Had a consultation with my specialist today. An almost throw away comment at the end around diet was to avoid soy products, potentially peanuts and chickpeas, due to phytoestrogen.
medicalnewstoday.com/articl...
Im on a largely plant based diet and these ingredients feature quite heavily, so I'd be interested in opinions on this.
That article left me totally confused....don't know if it's my lupron fog or my Xtandi fog... but it appeared to say nothing 😋....but it did make me crave a handful of peanuts...LOL.
John
It was found to be associated with the INITIAL development of advanced PC, but not non-advanced PC:
onlinelibrary.wiley.com/doi...
But the question you would be more interested in is whether soy isoflavones are beneficial in men already diagnosed with PC.
This study found no effect:
ncbi.nlm.nih.gov/pmc/articl...
These studies found reduced PSA:
tandfonline.com/doi/abs/10....
goldjournal.net/article/S00...
sma.org/southern-medical-jo...
But this one did not:
journals.plos.org/plosone/a...
There is a plausible reason for an effect based on lab studies:
ncbi.nlm.nih.gov/pmc/articl...
I haven't seen anything indicating any harm associated with men with PC using it. It may be particularly beneficial when used in conjunction with radiation.
thanks for the clarification...that was sort of what my foggy brain was thinking.
John
What is the reasoning against soy and for peanuts?
Genistein is known to have a biphasic effect. Physiological levels, as from diet, can promote PCa (& BCa), whereas pharmacological doses inhibit.
cancerres.aacrjournals.org/...
-Patrick
I use soy milk daily in my coffee rather than dairy so I go through a lot of soy milk, probably a gallon a week. I also use a good amount of all natural peanut butter. So far so good, PSA undetectable for close to 4 years.
When I asked Dr. Myers about them a while back he had no problem, said both were good sources of plant protein. Just gotta watch the peanut butter, too much puts weight on.
Ed
The soy isoflavones are a phytoestrogen, meaning they can act similar to estrogen in the body. For women with androgen-dependent cancers—e.g., breast cancer—this would be a big no-no since their disease ‘feeds’ on estrogen. For men with PCa, however, whose androgen sensitivity is predominantly to testosterone, estrogen can apparently have a cancer suppressing effect. Dr. Myers had me on estrogen patches at one point as one component of combination therapy, so he clearly felt estrogen (in higher concentration than a supplement, obviously) was useful in treatment.
As an aside, I stopped the patches after a couple of months when my breasts started to swell and my nipples became so sensitive that it was uncomfortable to put on a shirt. Dr. Myers recommended adding another drug to suppress the side effect, but I’m not a fan of 2nd and 3rd tier medications whose job is not theraputic to my primary cancer but to counteract the SEs of the previous meds, so I discontinued the patches. That was several years ago. Its unclear if adding the estrogen would have had a long-term beneficial effect or not.
For what its worth, I take a soy isoflavone capsule morning and evening along with lycopene. Again, this is one of those ‘shot-in-the-dark’ things that my onc calls ‘fluffy’ treatment. “Fluffy” = Maybe it will help and maybe not, but probably won’t hurt. (If I ‘think’ it works, maybe that mysterious placebo effect will kick in a do some good, even if the supplement has nothing to do with it. 
May even help with bone density. After one year of lupron dexa bone density higher than a 20 year old and I am pushing 80. Of course I circuit resistant train too. Rocco
Been eating all three + supplement for 18 yrs and still here. Rocco
80 mg. Swanson has one with 123 mg. Rocco
After a recent article on this forum, I researched the advantages of Vitamin K2 and it's positive effect on PCa cell apoptosis and bone health. I have added one heaping teaspoon of natto to my daily regimen. This provides 170 mcg of K2. Linus Pauling Institute recommends 150 mcg K2 daily. Natto is a Japanese dish (fermented soy beans) and is the richest source of K2 I could find. I mix it with a little peanut butter to make the taste more agreeable. This is the only soy in my diet.
My prostate cancer history outline is:
Gleason 4/4 with positive margins. RALP in 2008.
PSA started rising, so had IMRT plus 1 year on Lupron Depot. PSA < .006
Cancer recurred 3 years later in 2011. PSA 1.87
I went on Androgen Deprivaton Therapy (ADT4) in 2011.
Lupron, Casodex, Avodary, Cabergoline.
Monthly Lupron (7.5mg) caused no side effects. PSA <0.006 Testosterone < 3.0
Switched from Casodex to Nilutamide 2 years later when PSA started elevating.
PSA dropped back <.006 within 4 months. T < 3.
Provenge in 2014. I had an apherisis catheter (port) for the 3 Provenge procedures.
I added Metformin to my regimen in 2015.
Stopped Lupron Oct 2016, but continue all other medications in my regimen.
PSA <0.006, T =41 in May 2018.
Clint
I believe Japan has a much lower rate of prostate cancer than the US and they have lots of soy in their diets.
Diet
Diet book
No fibre diet
