Has anyone had experience with metastatic prostate to bones, bladder and liver. Stage 4 and Gleason score 10. My husband of 36 years was diagnosed about 15 months ago. Started using Lupron, Xgeva, zytiga & Xtandi and tactotere. Nothing has worked and now he has completed 10 rounds of radiation. Also started Jevtana and developed severe diarrhea which required hospitalization. We discovered the progression to liver with multiple lesions. He has lost 10lbs in less than 10 days. PSA remains high at 112, are these symptoms of the body not being able to keep up with cancer? Oncologist has never seen such an aggressive form of cancer that refuses to respond to any treatments. How much time is left?