Resistance training impact on ADT symptoms.

[pjoshea13]

New study below.

"Prostate cancer patients on androgen deprivation therapy (ADT) experience adverse effects such as lean mass loss, known as sarcopenia, fat gain, and changes in cardiometabolic factors that increase risk of metabolic syndrome (MetS). Resistance training can increase lean mass, reduce body fat, and improve physical function and quality of life, but no exercise interventions in prostate cancer patients on ADT have concomitantly improved body composition and MetS."

"Prostate cancer patients on ADT were randomized to resistance training and protein supplementation (TRAINPRO), resistance training (TRAIN), protein supplementation (PRO), or control stretching (STRETCH). Exercise groups (EXE = TRAINPRO, TRAIN) performed supervised exercise 3 days per week for 12 weeks, while non-exercise groups (NoEXE = PRO, STRETCH) performed a home-based stretching program. TRAINPRO and PRO received 50 g⋅day- 1 of whey protein."

Why would protein supplementation help? - unless the diet was deficicient? It is not a lack of protein that causes sarcopenia.

"A total of 37 participants were randomized; 32 participated in the intervention (EXE n = 13; NoEXE n = 19). At baseline, 43.8% of participants were sarcopenic and 40.6% met the criteria for MetS. Post-intervention, EXE significantly improved lean mass (d = 0.9), sarcopenia prevalence (d = 0.8), body fat % (d = 1.1), strength (d = 0.8-3.0), and prostate cancer-specific quality of life (d = 0.9) compared to NoEXE (p < 0.05). No significant differences were observed between groups for physical function or MetS-related variables except waist circumference (d = 0.8)."

-Patrick

ncbi.nlm.nih.gov/pubmed/296...

BMC Cancer. 2018 Apr 3;18(1):368. doi: 10.1186/s12885-018-4306-9.

Impact of resistance training on body composition and metabolic syndrome variables during androgen deprivation therapy for prostate cancer: a pilot randomized controlled trial.

Dawson JK1, Dorff TB2, Todd Schroeder E3, Lane CJ4, Gross ME5, Dieli-Conwright CM3,6.

Author information

1

Divison of Biokinesiology and Physical Therapy, Ostrow School of Dentistry, University of Southern California, 1540 Alcazar Street, CHP-155, Los Angeles, CA, 90033, USA. [e-mail].

2

Norris Comprehensive Cancer Center, Keck School of Medicine (KSOM), Los Angeles, CA, USA.

3

Divison of Biokinesiology and Physical Therapy, Ostrow School of Dentistry, University of Southern California, 1540 Alcazar Street, CHP-155, Los Angeles, CA, 90033, USA.

4

Department of Preventive Medicine, KSOM, Los Angeles, CA, USA.

5

Ellison Institute for Transformative Medicine, KSOM, Los Angeles, CA, USA.

6

KSOM, University of Southern California, Los Angeles, CA, USA.

Abstract

BACKGROUND:

Prostate cancer patients on androgen deprivation therapy (ADT) experience adverse effects such as lean mass loss, known as sarcopenia, fat gain, and changes in cardiometabolic factors that increase risk of metabolic syndrome (MetS). Resistance training can increase lean mass, reduce body fat, and improve physical function and quality of life, but no exercise interventions in prostate cancer patients on ADT have concomitantly improved body composition and MetS. This pilot trial investigated 12 weeks of resistance training on body composition and MetS changes in prostate cancer patients on ADT. An exploratory aim examined if a combined approach of training and protein supplementation would elicit greater changes in body composition.

METHODS:

Prostate cancer patients on ADT were randomized to resistance training and protein supplementation (TRAINPRO), resistance training (TRAIN), protein supplementation (PRO), or control stretching (STRETCH). Exercise groups (EXE = TRAINPRO, TRAIN) performed supervised exercise 3 days per week for 12 weeks, while non-exercise groups (NoEXE = PRO, STRETCH) performed a home-based stretching program. TRAINPRO and PRO received 50 g⋅day- 1 of whey protein. The primary outcome was change in lean mass assessed through dual energy x-ray absorptiometry. Secondary outcomes examined changes in sarcopenia, assessed through appendicular skeletal mass (ASM) index (kg/m2), body fat %, strength, physical function, quality of life, MetS score and the MetS components of waist circumference, blood pressure, glucose, high-density lipoprotein-cholesterol, and triglyceride levels.

RESULTS:

A total of 37 participants were randomized; 32 participated in the intervention (EXE n = 13; NoEXE n = 19). At baseline, 43.8% of participants were sarcopenic and 40.6% met the criteria for MetS. Post-intervention, EXE significantly improved lean mass (d = 0.9), sarcopenia prevalence (d = 0.8), body fat % (d = 1.1), strength (d = 0.8-3.0), and prostate cancer-specific quality of life (d = 0.9) compared to NoEXE (p < 0.05). No significant differences were observed between groups for physical function or MetS-related variables except waist circumference (d = 0.8).

CONCLUSIONS:

A 12-week resistance training intervention effectively improved sarcopenia, body fat %, strength and quality of life in hypogonadal prostate cancer patients, but did not change MetS or physical function. PRO did not offer additional benefit in improving body composition.

TRIAL REGISTRATION:

ClinicalTrials.gov: NCT01909440 . Registered 24 July 2013.

KEYWORDS:

Body fat; Metabolic syndrome; Muscle mass; Prostate cancer; Protein supplementation; Sarcopenia; Strength training; Survivorship

PMID: 29614993 DOI: 10.1186/s12885-018-4306-9

[vputin]

Thanks for the well-documented and acronym-rich post. However, of the five common side effects of ADT -weight gain/muscle loss; hot flashes; memory loss; genital shrinkage; and fatigue, (are these all features of menopause?) it's only the last that concerns me since it can interfere with fitness and thus with our natural immune system.

[MikeDonald]

I am 63, stage 3b when diagnosed in December 2015 with a PSA of 348 and mets to spine and pelvis.

Today was my 380th consecutive work day in the gym, not having missed one since 31 August 2016.

I do a combination of weight training and cardio and am probably fitter, in relative terms, than I was before diagnosis.

My exercise routine and diet may be contributing to my wellbeing - my PSA has been undetectable for over a year, so I'll keep on doing what I'm doing until such time as either I can't or somebody advises me, that for whatever reason, my routines are counterproductive.

[MikeDonald]

Nalakrats. Thanks for your comment.

I look at the posts on here each day and there are some immensely knowledgeable guys on here, including yourself. I am baffled by some of the technical information but trust it's source and intention to educate us all.

The one thing I'm not able to understand or find is your "protocol". I have a completely open mind about complimentary treatments and wonder if you would be kind enough to explain it in simple terms.

Thanks

[Hidden]

Thanks so much for this post. I had given up the fight against Lupron months ago but yesterday I was back to weights and walking! Thanks again.