Statins reduce risk of developing PCa, as well as dying from it

[curious-mind1]

Yet another report on the beneficial use of statins in relation to PCa:

1. health.harvard.edu/blog/lon...

2. ncbi.nlm.nih.gov/pubmed/303...

Arthur

[Budvar]

I've read a few news articles on this report but none of them mention dosage? My dad is only on 40mg of Avorstatin. Anyone know if that would be sufficient and if Avorstatin is a good one to take? Also the second study you linked mentions aspirin. My dad used to take low dose aspirin occasionally but as far as I know he stopped. I wonder if it would have immediate impact or if its something you really have to take 10+ years to notice a difference at all? Any of you take low dose of aspirin?

[curious-mind1 in reply to Budvar]

My dad takes simvastatin, forget the dose, but I think it's pretty standard (as in his cardiologist would approve of the dose). Dad's oncologist stated that the effects of the statin accumulate over time, so it is not something that would be make a difference immediately, but over time.

[Garbonzeaux in reply to Budvar]

Bud,

I have been taking a baby aspirin and Crestor every day for many years, but not sure it helps the PCa, which I am fairly new to (18 mo). The Crestor is a low dose, 10mg, and I am thinking of asking my cardiologist to up that.

[CalBear74 in reply to Garbonzeaux]

Garbonzeaux,

As I understand it, Rosuvastatin (Crestor) is relatively hydrophilic. You want to be taking a lipophilic statin like simsvastatin, atorvastatin, or lovastatin. I am not a physician or a pharmacist so I would suggest talking to an oncologist about the desirable statins to take in fighting Pca. This area is being actively investigated at this time so things may have changed.

[Garbonzeaux in reply to CalBear74]

Good idea, Cal. Scheduled to meet with MO tomorrow. I'll bring it up.

[PhilipSZacarias in reply to CalBear74]

I talked to my MO about switching from Crestor to a lipophilic statin (based on literature for other types of cancer), and he said that I should definitely stay on Crestor because of recent research - we did not have enough time to get into the details unfortunately. Crestor (rosuvastatin) is one of the more effective statins for lowering cholesterol - so it is more efficacious on an equivalent dosage. A 10 mg dosage of Crestor is equivalent to 20 mg of simvastatin for example. Phil

[CalBear74 in reply to PhilipSZacarias]

Your doctor's choice seems sound if you are focusing on cardiovascular health factors.

[PhilipSZacarias in reply to CalBear74]

I agree, since my LDL-C is elevated (due to ADT), but his recommendation was in the context of PCa - I did not mention that my LDL-C was high during our meeting. Phil

[GeorgeGlass in reply to CalBear74]

Snuffy Myers was saying Livalo might be a good option. Have you heard of that one?

By the way, how much of that IP-6 do you take, which brand, and do you take it with alkaline water? I read an study that showed IP-6 with PH-12 is most effective.

George

[CalBear74 in reply to GeorgeGlass]

I take 7 scoops mixed in ordinary filtered water on an empty stomach (2 hours) and 7 scoops of the same powder (Enzymatic Therapy's Cell Forte) in the late afternoon. Please provide a link to the study you cite on PH-12.

[GeorgeGlass in reply to CalBear74]

I'm looking. Sometimes I find an article and then can't find it again. In the meantime, I found this: ncbi.nlm.nih.gov/pmc/articl...

In the study charts you'll see that 400 and 800 (international units?) induce the highest apostisis. Do your 14 scoops equate roughly to 400-800?

[CalBear74 in reply to GeorgeGlass]

Far exceeds that amount (see my note below on equivalencies). You will find on the label of a Cell Forte canister the grams of powder in a scoop they provide and the rest is simple math. Keep in mind that IP-6 is a dose dependent medication in its action on cancer cells. Dr. Shamsuddin in his review of IP-6 cancer studies emphasizes this.

"1 IU is the biological equivalent of 0.025 mcg cholecalciferol or ergocalciferol. Vitamin E: 1 IU is the biological equivalent of 0.67 mg d-alpha-tocopherol, or 0.9 mg of dl-alpha-tocopherol."

[GeorgeGlass in reply to CalBear74]

I read so many studies i can remember... Have any studies show that taking the amount you are taking orally resulted in shower cancer progression than not taking it, or are you hypothicizing/extrapolating? Just curious because it takes pretty strong dedication to take 14 scoops a day.

Have you had side effects from it?

Thanks,

George

[CalBear74 in reply to GeorgeGlass]

George,

Please read Dr. Shamsuddin's book which offers extensive reviews of research findings on IP-6. The findings repeatedly point to dose dependency in results. My own experience indicates 12 scoops daily of IP-6 powder gets results measured by PSA levels; however, I have come to believe given what other men have told me that good results - clear suppression - can be achieved with lower doses. I think the big challenge for IP-6 users is finding the dose that their body requires to be effective. Our cancer cells differ - which is why we have Gleason scores. I don't advocate 14 scoops. I think the typical prostate cancer patient should start with 3 scoops in the AM and 3 in the PM. Before starting have a PSA test. After 6-8 weeks have another test. Ratchet up the dose if the results are not satisfying. 50% increase.

amazon.com/IP6-Inositol-Nat...

[GeorgeGlass in reply to CalBear74]

OK good info. Thanks Cal!

George

[GeorgeGlass in reply to CalBear74]

Here it is: IP6 with PH12 shows best results: ncbi.nlm.nih.gov/pmc/articl...

[j-o-h-n]

I take one Simvastatin 10mg tablet every night before going to bed. So far I'm still dying...

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 01/09/2019 2:01 PM EST

[Drphil1938 in reply to j-o-h-n]

I have been taking 40 of Lipitor with a baby aspirin for over 30 years. Gleason 9 came along anyway but " I woke not dead again this morning." I love Willie Nelson.

[j-o-h-n in reply to Drphil1938]

What a coincidence Willie is my house guest this week.... He said this is just for you...

youtube.com/watch?v=J34esa_...(Not working as expected?)

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 06/26/2019 11:05 PM DST

[Drphil1938 in reply to j-o-h-n]

Stay out of Willie's stash this week. If your post are a little fuzzy we all will know why.🤪

[j-o-h-n in reply to Drphil1938]

I never knew that paint chips in the corner of my windows could be sooooo beautiful........they're sooooo fuzzy too.......

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 06/27/2019 4:47 PM DST

[Drphil1938 in reply to j-o-h-n]

🤣🤣😂

[Drphil1938 in reply to j-o-h-n]

Isn t that a great song. I nominate it for this site's theme song.

[j-o-h-n in reply to Drphil1938]

great by my choice would be:

youtube.com/watch?v=-5PDy1T...(Not working as expected?)

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 06/28/2019 1:44 PM DST

[Drphil1938 in reply to j-o-h-n]

Our taste in music is different but we both like ice cream.🤠

[j-o-h-n in reply to Drphil1938]

GMTA

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 06/28/2019 4:44 PM DST

[Drphil1938 in reply to j-o-h-n]

GMTA. What does that mean? I am from Missouri, you have to show me.

[j-o-h-n in reply to Drphil1938]

The show me state huh.... Great Minds Think Alike

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 06/29/2019 8:41 PM DST

[Drphil1938 in reply to j-o-h-n]

DUH, I must have brain

Fog not to figure that out. 🤪

[j-o-h-n in reply to Drphil1938]

Naw.... my son had to tell me that one..... you still have it.... I know but can't remember where you put it....Ohhhhh If I only had a brain,,,,or could remember where I put it....

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 06/29/2019 9:02 PM DST

[Stegosaurus37]

I take 40 mg of atorvastatin daily. It has had a positive effect on my cholesterol level (which is why my PCP prescribed it), But my prostate cancer, after having defeated all the standard therapies, is still going strong.

I did take a baby aspirin each day a few years ago but gave it up almost immediately as it was giving me uncontrollable nosebleeds.

[CalBear74 in reply to Stegosaurus37]

Are you taking Metformin or its natural bioequivalent Berberine root? Dr. Mark Scholz recommends both in his book "The Key to Prostate Cancer". Excellent read.

[Stegosaurus37 in reply to CalBear74]

Never heard of either. Not that that means much; the world is full of stuff I've never heard of. My cancer is super tough; it takes all the conventional treatments, chews them up and spits them out. So I'm only on lupron now, which isn't doing me a heck of a lot of good. Aside from the cancer I am in excellent health and always have been. The cancer is the only problem I have so I don't worry too much about other therapies.

[PhilipSZacarias]

Please note that the second reference pertains to aspirin

[curious-mind1]

@PhilipSZacarias , thanks for catching this. I have updated the link at the top.