Not gaining weight on Lupron - Advanced Prostate...

Advanced Prostate Cancer

21,011 members26,186 posts

Not gaining weight on Lupron

dac500 profile image
18 Replies

So far I have been on Lupron for a total of fifteen months. In 2017, I had Lurpron for six months when I had cyberknife for recurrent prostate cancer. That time I had some weight gain, between five and ten pounds. Currently, I am on Lupron plus Casodex since November 2018 for metastatic prostate cancer in pelvic and abdominal lymph nodes. This time I have not gained any weight. As a matter of fact I have lost a few pounds. My current weight is a pound or so lower than my weight before starting Lupron in 2017. I would be interested to know about men not gaining weight on Lupron.

Written by
dac500 profile image
dac500
To view profiles and participate in discussions please or .
Read more about...
18 Replies
JamesAtlanta profile image
JamesAtlanta

I have lost 15lbs since I started ADT. I watch my calories and exercise daily. (My MO had told me to expect to gain 20lbs.)

I’m 185lbs today and weigh only 5 lbs more than when my wife and I got married 33-years ago. My goal is to get down to 180 this summer.

Thanks for asking!

James

Schwah profile image
Schwah

I lost weight too. But I did hard weight training 3 days a week and watched what I ate. Fear is a good motivator. I’ve also read that metformin tends to help you lose weight

Schwah

timotur profile image
timotur

I noticed the tendency to gain belly fat on Lupron/Zytiga but have kept it in check through exercise, diet, and intermediate-fasting. Started HT about 4 months ago, and weight went from 148 to 143lbs, probably due to lost muscle-mass.

whatsinaname profile image
whatsinaname

I have taken Eligard 45 mg (a six monthly injection). Its supposed to be very similar to Lupron. I have been on Eligard since the beginning of March, 2018, about 17 months now.

I was about 175 lbs till the end of February, 2019. Since then I have lost weight and am now about 160 lbs. This is without any exercise at all. On the contrary, I have cut down on the small amount of walking I used to do. Instead, I read a bit more :-)

tom67inMA profile image
tom67inMA

I've lost 10 or more pounds since diagnosis while on Eligard/Lupron, but mostly due to radiation and chemotherapy messing up my digestive system. I was just starting to show signs of regaining when I started Zytiga + Prednisone, and now I'm eating a bit extra some days to prevent further loss. Even with the weight loss I still have some belly fat but my arms and legs are scrawnier than they have been in years.

While extreme or ongoing weight loss is bad, I'm convinced moderate weight loss followed by stabilizing at a lower but still healthy weight is a good thing in the battle against cancer.

dac500 profile image
dac500

My PSA dropped from 4.48 in November just before starting Lupron to 0.1 by end of May. Isn't that an indication that my Testosterone is down to castrate level?

LearnAll profile image
LearnAll

I am on Lupron for a month....have lost 2 lbs. Eating only plant based diet. walking 4 miles a day, Hope weight loss does not become a trend. Currently I am at my ideal weight.

jdm3 profile image
jdm3

My weight stayed just about the same. I eat well and exercise a lot… But I still lost muscle mass and gained belly fat and a thin, but noticeable layer all over my body.☹️

Longterm101 profile image
Longterm101

Why E2? Stay healthy

joeguy profile image
joeguy

I have been on Eligard (Lupron) or Firmagon for 2.5 years, and I have gained about 20 pounds. Weight was always very steady before ADT

Longterm101 profile image
Longterm101

Thx mate!!

Gearhead profile image
Gearhead

Lupron/Zytiga for 6 months. No significant weight gain or loss. I'm skinny (162 Lb, 6'1'') and weight hasn't changed +/- 5 lb in 30 years. Seems like a bit more belly flab, but doesn't that come with being 76? I tell myself that, except for having Stage IV PCa, I've got a lot to be thankful for at my age. I even have a full head of hair.

JavaMan profile image
JavaMan

I was told the average was 9lbs weight gain when going on Lupron. I am in my 5th of a 6-month course and have lost about 5lbs. I did not want the weight gain either so started to pay attention and eat only when I was hungry and slow down how quickly I ate. I have also been cycling a lot but I feel my strength weakened from pre-Lupron days.

pakb profile image
pakb

My husband's weight has stayed steady in almost 2 yrs on lupron. He did switch to a completely vegan diet and he works out. Weight was always steady before diagnosis- he was a college athlete and stayed active.

westof profile image
westof

So far I’ve had ADT (Casodex with Lupron(9/1/18) and now Lupron with Zytiga(4/1/19), with a side of predisone). Brachytherapy (April 26th) and have completed 25 days (of 25) of RT on 7/8. Bottom line, no side effects and I feel great.

I lost 2 lbs in the past 3 weeks and I'm not overly concerned. Never gained any weight.

roslynlady profile image
roslynlady

My husband is on 4 month Lupron shots. He had his first in January and his second in May. He also is on 48 radiation treatments and has not gained any weight. His most difficult side effects are muscle weakness (muscle wasting as it's been called) particularly in his core and legs and constant night urination and possibly some "brain fog."

dac500 profile image
dac500 in reply to roslynlady

Muscle weakness, fatigue, and depression are the common side effects of Lupron. Since your husband is undergoing radiation treatment, the Lupron shots may end after the radiation treatment is complete. In my case, the cancer in the prostate was killed by brachytherapy in 2011. I had to undergo my second radiation treatment for recurrent cancer outside the prostate. Since April 2018, my cancer has spread to many lymph nodes. I may have to be on Lupron on a long term basis.

j-o-h-n profile image
j-o-h-n

I don't know which is bigger, my belly or my tits?

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 07/17/2019 8:01 PM DST

You may also like...

Lupron shots and weight gain

I heard Lupron will give you weight gain and wondering ,if i take a protein drink and eat a lot of...

Frustrated with Lupron weight gain and not being able to drop #'s

Prednisone since Sept 2019. And Lupron injection again. Disappointed with: Weight gain and lack of...

Gaining weight on ADT

few bone and lymph node mets. PSA levels have dropped to no-detect for the past 6 months. Wooooot!...

Gaining weight, muscle aches

biopsy and had a Gleason 8, removed prostrate and 5 lympnoids on October 4th, started lupron...

weight gain, ADT and diet

since ADT causes weight gain (and it isn't muscle).\\" In my case, following Lupron for 2 years and...