Red Hot Peppers

[George71]

"Capsaicin is the major pungent ingredient in red peppers. Here, we report that it has a profound antiproliferative effect on prostate cancer cells, inducing the apoptosis of both androgen receptor (AR)-positive (LNCaP) and -negative (PC-3, DU-145) prostate cancer cell lines associated with an increase of p53, p21, and Bax. Capsaicin down-regulated the expression of not only prostate-specific antigen (PSA) but also AR. Promoter assays showed that capsaicin inhibited the ability of dihydrotestosterone to activate the PSA promoter/enhancer even in the presence of exogenous AR in LNCaP cells, suggesting that capsaicin inhibited the transcription of PSA not only via down-regulation of expression of AR, but also by a direct inhibitory effect on PSA transcription. Capsaicin inhibited NF-kappa activation by preventing its nuclear migration. In further studies, capsaicin inhibited tumor necrosis factor-alpha-stimulated degradation of IkappaBalpha in PC-3 cells, which was associated with the inhibition of proteasome activity. Taken together, capsaicin inhibits proteasome activity which suppressed the degradation of IkappaBalpha, preventing the activation of NF-kappaB. Capsaicin, when given orally, significantly slowed the growth of PC-3 prostate cancer xenografts as measured by size [75 +/- 35 versus 336 +/- 123 mm(3) (+/-SD); P = 0.017] and weight [203 +/- 41 versus 373 +/- 52 mg (+/-SD); P = 0.0006; capsaicin-treated versus vehicle-treated mice, respectively]. In summary, our data suggests that capsaicin, or a related analogue, may have a role in the management of prostate cancer."

ncbi.nlm.nih.gov/pmc/articl...

youtube.com/watch?v=Yslpwae...(Not working as expected?)

[Hidden]

I've been a red hot peppers and all nuclear hot stuff consumer all my life. For some reason my taste buds needs to be scorch to taste some flavor. But, got PCa, PSA 1000+ at Dx!

The hottest sauce that I've tried that can be purchased in the US is Dave's Insanity Sauce. Just a fingertip drop would have annihilate all prostate cancer cells in a few seconds!

[NPfisherman]

Thanks for posting George71.....

I am a firm believer in diet changes to deal with the beast. This is no surprise to me as I am a firm believer in Curcumin with bioperine, and take cayenne pepper on a daily basis. I drink ginger tea, but going to order the advanced curcuminoids with ginger from Life Extension that Nalakrats takes--extended release . Enjoyed the video with Dr Charles "Snuffy" Myers... endorsed by the legend....

Have a great evening,

Fish

[charlesmeyers1964]

thats great if u and your body can handle red peppers

[BrentW in reply to charlesmeyers1964]

I tried it for a couple of months. The result was weight loss -- due to amazing diarrhea!

[CalBear74 in reply to BrentW]

What was the Scoville Heat Unit rating on the cayenne pills you were taking? Find a pill that is a lower rating and go a few weeks until the supply is gone and move up to a higher rating. Take it with food. I had some cramping when I first started. It went away and now everything is find. The SHU is 90K on my Swanson's Super Cayenne.

[BrentW in reply to CalBear74]

Thanks, but no thanks. That was in about 2008. Since my RP (2010), I have been exquisitely sensitive to hot stuff 'down there'. So, it's not for me.

[pjoshea13]

I use:

swansonvitamins.com/natures...

100,000 heat units (Scoville units).

Oddly, there is no discomfort at any part of the GI tract.

-Patrick

[Hidden]

Thanks George.. How much do you take daily?

[j-o-h-n]

They say "how does a ________(fill in your favorite ethnic group) know he's hungry?

When his asshole stops burning.

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 02/24/2019 11:53 AM EST

[monte1111]

Oh my god. Nalakrats sounds just like he was in an episode of Back to the Future! The references to extreme diarrhea and issues down there and a_ _ holes burning are hilarious. I do admit that since chemo, my use of the hot peppers has declined some. If the use of hot peppers in diet prevented Pca, I should not be where I am now.

[rocket09]

Let's hear it for the peppers. Yeah!!@@