How low can you go?

[CantChoose]

Hubby had his first chemo today. He was diagnosed around 4/1 with PSA at 285 and AP at 1600. First Firmagon around 5/8. Today, PSA was 3.6 and AP was 301.

Is it true that the lower you get, the longer you live? What's the expectation for PSA decrease? Obviously it's good that it's decreasing but is the likelihood/expectation that he can get to undetectable?

[6357axbz]

This article shows correlation between Testosterone nadir and occurrence of HRPCa

ncbi.nlm.nih.gov/pmc/articl...

There are some studies indicating the lower your PSA and the longer it takes to get there the better of you are. Unfortunately I don’t have any of those at my fingertips. Perhaps someone else here has them handy.

[dockam in reply to 6357axbz]

"In this study, we have demonstrated that the cutoff value of TTN following PADT for predicting progression is inversely correlated with disease progression in PC patients. The optimal cutoff value of TTN for predicting low risk of progression might be TTN >8 months in advanced PC patients with BM and TTN >11 months in those without BM regardless of nadir PSA levels."BM - bone mets

From this: erc.bioscientifica.com/view...

Fight on

[Tall_Allen]

Congratulations on the excellent response.

[CantChoose in reply to Tall_Allen]

Thanks, TA! We're certainly happy things are going in the right direction.

[tango65]

Excellent response. Let'us hope the PSA will continue going down. Congratulations!! Best of luck.

[MarkBC]

I was diagnosed a year ago. ADT plus chemo brought my PSA down quickly from 103 to around 2. I have my PSA tested monthly. There was a slow decline afterward. I thought I hit my nadir at just under 0.3 for about three months in a row. My last two tests show further declines to 0.21 and now 0.17. I'm hoping this trend continues. Let's hope your husband's PSA keeps declining too.

[CantChoose in reply to MarkBC]

Thanks, super helpful. Sounds like this is right in line with expectations then. We'll hope it keeps going down. 😊

[j-o-h-n]

UP bad, Down Good. Congrats!

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 06/28/2019 9:20 AM DST