool to avoid/overcome treatment resistance but we need to know more about sequencing, dosage and overall experience with it. Which is why HU is invaluable. Its not a trial but we can share experience and build up a knowledge base.

[EdBar]

I’m a patient of Sartor and he mentioned BAT to me only as a way to rechallenge Xtandi when it fails - it would be an option for me. The other was to rechallenge with Jevtana. He has had some success with both.

Ed

[Alvin735 in reply to EdBar]

I'm a patient of Dr. Sartor's as well. He had me doing BAT for about 6 weeks, but PSA kept rising and had a tumor on my spine (C6) that was growing, so went onto chemo instead of continuing BAT. (had already radiated my spine as much as it could take back in 2012)

[Sapmiami]

Any updates to locations? My friends dad is going tk Johns Hopkins and doing fantastic on BAT. Anyone know of a place in Florida? Thanks if you do know!!