Did Untested Therapy Cure Advanced Br... - Advanced Prostate...

Advanced Prostate Cancer

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Did Untested Therapy Cure Advanced Breast Cancer?

George71 profile image
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" it is now clear that for multiple cancer types that are [resistant] to all known chemotherapies and immunotherapies, attacking the unique mutations in a patient's cancer can result in dramatic durable cancer regressions,"

webmd.com/breast-cancer/new...

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George71
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Tall_Allen profile image
Tall_Allen

City of Hope and others are designing clinical trials for CAR-T therapy. Here's a recent review:

ncbi.nlm.nih.gov/pmc/articl...

There are some clinical trials that are already recruiting:

clinicaltrials.gov/ct2/show...

clinicaltrials.gov/ct2/show...

George71 profile image
George71 in reply to Tall_Allen

yes, Car -T,

"Novartis was the drug company that partnered with the University of Pennsylvania to turn June's treatment into a drug for the general public, and the company submitted results of all three required levels of tests to the Food and Drug Administration early this year. If the FDA approves the drug, any child who has B-ALL and has failed her first therapy can have her white blood cells removed, frozen, and shipped to Novartis's processing facility in Morris Plains, New Jersey, where molecular engineers will insert the new "key" and send the T-cells back. The patient gets a one-time infusion, and there's an 83 percent chance she will be cured."

"We also do a second measure of remissions where we look to see if there's any measurable disease at all," says David Lebwohl, Novartis's global program head for CAR-T treatments. "A more sensitive test than just looking in the blood. And that was also negative for 83 percent of the patients."

"An 83 percent cure rate in children who would otherwise die is a monumental achievement. If there is a moment where a culture hits on an idea that can cure a disease—vaccines, for example, or penicillin—we are in it. It is difficult to overstate this: Humans have been trying to create a cell therapy for cancer patients for generations. "People said: That can't be done, You can't make them from cancer patients, You can't make them, You can't get them, It's too complicated," says Crystal Mackall. "But it's happening." Though Novartis couldn't confirm an official release date, Mackall suspects the drug will become widely available this year."

popularmechanics.com/scienc...

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