My Dad died of colon cancer, my Brother of melanoma. With a stage 4/G9 w/bone mets only in '16 and enjoying leuprolide/enzalutamide after docatexel (6 in '16), I'd think Carboplat would be a no-brainer. Avodart, as well. What hoops are there?
Crabcrusher
Carboplatin is toxic and so far has only been useful when there are known DNA repair defects or some rare types of PC (like neuroendocrine). If docetaxel has stopped working, Jevtana might.
Avodart is like a drop in the ocean if you are taking leuprolide/enzalutamide - all it does is add side effects.
Ten four. Sorry you had to answer the Avodart question twice; I was figuring it in for the capability of preventing free T from converting to DHT, as well as gland shrinkage. At 30 months on the lupron, and riding the sipeleucel-t protocol, what do you say about a break for a couple of quarters before the cabazitaxel, and resuming enzalutamide and Lupton at that juncture. I've never doubled to over 4.4 since Dx in '16.
If the Lupron is working, the amount of testosterone is negligible. Any androgen (free T, DHT, etc.) that is there is blocked by the Xtandi - that's why I don't see a role for Avodart.
I think chemo and Provenge go well together.
Hussain's study on intermittent ADT suggests that continuous may be preferable when there is a low metastatic burden.
Okie doke. I got a new lesion last month, and the reason for the province was the rise in PSA. Doubled. I asked him to replace the Casodex with Xtandi, so I don't know where I'm at, to dangle a participle. I assume sympathetically you'd be comfortable with a status quo and wait 'I'm watch on the Provenge with Lupron/Xtandi...
Thanks,
Crabcrusher
Lol provenge and empathetically
You are the one that has to be comfortable - I'm just throwing out info.
The Objective Defense, eh?
I can take anything they dish out; I'm lookin' to maximize potential.
I did docetaxel mixed with Carboplatin and it worked really well! Knocked it right out.
What were the preliminary stipulations, if you don't mind?
Jackie Gleason of 9, widely disseminated multifocal disease with bone mets and lymph involvement.
To clarify, the docetaxel/Carboplatin bought me a Year then upon recurrence went to Jevtana, 6 cycles, then on Xtandi with Lupron. I am now zero PSA
No genomic test?
Praise God-you'll do to take along, bro.
In process of genome test now
Please see my bio for more complete treatment history.
Had 6 cycles of Docetaxel/Carboplatin in 2017 for lymph nodes and liver. Worked and got another 4 months from a rechallenge with Xtandi.
Thursday will have 6th infusion on round 2 with Docetaxel/Carboplatin combo but PSA is rising this time.
Liver MRI tomorrow and then to plan next steps. Since I have ATM defect and have already used Lynparza, a PARP inhibitor, may try Keytruda. Love my open minded and up to date Med Onc!
Best wishes. Never Give In.
Mark, Atlanta
Outstanding!
Have you considered Provenge?
Nous Defions
My Med Onc is not a great believer in Provenge nor am I. Lots of money and trouble for a 4 month extension of life. Thanks.
Mark
Sound reasonable, if that were the case. Unless they come up with the silver bullet at 3.5 months and you had turned it down, lol. I have a different angle on it; study the stats (ages, etc.)
Nous Defions
Crabcrusher
Watch out for the Avadart. It will give you false readings on your PSA.
UK Cabazitaxel/Carboplatin availability
Jevtana and carboplatin
Cabazitaxel plus carboplatin
Taxotere + Carboplatin
