Hi everyone....this is my 2nd post. Diagnosed with pca in September of 2018. Gleason 8 psa was very high. My MO started me on Lupron and Casodex in Oct. 2018. Psa taken on 1/18/19 now (2.0). I am tolerating this combo very well. My ONC wants to switch to Zytiga. Not sure how I will tolerate this combo plus the prednisone. I was told by my insurance company that a 3 month supply of Zytiga would cost $2200. I do have a supplemental cancer insurance policy that pays $40 per day for cancer drugs. Since Casodex and Zytiga block androgens from essentially the same areas (adrenal glands and the tumors themselves), do you think there is any more value in starting Zytiga or should I see how much lower psa will go with Casodex? There are no grants out there for Zytiga from Jansen at this time.