Phase 2 Clinical Study of 1095 Radio... - Advanced Prostate...

Advanced Prostate Cancer

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Phase 2 Clinical Study of 1095 Radiotherapy for the Treatment of Metastatic Prostate Cancer

George71 profile image
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" Progenics' small molecule therapeutic candidate 1095 is designed to bind with high affinity to the extracellular domain of prostate specific membrane antigen (PSMA), a protein that is highly expressed in prostate cancer cells. Once bound, 1095 is internalized by the prostate cancer cells, where the beta radiation emitted by iodine-131 kills the malignant cell. This ability to deliver targeted radiation systemically to PSMA expressing cancer cells represents a novel therapeutic mechanism of action to treat prostate cancer. When studied in a compassionate use setting, 1095 markedly reduced PSA and bone pain in a group of heavily pre-treated advanced prostate cancer patients.”

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George71 profile image
George71
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Fairwind profile image
Fairwind

Sounds like the race is on to get FDA approval for one of these very similar treatments.. The phase 3 "Vision" trial which is testing Lu-177 / PSMA 617 works the same way and is having encouraging results..

tango65 profile image
tango65

Thanks for posting.

NPfisherman profile image
NPfisherman

Thanks for posting, George....

Fish

BruceSF profile image
BruceSF

Quick note: this study is targeted to men who don't want to do chemo (yet) and would prefer to try a lutetium-like treatment first. Also, they are expanding sites all the time, and will be in the sf bay area in a few months at Stanford and the Palo Alto VA. Watch for updates at clinicaltrials.gov/ct2/show...

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