The results obtained can be summarized as follows. Firstly, cannabinoids and BDS reduced PCC viability with higher potency and efficacy in the absence of serum proteins, and regardless of the presence of hormones in the medium and of the androgen dependency of the PCC line under study. With serum deprivation, CBD was the most efficacious compound in three out of the four cell lines investigated. These results are in full agreement with previous observations in glioma cells (Jacobsson et al., 2000). Secondly,amongst all the possible known cannabinoid targets investigated, only TRPM8 channels, when present (as in LNCaP cells), seemed to mediate, and only in part, the effect of CBD. Finally, under certain dosing conditions, CBD produced synergistic effects with docetaxel and/or bicalutamide in DU‐145 and/or LNCaP cells.
Based on this first set of results, we decided to test CBD against the growth of xenograft tumours generated in athymic mice from LNCaP and DU‐145 cells. As CBD–BDS was more efficacious in vitro than CBD in the presence of serum proteins, we administered this preparation. Given alone, CBD–BDS reduced tumour size in xenografts generated from LNCaP cells. In these tumours, CBD also significantly enhanced the anti‐cancer effects of bicalutamide (extending the survival time of the animals), but not those of docetaxel. Instead, CBD–BDS was inactive by itself against the growth of DU‐145 xenografts in vivo, although it potentiated the effect of docetaxel. These findings suggest that Cannabis extracts enriched in CBD might provide the basis for new therapies against prostate carcinoma, either as stand alone treatments or in addition to currently used drugs for this type of tumor.
I tried CBD oil at one point, but I had severe gastric cramping--not sure if I took too much...I do know some here take it sublingual...I may have to try that route...
Unfortunately, the body’s detoxification pathways clear CBD so rapidly that it not possible to achieve a therapeutic concentration in the blood and cancers. Philip
Didn’t all Dr Sanchez's patients with Glioblastoma, which she treated with direct infusion of CBD, die of exactly the same Glioblastoma?
I’m not a big fan of in vitro and mice results being promulgated as proof of efficacy for humans.
FWIW, I take very high doses of CBD in high concentrations, not for the cancer, but to help with side effects of cancer treatments. Seems to help me but no idea if it would help anyone,so I can’t see recommending it to anyone. But if they’ve recommended it to themselves, I recommend using industrial hemp, because it is much cheaper than buying CBD oil or CBD products, like from 1/10th to 1/100th the cost, and also, doing your own whole plant extraction you get entourage effects which you don’t get from isolated CBD extracts. I’m in 7th week of salvage IMRT w/ abiraterone and yesterday I played tennis for 90 min very hard, then went running the did 40 push-ups in 40 seconds and posted a vid of it to Facebook. Not saying it would or even might help anyone else. I only use it in addition to really good medical treatment, alongside it, and I had no real expectations for it. But if one does, I recommend with, not instead of proper medical treatment, whole plant not isolate or extract, cheap homemade vs expensive store boughten, and finally whole plant or whole plant extraction for entourage effects.
Along with THC CBD is one of the big two cannabinoids, but there are many others. If using either in the form of products, e.g. oil, gummies, capsules, whatever, one might not get the full entourage of cannabinoids, including some which might require the presence of others in order to be therapeutic at all. It’s not certain this is so, we simply don’t know yet, but it has a distinct possibility.
Whole plant is when you start with the whole plant, as in making cannabutter, e.g., a simple extraction into a simple fat.
An eagle swoops down from the sky and eats a zonked mouse. Three hours later, while the eagle is flying, the mouse sticks its head out of the eagle's butt and asks, "How high up are we?"
"About 2,000 feet," the eagle replies. The mouse replies, "You ain't sh*ttin' me, are you?"
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