Thoughts on newer F18 PSMA-1007 PET/CT Scan

[Mooserj]

Has anyone done or have information about f18 PSMA-1007 Pet/CT scan for recurrent PCa. I am in Thailand and the caner center that I was going to have my GA68 Pet/CT scan at to find the source of biochemical recurrence (PSA 0.89 two years after RP & 5 month doubling time) advises they now do this new scan instead. They report it is easier to work with and provides superior imaging?

Seems limited info on Dr Google - but what is available suggests it is a comparable scan technology - potentially clearer image and has found lymph node metastases at very low PSA levels.

Any views on this appreciated.

[cesanon]

Mooserj,

1. Would you post links to the information on the f18 PSMA-1007 Pet/CT scan that you found on Google.

2. Perhaps you can ask the people at the caner center what studies they are relying on?

[Mooserj in reply to cesanon]

Here is a case study using this technology

clinical-genitourinary-canc...

Another article

europepmc.org/abstract/med/...

[Tall_Allen]

Yes, what they say is true. An F-18 PSMA-based scan is superior to an Ga-68 PSMA-based scan because the radioemitter is better and is chemically bonded rather than chelated, and the PSMA-1007 ligand has greater specificity than the PSMA-HBED-CC ligand:

jnm.snmjournals.org/content...

[Mooserj in reply to Tall_Allen]

Thanks for the response and article - seems the next leading edge PSMA scan. Will be interesting to see the results in a few weeks.

[Tall_Allen in reply to Mooserj]

Yes - please let me know how it goes. The DCFPyL PET is a similar scan with similar advantages. The pce with which they are developing new PET indicators is wonderful!

[cesanon in reply to Tall_Allen]

Tall Allen, what do you know about the side effects of the psma scans?

The lu177 psma treatments seem to have some real problems with potential damage to salivary glands and kidneys.

[Tall_Allen in reply to cesanon]

I haven't heard about ANY side effects from PSMA scans. Positrons are non-toxic at dosages given in PET scans.

As for the Lu-177-PSMA treatments, the newer ligands are less toxic. With the new I&T ligand, 18/121 patients (15%) had serious or life-threatening hematotoxicity, affecting red blood cells (10%), platelets (4%), and white blood cells (3%). Such hematotoxic effects are the result of cancer and chemo (and Xofigo) as well, so it's not clear how much was due to the Lu-177-PSMA- I&T. Xerostomia (loss of saliva), a transient effect, occurred in 8%. Even with the older PSMA-617 ligand, renal toxicity was not a problem up to 40 GBq (4 cycles) - it is cleared from the kidneys within 48 hours .

On the plus side, it relieves pain from mets and reduces PSA in many patients.

[Hidden]

I had it last year. Much higher sensitivity. Showed what bone and ct scans did not