Fluctuating psa with xtandi

[Poppi07]

My father has been on xtandi for 2 years and over the last few months his psa was rising steadily we assumed it was starting to fail however his last 3 appointments denoted slow steadily declines in his psa. Now oncologist wants to remain on xtandi and review in 6 weeks. Any insights or wisdom as to why this would be occurring? Thought this could be useful to share.

[Magnus1964]

It would be hard to say without knowing what changes occurred in his eating and lifestyle. But enjoy the decrease in PSA and stay on xtandi.

[Poppi07 in reply to Magnus1964]

Thanks yes trying to get the most out of it. He takes a heap of other supplements but wasn’t a change in regimen. I thought it was odd.

[Tall_Allen]

PSA can be erratic. The only sure sign that it's failing is if scans show more/bigger metastases.

[Poppi07 in reply to Tall_Allen]

Thanks yep I knew it can jump around but it really did go up consistently. Scans have remained stable.

[Shooter1 in reply to Poppi07]

Stable scans are great.... Mine not so much. Good luck to you and your dad/

[GeorgeGlass]

You could consider getting scans. If you’re not metastatic, you might be able to use those three consecutive psa scores to get on daralutimide.