Concentrated sugars (!) & PCa.

[pjoshea13]

New paper from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial.

We know that prostatic cells prefer fatty acids as fuel & that radio-labeled glucose PET can't be used to diagnose PCa, so what to make of the new study?

Note that:

"There were no linear associations between prostate cancer risk and consumption of sugars from fruit juices or dessert foods."

However, "consumption of sugars from sugar-sweetened beverages was associated with increased risk of prostate cancer among men receiving standard medical care."

The term "sugar" is often used loosely. For instance, why do so many papers refer to blood "sugar" when they mean "glucose". In the case of beverages, does "sugar" mean sucrose alone, or does it include high-fructose corn syrup? But in high enough doses, both will affect markers of the metabolic syndrome & increase PCa risk. Perhaps the issue is the size of the glucose challenge that can follow these drinks, & the size of the insulin response.

-Patrick

ncbi.nlm.nih.gov/pubmed/300...

Br J Nutr. 2018 Jul 26:1-8. doi: 10.1017/S0007114518001812. [Epub ahead of print]

Concentrated sugars and incidence of prostate cancer in a prospective cohort.

Miles FL1, Neuhouser ML2, Zhang ZF1.

Author information

1

1Department of Epidemiology,Fielding School of Public Health,University of California,Los Angeles,CA 90095-1772,USA.

2

2Cancer Prevention Program,Division of Public Health Sciences,Fred Hutchinson Cancer Research Center,Seattle,WA 98109,USA.

Abstract

The association between consumption of added or concentrated sugars and prostate cancer risk is unclear. We examined the association between concentrated sugars in beverages and desserts and prostate cancer risk among 22 720 men in the usual-care arm of the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial, enrolled during 1993-2001. After a median follow-up of 9 years, 1996 men were diagnosed with prostate cancer. Cox proportional hazards regression models were used to estimate hazard ratios (HR) for prostate cancer risk and 95 % CI, adjusting for potential confounding factors. Increased consumption of sugars from sugar-sweetened beverages was associated with increased risk of prostate cancer for men in the highest quartile of sugar consumption (HR: 1·21; 95 % CI 1·06, 1·39), and there was a linear trend (P<0·01). There were no linear associations between prostate cancer risk and consumption of sugars from fruit juices or dessert foods. In conclusion, in this prospective substudy within the PLCO trial, consumption of sugars from sugar-sweetened beverages was associated with increased risk of prostate cancer among men receiving standard medical care. Our study suggests that limiting intake of sugars from beverages may be important in the prevention of prostate cancer.

KEYWORDS:

Colorectal and Ovarian; DHQ diet history questionnaire; HR hazard ratio; Lung; PLCO Prostate; PSA prostate-specific antigen; Added sugars; Proportional hazards regression; Prospective cohorts; Prostate cancer risk

PMID: 30047347 DOI: 10.1017/S0007114518001812

[Hidden]

Here we go.......

[pjoshea13 in reply to Hidden]

Yes ...

I figured that the media will be all over the study & that the sugar myth fans will start posting again. Hence the preemptive post.

We will see.

-Patrick

[cesanon]

I'm not certain I get it.

Cabonated beverages are bad but deserts and fruit juices are ok?

Data is self reported dietary patterns?

[j-o-h-n in reply to cesanon]

Post from cesanon: (approximately 12 PM)

John I guess everyone sees a different purpose for this forum. And certainly there are many competing opinions. But if you post things with no opinion I submit to you that that is spamming it.

Please consider contributing your opinion when commenting.

I know you think you are contributing humor, but I am fairly certain the only person seeing the humor is you. Perhaps you may have noticed that you self?

Go do what you want, but please consider contributing substance to the dialog.

Thanks

My Post in response:

Thank you for your critique but I fight my disease with humor. Whether or not you appreciate my posts is not my concern... it's yours. I would suggest that you ignore my post by merely bypassing them when you see them (it's easy, try it). If you don't like my humor then all I can say is c'est la vie.

Good Luck and Good Health.

j-o-h-n Saturday 07/28/2018 9:40 PM EDT

[j-o-h-n in reply to cesanon]

Post from cesanon (approximately 11:30 PM)

Sure. I got your message. A little touchy aren't we? LOL But that is OK.

You go write whatever you want. That's what I do. I privately ask you to consider refraining from spamming, so you respond with an off-topic spam. I guess you told me off. LOLOLOLOL

Still off topic spam is off topic spam.

Its just that I find watching your postings is sort of like watching roseanne barr's series of appologies to valerie jarrett. Who exactly is she speaking to? And if so, why then say what she is saying. If you are appologising, why would your appology include a new insult?

I guess it takes all kinds.

But I am certain you have opinions on the subject of prostate cancer, I encourage you to express them.

My Post in response.

I don’t know what you’re smoking but it must really be expensive.

Good Luck and Good Health.

j-o-h-n Saturday 07/28/2018 11:36 PM EDT

[ITCandy in reply to j-o-h-n]

Might have been laced with pcp...

[Hidden in reply to ITCandy]

That's funny.

[j-o-h-n in reply to ITCandy]

Hmmmm good thought. Thanks.

.............................................................................................................................................

Humor!

Just for general information: Dr. Timothy Leary the LSD guru was diagnosed with inoperable prostate cancer in January 1995 (died May 1996).

Dr. Leary's last book before he died was Chaos and Cyber Culture, published in 1994. In it he wrote, "The time has come to talk cheerfully and joke sassily about personal responsibility for managing the dying process."

Good Luck and Good Health.

Sunday 07/29/2018 12:28 PM ED

[j-o-h-n in reply to cesanon]

Post from cesanon

(approximately 8:00 AM - 07/29/2018)

John

May I commend you to this forum to share your upbeat idiosyncratic humor. It will be most definitely be on topic there:

healthunlocked.com/anxiety-...

thank you

My Post in response:

You don’t have to thank me, I thank you for the recommendation.

Good Luck and Good Health.

Sunday 07/29/2018 12:09 PM EDT

[pjoshea13]

I doubt that anyone here will defend sugar as a health food.

(Those addicted to supersized super-sweetened soft drinks should worry about more pressing health concerns than PCa.)

-Patrick

[AnnieAppleseed]

I am absolutely positive that sugar/glucose/high fructose, NOT fruit, will be found to be problemmatic for those of us with cancer. The evidence is slowly building, but any conclusion is only as good as the studies. If a PET scan uses glucose (aka sugar) along with radioactive materials to find cancer cells, you have to realize that sugar/glucose is what FOUND the cancer cells. I am a 25 year (breast) cancer survivor and so many of the things the alternative medicine world focused on, have been shown to be accurate in that time. I was told it didn't matter what I ate (not true), exercise was a bad idea (not true) that my immune system didn't matter (not true) and that Yoga "might kill me" (not true). More and more concepts are moving into true. Avoiding added sugar will soon be too. Personally I am persuaded. Long ago I was told to WAIT for the evidence. Since Big Pharma will not study (nor spend money) on anything they cannot patent, the trials I sought 25 years ago, are still to be done. I no longer wait.

[Hidden in reply to AnnieAppleseed]

Thank you for your succinct overview Annie and your book.

[AnnieAppleseed in reply to Hidden]

I am not the Annie who wrote Healing Platform if that is what you refer to. That's Annie Brandt, Exec Dir of Best Answer for Cancer. I am the founder of all-volunteer cancer nonprofit Annie Appleseed Project.

[j-o-h-n]

Not wanting to sugar coat the conversation about sugar but I think you should call your spouse honey instead of sugar.

Good Luck and Good Health.

j-o-h-n Saturday 07/28/2018 1:29 AM EDT

[leo2634]

I eat and drink whatever I want now. I always was mindful of my diet before PC and look what that got me. I now go by the saying life's too short enjoy it while you can which certainly applies now. That's just my opinion. I asked my MO if I should restrict my diet in any way and he said to eat anything I wanted but in moderation. I love this forum and its conversations and look forward everyday to reading the.. I wish all my Brothers in arms here the best of life has to offer. Enjoy life my Brothers. Leo

[whatsinaname in reply to leo2634]

I am 100% with you, leo2634. Your logic is impeccable. If you took great care of your diet and yet got PC, how will continuing the same diet cure PC ? Or even keep it dormant ?

Eat and drink whatever you want. At least I will, for sure. Cheers, leo2634.

[leo2634 in reply to whatsinaname]

I do . Please excuse any typos my fingers are sticky from dunking my Oreos in my coffee lol.

[AnnieAppleseed in reply to leo2634]

I am sure we can all agree that causes of cancer are complex. I like to think that my eating a reasonably healthy (but nowhere near 'perfect') vegetarian diet helped from dying despite developing 25 tumors overall - 14 AFTER mastectomy. I think I am the 'Tumor Queen' of North America. Still here after more than 25 years. I cannot control (fully) the external environment, but I can control what I eat and what I get exposed to, in my own home. WHY not? Many studies show the value of say the Mediterranean Diet for better health. We who have had cancer need more help than the other folks. Good luck.

[larry_dammit]

Doesn’t really say much to me, my dietician said eat anything I can to keep up my weight ,when I told her I liked my pie and ice cream she said good. Go ahead 😀😀

[leo2634 in reply to larry_dammit]

As long as its Apple Crumb pie with 100 % pure ice cream don't feed me that lite or fat free stuff I'll know the difference lol. Enjoy Brother.

[larry_dammit in reply to leo2634]

Yep. Have to enjoy life every day 😜😜😜😜😜

[AnnieAppleseed in reply to larry_dammit]

Must disagree with less than well-educated dietitian. So many studies indicate WHAT we eat matters every step of our lives. See my post above re my own habits.

[Currumpaw]

Really! Make that two scoops on a sugar cone?

An interesting article about Metformin and it's ability to slow the progression of prostate cancer. It seems to force the cancer cells to use their supply of sugar sending them into apoptosis. It is suggested the best time to take it is when your blood sugar levels are low increasing the effectiveness of the drugs ability to kill the cells. Dessert anyone? Wouldn't want those cancer cells to be deprived would we? It would seem to be prudent to stick with whole fruits for sugar.The article was recent. Not something five years old.

Here is the link: Copy the everything between the lines.

________________________________________________________________________

Drug shows promise in zapping prostate cancer - newsday.com

newsday.com/news/health/pro......

__________________________________________________________________________

Currumpaw

[jdm3 in reply to Currumpaw]

That link didn't work for me. I am interested in this because trying to have an intelligent conversation with my MO about Metformin. Thanks.

[pjoshea13 in reply to jdm3]

Try: newsday.com/news/health/pro...

-Patrick

[Currumpaw in reply to pjoshea13]

Try it now. Copy everything between the lines. LifeExtension also has some good articles backed by studies that you can access. Dr. Snuffy Meyers' patients had good results with Metformin he prescribed for them.

Research statins. They are also helpful.

Currumpaw

[jdm3 in reply to pjoshea13]

Thanks.

[Litlerny]

I read something recently from my Mayo Clinic patient portal that there is no correlation between why they use a sugar based contrast in PCa scans and sugar as being a driving force in either causing PCa or accelerating the progression of PCa if you already have it. Not sure what to make of it.

[AnnieAppleseed in reply to Litlerny]

Some of us find that 'logic odd.

[Litlerny in reply to AnnieAppleseed]

Tell that to the Mayo Clinic. I didn’t write the article, just stating what I read. It was written by Dr. Timothy Moynihan at the Mayo Clinic as part of a list of cancer myths. You can Google it yourself. Some of us find it odd? Who are they?How many? I think some of the people in here are odd.

[AnnieAppleseed in reply to Litlerny]

Of course Mayo wrote it. As a 25 year Advocate I often feel like I straddle three columns. The first, mainstream, the 2nd Integrative (use of complementary therapies studied during conventional treatments), and the 3rd Holistic, often called alternative. So much dismissal of new ideas in group 1. Group 2 does studies of natural concepts, but as though they were pharmaceutical products, i.e. looking for 'active elements' rather than whole substance or food. And a study out of MD Anderson looked at mice given human tumors. One group got added sugar, one group did not. Sugar-fed group had larger tumors and earlier death. Researchers are having difficulty getting funding to do a human trial. That's seems awful when this is a question we all have. 20 years ago I asked for RCT on the use of antioxidants with chemo. Never happened. Instead years of speculation instead.

[Litlerny in reply to AnnieAppleseed]

Very interesting! Thanks for sharing that. And the conflicts and questions just seem to continue on and go unresolved, to the detriment of all of us who are Stage 4 patients. Best wishes to you.

[AnnieAppleseed in reply to Litlerny]

That is just so sadly true. Big Pharma has no interest in natural since it cannot be patented. Researchers work to create a drug but they have to CHANGE aspects to be able to patent. The changes always seem to cause toxicity. And mostly natural substances go with other natural substances. One reason vitamin trials are so badly done, is that they try one element alone. They are meant to work in synergy/concert with each other. I chose to eat organic, to be mostly plant-based (now just about 100%), etc. Good wishes.

[Hidden]

I gave up fizzy sugar water years ago when my gut, on an otherwise slender frame, made me look pregnant. So I drink water at meals with some prune juice thrown in for regularity. That said, I am still a bit of a sugar addict, scarfing chocolate nuggets and other sugary stuff. I just find it difficult to completely swear off treats. It doesn't help that my wife doesn't shop healthy -- the battle is lost at the grocery store.

[AnnieAppleseed in reply to Hidden]

I suffered from constipation most of my life as well as 10 years of diarrhea. I suggest taking a look at this page from our cancer nonprofit Annie Appleseed Project - may help regularize. Also consider probiotics - either capsules or fermented foods like sauerkraut (or both). annieappleseedproject.org/w...

[Litlerny]

A big amen to all of that. It’s all money driven. Like you, I am trying to transition to a more organic, vegetable based diet. Keep up the good work. 😃