Vasectomy & PCa risk: a meta-analysis of prospective studies

[pjoshea13]

New study below [1].

"In conclusion, findings from this meta-analysis of prospective studies indicate that vasectomy may be positively associated with the risk of prostate cancer."

"A total of 15 eligible cohort studies (16 datasets) with more than four million of participants were eventually included in this meta-analysis."

There was a 9% risk increase after vasectomy.

"Vasectomy was also associated with the risk of advanced prostate cancer (RR 1.07 ...), which is less likely to be affected from detection bias."

-Patrick

[1] pubmed.ncbi.nlm.nih.gov/327...

Carcinogenesis

. 2020 Aug 9;bgaa086. doi: 10.1093/carcin/bgaa086. Online ahead of print.

Vasectomy and prostate cancer risk: a meta-analysis of prospective studies

Sheng Cheng 1 , Bo Yang 2 , Liwei Xu 1 , Qiming Zheng 1 , Guoqing Ding 1 , Gonghui Li 1

Affiliations expand

PMID: 32772072 DOI: 10.1093/carcin/bgaa086

Abstract

Epidemiologic cohort studies investigating the association between vasectomy and prostate cancer risk have yielded inconsistent results. The aim of the present meta-analysis is to update the evidence on the association between vasectomy and prostate cancer. A comprehensively literature search of relevant studies was performed in December 2019 using PubMed. A DerSimonian and Laird random-effects model was used to calculate the summary relative risk (RR) and its 95% confidence interval (CI). A total of 15 eligible cohort studies (16 datasets) with more than four million of participants were eventually included in this meta-analysis. There was a statistically significant higher risk of prostate cancer among men who underwent vasectomy (RR 1.09, 95 % CI 1.04-1.13) with obvious heterogeneity among included studies (P < 0.001, I2 = 64.2%). Vasectomy was also associated with the risk of advanced prostate cancer (RR 1.07, 95 % CI 1.02-1.13), which is less likely to be affected from detection bias. In conclusion, findings from this meta-analysis of prospective studies indicate that vasectomy may be positively associated with the risk of prostate cancer. Further large prospective studies with long follow-up are warranted to verify the findings from this meta-analysis. In addition, the potential underlying molecular mechanism needed further exploration with in vitro and animal studies.

Keywords: Vasectomy; cohort; meta-analysis; prostate cancer.

© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For Permissions, please email: [e-mail].

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I had a big V in my thirties. A little late for this news now.

[pjoshea13]

From my reading I feel that there is risk based on age/ duration. That's not because my vasectomy was at age 30 & my PCa was diagnosed 26 years later.

When the first study came out there was panic. Imagine if men refused to have vasectomies? The effect on womens health, family size in poor nations, etc.

There was a concerted effort to discredit the study & spin the findings. I'm a bit cynical about the coverage.

But there are so many male risk factors: height for instance. & age (LOL).

Did you know that length of marriage is a risk factor too?

Vasectomy & marriage tend to go together I think. Plenty of opportunity for the exchange of body fluids. Two healthy individuals, say, but transfers of not so innocent bacteria or viruses that easily end up in the prostate & tend to hang around.

Who knows?

Anyone remember Leslie Nielsen's safe sex scene - the full-body condom?

-Patrick

[vforvendetta in reply to pjoshea13]

"Anyone remember Leslie Nielsen's safe sex scene - the full-body condom?"

Hah, yes I do! Thank you for the laugh, and thanks as always for the research and thoughtful discussion.

I'm holding off on the vasectomy for as long as I can. I'm 47, the alternative (condom) sucks, but my wife and I make do :-). She doesn't want to go on birth control, and I can't blame her.

[j-o-h-n]

A vasectomy isn't necessary......just eject when you ejac.....timing and speed my dear Watson... just timing and speed....

Good Luck, Good Health and Good Humor.

j-o-h-n Tuesday 08/11/2020 5:02 PM DST

[YorkshireGuy in reply to j-o-h-n]

Lol, though to be fair that's a bit like the worst promise in the world, "I promise not to cu m in your mouth"

[j-o-h-n in reply to YorkshireGuy]

And to French kiss you when we're through......

Good Luck, Good Health and Good Humor.

j-o-h-n Tuesday 08/11/2020 6:20 PM DST