Fenbendazole: Has anyone tried... - Advanced Prostate...

Advanced Prostate Cancer
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Fenbendazole

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Has anyone tried fenbendazole? I have been reading a lot about this “dewormer for dogs” that supposedly can inhibit cancer cells.

I’ve come across a lot of interesting information on this and I also personally know someone that claims they cured their small cell terminal lung cancer with this.

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AlanMeyer

Dear Hopeseeker,

I'd be very leery of trying drugs that have not been rigorously tested in humans for the specific disease in question. I suppose that if everything else has failed and imminent death is certain, it might be worth a shot. But even then it's always possible that an untested drug could cut the remaining time and make it more miserable. It would be a crap shoot with the odds against you.

I did a quick search and found an article about a drug very like fenbendazole tested for brain cancer at Johns Hopkins. See: americaninno.com/dc/johns-h...

Hopkins thought it might have promise but I noticed this in the article:

"Riggins says he can’t confirm that the drug works just yet, but he has high hopes for the future. So far patients have experienced few side effects, but the low doses given to people in the trial also haven’t forestalled tumors from forming."

As I understand it, most drugs that have had some beneficial effect against cancer in the test tube or in animals turn out not to be effective in humans. And a lot of those that do have very limited effectiveness and only for some patients.

As for curing small cell lung cancer, I'd need a LOT more evidence for that than a patient report. I once read a posting from a man who had created a whole website to tell the world that he cured his prostate cancer with a macrobiotic diet. When I questioned him about what other treatments he had he admitted that he also had radiation and ADT, but he didn't think that the radiation was actually aimed at his prostate. I asked if he had to take his pants down to get the radiation. I guess he did because very shortly after that he took down the website.

Patients don't always have a very scientific understanding of what happened to them.

Best of luck.

Alan

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Lightmun
Lightmun
in reply to AlanMeyer

Hi Alan, please see my post below. Riggins is "the guy" in the NPR/Hopkins story and the current study at Hopkins is addressing precisely the dosage issue you mentioned. Good stuff.

Lightmun

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AlanMeyer
AlanMeyer
in reply to Lightmun

Interesting stuff. I tend to be very skeptical until I've seen results from a clinical trial but it does at least look like there's some hope here.

Thanks.

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Greon
Greon
in reply to AlanMeyer

Maybe Alan works in a field that deals with Big Pharma.

It is my thought that Big Pharma has used the exact molecule found in Fenbendazole and found through testing and molecular manipulation...that they can, and have been for many years, been keeping "cancer on life support", and draining health insurance policies, gov't subsidies, all while allowing patients to ultimately succumb to death.

If any industry needs to be completely taken over and restructured, it's the pharmaceutical industry, beginning with the FDA.

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AlanMeyer
AlanMeyer
in reply to Greon

I agree that the pharmaceutical industry exists to make money and that profits are their motivation. However I don't believe that they've been keeping cancer on life support. In the first place, any pharmaceutical company that can cure cancer will make huge profits from that cure. There are no restraints on how much a company can charge for a drug and a patent on a drug that truly cured large numbers of cancer patients would be worth many billions of dollars.

In the second place, I think I know enough cancer biology to understand that cancer is an extraordinarily complicated disease - much more difficult than the diseases caused by bacteria and viruses. And the differences between different cancers and different patients with the same cancers make it very difficult to produce treatments that work for everyone. Look for example at how some people in this group have been in remission for decades on ADT while others blow through all available treatments in just a year or so.

Still, we do need to regulate the drug companies in new ways to make their interests align with those of patients rather than be in opposition to them. There are good proposals out there about how to do that if we can get Congress and the President to stop kowtowing to rich donors.

Alan

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paige20180

My understanding is that these drugs are so old there is no patent. Fenbendazole was developed in the 1960’s. Am I wrong?

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AlanMeyer

In theory, drug patents last 20 years from the day the patent application is filed, which is usually quite a few years before the drug is approved by the FDA. So, in theory, any drug patented before the year 2000 is out of patent. See: upcounsel.com/how-long-does...

In practice, drug companies often find ways to extend their patent or to extend their control even without a patent, for example by paying off generic drug manufacturers to leave their drug alone.

I found a record on an FDA website referring to Fenbendazole in 10/26/1979 so, yes, my understanding is that Fenbedazole should be out of patent.

Alan

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Canoehead

Don’t know about Fenben, but take a look at Niclosamide, a tapeworm medication receiving some buzz as an off label cancer drug. You might want to read “how to starve cancer” by Jane McClelland. It is compelling stuff, and I say this as a beneficiary of all the conventional treatments.

I don’t believe much of what the “integrative/wholistic” believers subscribe to, but to totally deny that cancer has a metabolic component which can be addressed through metabolic approaches, including nutrition, supplementation and off label use of drugs like Metformin is just naive and dangerous. McClelland’s writing is pretty technical, but the science seems solid.

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Canoehead
Canoehead
in reply to Canoehead

I should add that Niclosamide has poor oral bioavailability. A phase 1 trial investigating whether larger doses might help with castration resistance was terminated due to toxicity associated with those higher doses.

A cynic might argue that this trial was designed to fail, because Niclosamide is an old, cheap drug, and big Pharmaceutical will not profit. Draw your own conclusions.

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AlanMeyer
AlanMeyer
in reply to Canoehead

I wouldn't be one of the cynics on this one. The article is published free in PLOS ONE and full text can be seen here: ncbi.nlm.nih.gov/pmc/articl...

It looks like the raw data from the trial is included in the article so anyone can look at it. The funding statement is as follows:

"We acknowledge research support from National Cancer Institute grants P30 CA015704, P30 CA033572 and R50 CA221836; Pacific Northwest Prostate Cancer SPORE CA097186, The Prostate Cancer Foundation (including Young Investigator Awards to MTS and HHC); and Department of Defense Award W81XWH-16-1-0484."

I wouldn't expect that any of those organizations have skin in the game.

Based on the article, I wouldn't take Niclosamide for prostate cancer.

Alan

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Lightmun

Hi Hopeseeker,

You are indeed onto something very significant. The class of anti-parasitic drugs that includes both fenbendazole and mebendazole have attracted a lot of attention and research efforts since at least 2002, with an uptick lately due to at least two lab events, one at John Hopkins and another at Merck.

At Hopkins, some mice who had been embedded with cancer became infected with tapeworms and thus had to be treated with fenbendazole. Within a few days, the cancer tumors had disappeared, a "happy accident" to say the least.

At Merck, in an unrelated event, it was a little more intentional: researchers had simply been experimenting with various medicines in their repertoire and had found that fenbendazole had "batted 1,000" in eradicating cancerous tumors in mice.

The Merck experiment has led to a rapidly growing word-of-mouth reporting of self-medicated success stories with fenbendazole. At Hopkins, meanwhile, there is a 6-year study in progress to determine the maximum safe dosage for humans using mebendazole, an indication that the company is taking the potential for cancer treatment by this class of drugs quite seriously.

There have also been promising studies in America, the UK and, most recently, India using either fenbendazole or mebendazole.

I'm new to this blog so I'm not sure how much information to post at a given time so I'll stop for now, pending any further interest.

In the meantime, the links below are for:

1) an NPR article on the Hopkins happy accident event;

2) the 2018 study at Punjab University in India;

3) the blog site for a pioneer of the self-medicators inspired by the Merck study.

I hope this helps and would be glad to answer any further questions or concerns. I've been on this story for about 8 months and continue to be profoundly encouraged. In short, the science is solid and the hope is real.

npr.org/sections/health-sho...

nature.com/articles/s41598-...

mycancerstory.rocks/

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Hidden
Hidden
in reply to Lightmun

I’m aware of these studies and I am really wanting my dad to take fenbendazole. I know of 2 people now personally that have been able to put terminal cancer into remission. One had a brain tumor, the other lung cancer. Both extremely advanced with just months to live and both now in remission. I wouldn’t believe this, but I’ve seen it firsthand.

Joe Tippens is an Oklahoman. That’s where I live. He is helping a lot of people around here with his story.

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AlanMeyer
AlanMeyer
in reply to Hidden

Unlike most experimental treatments, this one seems to be an already approved drug that has been used for years - though I do see that there are potentially serious side effects. There is info about side effects in the FDA drug label.

Here's an FDA label for mebendezol: accessdata.fda.gov/drugsatf...

When I searched for fenbendazole on the FDA website all I found were documents pertaining to animals.

Here's a starting point for FDA searches: fda.gov/

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Lightmun
Lightmun
in reply to Hidden

Okay, Hopeseeker, Joe is where my interest began. After learning of my brother-in-law's advanced myeloma, Joe sent him an email detailing his story. Ever the skeptic, but intrigued, I emailed an old friend of my mine from the University of Pennsylvania football team who went on to become the head of the cell biology department at Rutgers University.

Thinking that a bit of well-explained science might help your dad be more open to a seemingly unorthodox approach, and that it might help you and others understand some of the cell mechanics, here's how that went:

After I had laid out Joe's tale in some detail, my friend initially warned me that things that seemed too good to be true often were. The next day, however, he emailed me again to say he was finding various trials that indicated there was serious scientific interest in the approach. He also began theorizing how it might work, based on his own life’s work that just happened to center around what turns out to be precisely the cellular mechanics that would be involved in explaining how a drug that basically attacks parasites could also attack cancer cells.

Eventually, he summarized as follows.

" a. Background I: The protein tubular assembles into the microtubule polymers that make the mitotic spindle during mitosis, in other words cell division. Cancer cells love to divide uncontrollably and so if you inhibit spindle formation, you inhibit division, and you inhibit cancer cells. This explains the use of vinblastin in chemotherapy cocktails. It also explains why there are so many side effects -- basically bumping off rapidly dividing cells.

b. Background II: Radiation treatment in cancer looks to damage DNA and cells that are rapidly dividing make them susceptible to radiation treatment. Radiation damages the DNA and that induces the cells to basically commit suicide (apoptosis) rather than continue dividing. The damage occurs through a molecular oxygen effect -- and thus poorly oxygenated tissue are more resistant to radiation. Tumors can have poorly oxygenated regions because they don't necessarily have organized blood vessels (vascularization). So if you can introduce chemicals that "add" oxygen to poorly oxygenated tissues the cells become more radiation sensitive.

c. The Skinny: The family of drugs in question have both of the above biological and chemical properties. Fenbendazole binds to tubulin -- although it binds tighter and better to parasite tubulin than mammalian tubulin. Thus, parasites have a tougher time surviving as their microtubules are prevented from assembling. Chemically, there is biochemical evidence that the drugs bind to DNA and that might make DNA more susceptible to breakage by radiation. So given these properties, you could build a hypothesis that the drugs might be useful as part of a chemo/radiation one-two punch.

Basically, it looks to have a role in regulating the process of transcription (Remember, Central Dogma of DNA leads to RNA leads to protein) leading to synthesis of messengerRNA (mRNA), which holds the sequence information to make protein. One protein in particular looks to play a role in the cell suicide (apoptosis) and so the drug may collude with things inside a cancer cell to promote death."

End of my friend's first batch of emails. Since then, he has become so intrigued that he has designed and run a couple small experiments at Rutgers last summer and has plans for larger format studies. When the Punjab University study showed up in Scientific American, it basically explores and confirms much of my friend's off-the-cuff theorizing. As he wrote later (after I sent him the study): "We have known about the "Punjab study" since August when the paper was published. The funny thing is they effectively did everything that was on our potential list of experiments. So effectively we now have a model paper to consider in our experiments."

So, again, serious science. Human trials, of course, will take years but because both fendbendazole and mebendazole are widely regarded for their extremely low toxicity, it appears that the risk/reward spectrum may favor giving it a try -- particularly when traditional medical options have run their course and, previous to that, perhaps as a concurrent approach.

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jdm3
jdm3
in reply to Lightmun

This site is an amazing resource to learn from. Thank you for the information. It's good to hear from people who know people who are credible.

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ElizabethPub

Really helpful and insightful thank you so much for sharing. I'm going to try this on my husband - his psa is at 1.5 following RP/RT/ADT

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jlngirl

Please keep us updated on your husband's progress if he does try fenbendazole. My husband just started SR and ADT this week. He was T3 Gleason 7 after RP. Doubling time now of 9 months. We are hoping for the best but preparing for the future!

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Watergirlmaui

How is your husband doing after trying this out a few months?

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ElizabethPub

he wont take it :( said it made him feel sick

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Spaceman210
Spaceman210
in reply to Hidden

What dose did they take?

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FRTHBST
FRTHBST
in reply to Spaceman210

Came across this blog post today: cancertreatmentsresearch.co... The author has specific discussion of potential dosage.

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Valerie-wei
Valerie-wei
in reply to Hidden

Hi Hopeseeker,

6 months passed, did your father tried the fenbendazole? recently, a report from DailMail mentioned the "dewormer for dogs' is warmly talked in China, and we, family members of cancer patients, really want to know it really can cures the authenticity of cancer?

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Hidden
Hidden
in reply to Valerie-wei

Hi Valerie-wei,

No he has not tried it. He is currently in the Vision trial doing lu-177.

Google Joe Tippens KOCO 5-fenbendazole and you will see a story on this that was just aired here in Oklahoma.

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jefft

Well it is only a hundred bucks to get started, we going to try it.

The concept of starving the anaerobic reception along with choking off miocondrial tubriculs, uping the p58 natural cell life killer. Everything you need to kill a worm just happens to be how you kill a cancer to. Wish us luck !

We'll be mixing it with 6 Doxil Chemo Treatments.

CBD, Vit E, and THC

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Hidden
Hidden
in reply to jefft

Please keep me updated if you don’t mind! Best of luck to you I hope it works. I personally know of three different people that had end-stage cancer and they claim this is what put them in remission.

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Jo_iQ
Jo_iQ
in reply to jefft

Hi Jeff, may I know what CBD you are taking? I'm trying to search CBD OIL in amazon but only get HEMP OIL and google told me that they are not the same.

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Neverquitcanuck

CBD can be obtained from many of plants of the Cannabis genus: hemp or,

for lack of better term, pot. Pot being the common recreational version.

Look for a reputable seller that will provide a certificate of analysis (CoA) of the base oil/extract. This should be only for the CBD oil/extract not the one that includes any filler oils such as MCT or hemp oil, which are used to dilute the CBD oil to allow accurate dosing. The CoA for your base CBD oil should also include a pesticide analysis.

This last point is very important due to the way the biomass (raw green) input has been grown. A lot of disreputable growers will add a multitude of pesticides, herbicides and fungicides to get better yield and outward appearance. Once the biomass is subjected to the extraction process all the compounds are concentrated and become part of the oil output.

If you find an oil that you feel comfortable with I would suggest getting it tested yourself to verify what you have purchased, approx. $150. Many jurisdictions in Canada and US have third party testing labs where you can take your samples. I have done this for the CBD oil concentrate that I diluted with MCT that my wife is using.

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GrumpyGrammy
GrumpyGrammy
in reply to Jo_iQ

CBD and Hemp oil are different things with different efficacy. CBD oil comes either from hemp with less than 3% THC (the stuff that makes you high), or from marijuana plants. Hemp CBD is legal in most states and there is some federal legislation on board to make it legal all over.

CBD can be from marijuana plants with a higher amount of THC. CBD from marijuana is only legal in some states either over the counter or medically. CBD of Cannabidiol which is an oil extracted from the plant with a chemical process. It has different properties than just hemp oil. Hemp oil is pressed from the seeds of the hemp plant. Difference besides efficacy is cost. Hemp oil is fairly cheap. CBD from hemp can cost more depending on its type. CBD oil has been shown to work on certain seizures (usually with some small THC content. It is also in its low THC mix shown to work on certain canine cancers. If I had a dog with cancer, I would certainly give it a try. Just not hemp oil. Dogs cannot tolerate THC, so the Hemp CBD is preferable. Some say it has an affect on some human cancers, particularly brain cancers. I know it has helped with me with an inflammatory condition that was not helped with anything else. I have been able to avoid meds that make me stupid or just do not help.

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Watergirlmaui
Watergirlmaui
in reply to jefft

Wondering how it’s going after taking the dewormer meds?

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beaverstate

fenbendazole has been around for decades and they have given much larger doses than Joe tippens took to humans in study for any adverse effect. what is a tip off that it is actually a strong anti-cancer agent for the tubule destabilization is that the "cousin" (menbendazole) was bought by another company not that long ago and the price for a 100mg pill went up from under 5 dollars to 389!!! hello.... fenbendazole is off patent so anybody can make it but I am not sure about the menbendazole patent info. I read that one study with prostate cancer found that it worked best when taken with Vitamin E succinate (they mentioned it must of had a synergy together for greater cell death than just fenbendazole alone). I would stock up on this stuff because it is surely going to be in high demand and price will climb. wonder how long it will take for the gov. to try to stop over the counter sales?? hehe

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johnscats

Do you know the dose to take by any chance john

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beaverstate

the pediatric study at John Hopkins with mebendazole (same family of anti-parasitic micro tubelle destabilizing) is giving 500mg tablets 3 times a day. (if the person were 150lbs (the age group was 1 to 21 years of age) that is about 22mg per kg of body weight a day. there was also some testing with fenbendazole on cancer (forgot specific cancer type) which said the most effective dosage in their study with just 3 dosage levels was the one that was 25mg per kg of body weight...Joe Tippens had the amazing result from aproximately 3mg per kg of body weight!!! (only 3 consecutive days each week). the mebendazole pediatric study on dosage (using the 1500mg per day dosage) mentions that potential side effects are: "although side effects are rare and the vast majority are reversible, they include stomach upset, decreased blood count, and elevated liver enzymes due to inflammation."....just FYI to consider. we started on the joe tippens dosage schedule and are increasing now monthly after seeing results of blood work.

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Jo_iQ

Hi Hopeseeker, I'm a daughter of a stage-IV Small cell lung cancer pain patient, my father is found to have the cancer in Jan 2019 and I just read Joe's story and kindly of obsessed by it. I'm now trying to purchase everything but not easy out side USA, it takes quite a lot time and I have to use alternatives.

May I know if you have ever tried it?

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hament
hament
in reply to Jo_iQ

Hi Jo

I am on the same boat as you

My father had been diagnosed with SCLC in January with metastatis to nearby lymphnodes

We have started with chemo n immunotherapy

But I am looking for some alternative.

Could you please update what treatment are you following?

Have you started with Fenbendazole?

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opbuff2002
opbuff2002
in reply to hament

I am just starting the Fenbendazole treatment. I have metastatic breast cancer in the liver which is usually terminal so it is worth giving this new thing a go. Will let you know how I get on. Next M R I due end of June so it will be interesting to see if any effect at that point. I will continue until end September, when my next Pet/Ct scan due.

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sorrybones

I also have MBC to the liver and am wondering about this treatment to use in conjunction with my conventional treatment. Do you mind sharing what dose you are using, and if you care combining it with any vitamins, or other supplements?

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luvhealth

I am interested in following your journey. My husband has just started Fenbendazole as well. He has already done one 4 day session with a week off. We had an anomaly in yesterday's blood report, his Alkaphase dropped significantly, back down from 190 to 117 in that two week period with intake of FB although PSA is still rising. He started taking Fenben again today with CBD oil. We have not included Vit E because many trials are showing Vit E is not good for prostate cancer. Are you including Vit E... I mean doing the complete protocol as recommended on Joe's website?

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ITCandy
ITCandy
in reply to luvhealth

100 mg tocotrienols would be more effective with fbz.

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luvhealth
luvhealth
in reply to ITCandy

I think you are right ITCandy. I've been doing research tonight and am now thinking we are making an error. I found this

ncbi.nlm.nih.gov/pmc/articl...

Supplemented vitamins included B, D, K, E, and A. Vitamins E and A both have antitumor properties by virtue of their antioxidant properties. Vitamin E causes antitumor and antimetastatic effects in several animal models of cancer; for example, it suppresses the nuclear transcription factor NFκB in prostate cell lines.

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airmanbear

What are the results now 8 months later of his psa???????

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luvhealth

He's PSA is over 3500 and we are now in the fight. Xtandi has completely failed and his Onc took him off of Xtandi, which can cause a spike. Chemo would be too hard on him so it is ruled out. So we have started back on Fenbendazole, added RSO and using Gerson Therapy. He is able to eat and juice and thrive although weak. We are going to have another blood test this Monday. We stopped FZ for a while during Oct - December. I feel that FZ isn't strong enough for mcrpc but can help slow things down. He is using the COC protocol - Metformin, Atorvastatin, Doxycyline and Fenbendazole right now.

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LouisaMay

Hi opbuff2002,

May I ask how your MRI went? I have metastatic BC with extensive bone mets, spots on liver and a hazy mesentery. I have ordered some Fenbendazole today and will be starting the protocol soon. My next scan is next March so I have plenty of time to see if it has any effect (currently on Letrozole & Ibrance).

Any thoughts you have would be greatly appreciated.

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hsam
hsam
in reply to LouisaMay

hi, any improvements after taking febendazole?

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LouisaMay
LouisaMay
in reply to hsam

Hi hsam, well it's really hard to know. I've been on it for almost 3 months now. My tumour markers are gradually going down, month on month. Last time I had them done almost a month ago, they were at 39. Under 30 is considered normal. Up till I started the fenbendazole, they were hovering at around 50.When I was first diagnosed in January they were at 73. Many people have much higher numbers and they are not always a reliable indicator. I feel fine in myself but then I always have. I think I have more energy then before I was on the fenbendazole. I will not really know until next March or so when my next scan is due. However, my orthodox treatment is not aiming at a cure, it is only aiming to give me some time before the 'inevitable'. So I now have hope which is transformative! I don't know how my story will end but the journey is certainly more fun with hope in my heart. Please give my best wishes to your sister. (If my March scan does not show the improvements I hope for and expect, I will up my dose of fenben. If that doesn't do the trick, I will look at Jane McClelland's method of blocking off all the pathways by which cancer feeds itself. Or Jim Gordon's herbal protocol. I'm not going down without a fight!).

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Watergirlmaui

Curious to know if you’ve seen any improvement after doing the Fenbendazole treatment? I’m considering

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LouisaMay

Hi, Watergirlmaui, Just to say, there is little or nothing to lose. Fenben is remarkably non-toxic and the required dose is small as it works at micro-molar concentrations. Good luck and best wishes with whatever you decide.

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hsam
hsam
in reply to opbuff2002

hi there, any improvements with doing the febendazole treatment? as my sister in same situation as you and i want to know if it helps so she can try it too, thanks

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nun11
nun11
in reply to opbuff2002

Hello can i ask how your MRI went? Cause i want my sister to take it?

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hament

Hi hopeseeker

I am new to this forum so doesn't know current health of your dad

How is he doing now?

Did he started Fenbendazole?

My father had been diagnosed with extensive sclc, so we are looking for some alternative treatments

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gettinginfo
gettinginfo
in reply to hament

My Dad started on Fenbendazole 4 weeks ago, per the protocol listed by Joe Tippens blog. We go to Oncologist on Wednesday next week for blood work and PSA. He previously tried Xtandi, which was a horrible drug that nearly killed him. Prior to that he was on Lupron. He stopped traditional treatments on Dec 7, 2018. His PSA has been climbing since then. Since he has been on the Fenbendazole, the swelling in his legs is gone and they are back to normal. HIs energy has increased and he feels much better. I will post more information next week when I have more evidence that Fenbendazole is working. He also takes Vit E as the research shows that Vit E and Fenbendazole worked better on prostate cancer.

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hament
hament
in reply to gettinginfo

Thanks for replying

Keep us updated about the progress

Hoping that it will work for your dad

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genesurf

gettinginfo, any updates?

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Watergirlmaui

Any more updates? I’m considering but skeptical.

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airmanbear

WHAT IS HIS PSA NOW AFTER 7 MONTHS OF FENBENDAZOLE

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Catswishes
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dpgast

I currently take it for advanced colon cancer. I started a blog that tracks my experience and links to articles about fenbendazole and cancer. You can read about my experience here: fenbendazole.home.blog

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Watergirlmaui

Saw on your blog that you discontinued the Fenbendazole regime? Why?

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SignMan

Been taking Panacure fenbendazole for 1 gram for 10lbs dog gram, 3 days on 4 days off. PSA numbers are coming down.

Had surgery scheduled and my doctor is postponing my surgery for prostatectomy. It's helping big time.

Believe it.

1 like
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dbfrav
dbfrav
in reply to SignMan

SignMan, how soon after you started the Fenbendazole did your PSA start coming down?

Thanks.

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Hidden
Hidden

I'm trying the drug now. So far no adverse side effects. In theory it should work well with my prostate cancer. My root genetic flaw if TMPRSS-ERG fusion. This has resulted in ERG+ which, in turn, makes my cancer resistant to taxanes but, interestingly (in theory), responsive to vincas and drugs such as Fenbendazole. These latter drugs function by a different mechanism, distrupting microtubule formation prior to cell mitosis.

I'm sceptical of the drug's bioavailability. It isn't water soluble so is absorbed in low quantities. This makes me equally sceptical of the widely disseminated and reported results.

Neverthless I'll give it a try and monitor PSA (which in my case is a good indicator of prostate cancer progression).

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Hidden
Hidden
in reply to Hidden

So far so good.

Last prior PSA:

11/22/2019 588.10 ng/mL

PSA after 10 doses

222 mg per dose once a day (in water or mango juice), 5 days on, 2 days off:

01/17/2020 37.71 ng/mL

The only concurrent treatment is a Trelstar injection.

Testosterone level <3.0 ng/dL

Normal level 193.0-740.0 ng/dL

No adverse side effects (neutropenia, etc) thus far.

I'm pleasantly surprised that I appear to be having a positive response to the drug. I'm not a big believer that the so called "rule of three" (3 days on, 4 days off) has any therapeutic meaning to treating cancer. I chose 5 days only because I felt tired after 5 days and was concerned that my exhaustion was due to neutropenia. A CBC after my second 5 day series of doses indicated normal WBC (7.84 k/uL). This demonstrates that my exhaustion was due to a cause other than neutropenia

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mjbach
mjbach
in reply to Hidden

Hi Jim, My husband has the same TMPRSS-ERG genetic flaw plus PTEN deletion. He started FENBEN last August along with Zytiga + prednisone. His PSA dropped for a few months but is now rising. He just switched prednisone out for a different steroid so we will see....

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Hidden
Hidden

"Inhibition of AKR1C3 Activation Overcomes Resistance to Abiraterone in Advanced

Prostate Cancer" - tinyurl.com/v62f95a

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