With so many bonafide experts on this forum, is there a consensus yet on the cause of prostate cancer? And how those could seek to prevent it?
I've known Prof. Edward Friedman for many years and used to speak to him often. His book is also excellent.
I am also convinced that Estradiol is the culprit. I remember Ed telling me that if no prostate cancer cells were present then it was impossible for Prostate Cancer to occur in the presence of aromatase inhibitors.
If testosterone was the culprit it would be a young mans disease, and Arnold Schwarzenegger and Sly Stallone would have died from it years ago!
I am 38 years old, and my Father has had prostate cancer now for over 20 years, so it is something personally I need to be on top of, and I am sure there are many men on this forum would also want there sons / nephews etc to be privy too also.
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taylor123
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Taylor, this is the mother of all questions...why do we have prostate cancer.????..to my knowledge, the cause is still unknown. My Urologist, who has prostate cancer told me that only 12 % of all pCAs are genetic.
In my own case, there no family history...there is nothing to explain why I got pCA ? I was very healthy...and my first ever hospital admission was at age 61 with UTI leading to diagnosis of pCA. Puzzling to say the least.
BTW - cancer rates are growing because detection methods have improved, This is a good thing. Deaths from many cancers have been decreasing with earlier detection.
My MO thinks getting old is a major factor because body's ability to regulate proper cell division and keep normal cell architecture becomes impaired with age. .But that does not
explain why younger people get cancer.
Demographically, prostate cancer rates are highest in USA and UK and lowest in China and India ...Latin American rates are in intermediate range.(source:oncology textbook)
We all want to be able to explain why, because then we feel like we have control.
My husband has a family history of aggressive prostate cancer, but no known genetic mutations.
He is tall (I read this is a risk factor —lol—) and his diet is a 10/10 and has been for most of his life.
He doesn’t smoke. He is free of all alcohol, for entire adult life.
Who knows what causes it. I think if it’s gonna happen, it’s gonna happen, so please pay attention if you have a family history. Good luck to you in your journey. We are here to learn from this adversity.
If anything his was high. He never had any indication of low T. Always maintained muscle mass without lifting weights. Even with Time. Aged very gracefully and looks many years younger than his numeric age. No symptoms of low t ever. But his father died from PC, so I think for us, there was an inherited vulnerability.
Some Testosterone will aromatase into estradiol also. Professor Friedman at around 75 years of age keeps his T levels at 1500 and E2 low with low doses of a daily aromatase inhibitor. His PSA has never been above 5.
His book explaining these mechanisms is brilliant and I know Dr Bob Leibowitz holds his work in very high regard also.
Hello, What is the name of Professor Friedman's book. Also has Dr. Bob commented on doing very high dose T to kill the cancer? An oncologist suggests this if all else has failed . Any research or knowledge on this will help. Thanks
My brother wierdly adores large wire haired dachshunds....
they defy all attempts of gentrification.....Im left to walk them when visiting where they transform to what I consider normal behavior....anyway I suppose outward appearances do make a good case for high T genotypes. As I say its something l read but piqued my interest as mine ostensibly is /was low. My mad theorizing has inductively concluded that we low T variants are highly endowed with voracious androgen receptors(ARs) ....which may explain my highly responsive response to ADT...of course the flip side to my theory is highly expressive ARs is the high risk by shear number of implied mutagensis....never a good thing.
Nice answer. From a high level view of population growth and the increasing toxicity of the environment, it sure makes logical sense that nature would find away to cull.
My opinion is Darwinian Evolution at work. DNA constantly changes through division errors or external influence. Some of those changes make us taller, faster, stronger. Others make cells cancerous. This process happens in all life on Earth, it’s the price we pay for being adaptable and able to evolve.
I think the cancers in younger people are probably provoked by environmental contaminants. I know researchers are busily seeking correlations to explore.
What interests me more is how involved humans are with blaming others for their health. There is a pervasive underlying subconscious thing going on where we blame people for their cancer. The first question when someone announces lung cancer is often "did you smoke?" People have asked me outright if my husband went to the doctor regularly, and why he didn't have a PSA test, even though it's no longer recommended for general screening.
Why are we so arrogant and superstitious as a species that we believe diet or exercise or religion or the right thinking can prevent cancer? (General question, OP, not targeted at you.) Always makes me think of Groundhog Day where the nurse tell Bill Murray "sometimes people die" and he responds "not today."
I have cats that have an uncontrollable urge to overpopulate. They are very noisy and invite all the neighborhood cats to their orgies. I have learnt that air soft guns, and paint ball guns are considered animal cruelty, so, off to Wal-Mart to buy the biggest machine squirt gun they have. How do you like smelling like vinegar cat?
Just my opinion, ductal cafcinomas are caused after cronic inflamation due to low oxigen, low blood flow, low vitamin D and zinc and some other stuff, ... that leads to proliferation of some fungi in the narrowest regions of glands (pancreas, breast, bile, prostate). The fungi is the cause of the inflammation and the inflammation causes fast proliferation and more % and fast abnormal cells arise, and at some point your immune system is weak and the bad cells overflow, and then mutate
There are undoubted genetic factors, these can be seen in the fact that if you have male relatives with prostate cancer your risk is enhanced and it is more likely in some populations than others.
There are also environmental / lifestyle factors as well, this can be seen from the fact that men from the same racial background have different rates depending on where they live.
The annoying thing with the latter is that despite a lot of looking we have not found any really clear links eg reduce drinking / take more vitamin x and reduce your chance by 50%.
When doctors showed the link between smoking and lung cancer there was a lot of hope that there were similar links for other cancers but this has not turned out to be the case.
Aging is also an important factor, as men live longer more of them will develop prostate problems including prostate cancer that may be more or less benign. It is a fact that men in their eighties will almost all have prostate abnormalities.
Aging contributes to the blind chance factor of random mutations, transcription errors in the DNA of prostate cells and this seems to be the most important one with the longer you live the more chance you have of getting it.
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