PSA rise on Xtandi

[joekaty]

4th month of Xtandi with declines each month until last week when it jumped from .78 (my nadir) to 1.05. MO says to start contacting our MD Anderson doc for trials. Any thoughts? Already had 10 rounds of taxotere. Wondering how long Xtandi lasted for others and when they determined it had failed?

[Tall_Allen]

I think that most MOs like to see radiographic evidence of progression too before they give up. Maybe Jevtana will re-sensitize.

[joekaty in reply to Tall_Allen]

Had an MRI and CT done last month due to increased shoulder and neck pain. MRI showed sclerotic lesions in marrow of cervical spine, but MO said that without correlating labwork (increased alk phos and PSA, decreased platelets, hemoglobin) he continues to believe they are healing areas that were treated. All other labs came back basically same other than increased PSA, but he did not make any other suggestions about treatment.

[Tall_Allen in reply to joekaty]

Sounds reasonable. 1.05 is still very low.

[RyderLake2]

Hello,

I have been on Xtandi for a year now. PSA still undetectable at less than .008. No serious side effects other than fatigue and the occasional hot flash. Fingers crossed for many more years.

[joekaty in reply to RyderLake2]

That is great!

[Magnus1964]

What other treatments have you had? It's hard to say without more information.

[joekaty in reply to Magnus1964]

Diagnosed stage 4 with metastasis to nodes, bone and bone marrow. Had 10 rounds of Taxotere- August 2017 to February 2018. Have been and still am on Lupron and Xgeva. Excellent response to chemotherapy. Two months after stopping PSA started to rise so was started on Xtandi and now 4 months later PSA rising.

[PLASTICMAN]

Hi there. I did four months of Xtandi and my PSA almost tripled from 2-something to 7.05. Then did taxotere (docetaxel) for four months and PSA hardly moved....7.05 to 6.95. Bone scan shows advance in mets. Had more bone pain in back. So started Zytiga (1000 mg./day)....fine so far...pain treated with methadone....and am set to have 10 sessions of mets radiation starting Friday (maybe). PSA now 17-something! It seems to me that what works for one person may not work for another. You've got to keep on trying!

[joekaty in reply to PLASTICMAN]

Has Zytiga decreased PSA? I did 10 rounds of Taxotere already, too many mets at diagnosis (one year ago) for radiation. On morphine XR twice daily and norco for breakthrough pain. Am starting cancer diet today! Keep fighting!!!

[PLASTICMAN in reply to joekaty]

Cancer diet! Tell us about it!

[joekaty in reply to PLASTICMAN]

It’s called “Chris Beat Cancer”. Full disclaimer- I have not read everything yet but I’ve made DRASTIC changes in my diet over the last week or so. Vegan, no sugar, refined carbs, processed foods. Basically fruit, vegetables, some beans and tonight had steel cut oatmeal. I have a long way to go with juicing and adding in spices but I’ve made a good start.

[joekaty]

Thanks all for responses- I added some additional information. Looking to be as aggressive as possible so appreciate the responses and welcome thoughts/suggestions!

[Ldtyson]

Is it possible to have a dictionary so the new people can understand all of these abreviations. I get completely lost on some of these posts.

[joekaty in reply to Ldtyson]

Yes it can be very overwhelming at first and then, unfortunately, you learn them all and you wish you hadn’t!

[j-o-h-n]

u r rght...

Gd Luk & Gd Hlth.

j- Thur 8/30/18 7 P

[Steph1234]

My husband did taxotere, zytiga for 8 mo, xtandi for 4 mo and now rechallenging Taxotere. He also had radiation twice. Doc determined xtandi failed when husband’s spine mets increased. PSA was not increasing at the time. I think zytiga may be something to inquire about. It was great for my husband.

[joekaty in reply to Steph1234]

Thank you. Sorry I missed this message earlier. Appreciate your reply. Will talk to dr about it.

[Ldtyson]

That's perfect. Now I have a better understanding of what people are talking about. Now if I can just figure out how to print this out I'll have it right by my side. There is no print function attached to the page.

[Dan59 in reply to Ldtyson]

Copy and past it into a word page and print from there

[Grumpyswife]

Some men are taking Xtandi with a statin, Avodart and/or Metformin.

[joekaty in reply to Grumpyswife]

Sorry I missed this message. I have heard of people taking metformin. Will inquire with onc when I see him in two weeks! Thank you!

[Dalph87]

PSA on Xtandi and Zytiga can bounce up and down sometimes, one rise followed by one drop means nothing, you have to start getting worried if it keeps increasing month after month.