"MTT analysis indicated that clinically relevant concentrations of ibuprofen significantly reduced the survival of LNCaP human prostate tumor cells. TUNEL analysis demonstrated that this was due in part to a significant number of LNCaP cells undergoing apoptosis. Ibuprofen also induced the same amount of apoptosis of an androgen-independent human prostate cancer cell line (DU-145), but had little effect on normal mouse fibroblast (3T3) cells. Cell cycle analysis indicated that ibuprofen caused LNCaP cells to shift from the S and G(2)/M phases to the G(0)/G(1) phases of the cell cycle. Another propionic acid NSAID, naproxen, had an effect similar to but overall less than that of ibuprofen. Suprapharmacological concentrations of aspirin and acetaminophen did not induce levels of apoptosis in LNCaP cells similar to those induced by clinically relevant concentrations of ibuprofen. The selective COX-2 inhibitor NS-398 mirrored the effectiveness of ibuprofen against LNCaP cells in vitro. However, when the pharmacokinetics of selective COX-2 inhibitors and other NSAIDs reported to be effective against prostate cancer were taken into consideration, ibuprofen appeared to be one of the most effective NSAIDs at clinically relevant concentrations. "
Results:Ibuprofen was significantly ... - Advanced Prostate...
Results:Ibuprofen was significantly more effective against human prostate cancer cells in vitro than the other tested nonprescription NSAID
This appears to be an old article that does not seem to have aged well.
pubmed.ncbi.nlm.nih.gov/313...
Indomethacin, another pain pill..was found to kill Androgen Resistant (Enza and Abi resistant cells) But this one is a prescription med and men with kidney damage can not take it. This article is from 2019.
What dose for humans would be equivalent if taken orally?
Too much ibuprofen is toxic - a friend of mine ended up in Emergency while he was trying to combat muscular pain - they told him to STOP taking it ...
So, the question is - how MUCH and for how LONG and is this still valid today ?
I note there was no 'bulk' number or dose level mentioned ....
Here is a balanced article which includes risks & benefits of NSAID's: hindawi.com/journals/aps/20...
So, if the ibuprofen would in fact be effective, it would apply only to prostate cancer that has metastasized to lymph nodes?
Combine it with green tea extract: pubmed.ncbi.nlm.nih.gov/182...
Combine it with chocolate chip ice cream (two scoops).....
Good Luck, Good Health and Good Humor.
j-o-h-n Wednesday 10/07/2020 6:48 PM DST
Hi leeLiam,
I read the article you posted -- that is impressive .. synergistic
" Results:
EGCG+ibuprofen treatment resulted in 90% growth inhibition, while ibuprofen or EGCG alone reduced cell numbers by 25% and 20%, respectively. EGCG+ibuprofen induced MAPK activation, caspase activation and the inhibition of Bfl-1 expression, all of which were blocked by the antioxidant, N-acetyl-L-cysteine (NAC). Moreover, addition of ceramide rescued the NAC-inhibited MAPK activation and pretreatment with the ceramide synthase inhibitor, fumonisin B1, reduced cell death.
Conclusion: Our results suggest that in DU-145 prostate cancer cells: (i) EGCG+ibuprofen treatment has a synergistic effect on apoptosis, and (ii) oxidative stress, directly or indirectly via ceramide synthesis mediates pro-apoptotic signaling. "
I guess I should consider switching from aleve (naproxen) to ibuprofen.
And take it with green tea -- couldn't hurt!
Ibuprofen can cause kidney damage and gastric bleeding. Take it with caution long term.
