Oxibendazole inhibits prostate cancer cell growth.

[pjoshea13]

New study below.

Oxibendazole is yet another existing drug that may be repurposed against PCa.

"Oxibendazole is a benzimidazole drug that is used to protect against roundworms, strongyles, threadworms, pinworms and lungworm infestations in horses and some domestic pets." [2]

Speak with your vet. LOL

"The mean size of 22Rv1 tumors in nude mice treated with OBZ (25 mg/kg/day) was 47.96% smaller than that of the control mice."

-Patrick

[1] spandidos-publications.com/...

Oxibendazole inhibits prostate cancer cell growth

Authors: Qiaoli Chen Yuhua Li Xiaoyu Zhou Runsheng Li

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Published online on: December 11, 2017 doi.org/10.3892/ol.2017.7579

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Abstract

Prostate cancer (PCa) is one of the most common malignancies among men and is the second leading cause of cancer‑associated mortality in the developed world. Androgen deprivation therapy (ADT) is the most common treatment for PCa. However, the majority of androgen‑sensitive PCa patients will eventually develop resistance to ADT and the disease will become androgen‑independent. There is, therefore, an immediate requirement to develop effective therapeutic techniques towards the treatment of recurrent PCa. Oxibendazole (OBZ) is an anthelmintic drug that has also shown promise in the treatment of malignancies. In the present study, the capability of OBZ to repress the growth of PCa cells was assessed in human androgen‑independent PCa 22Rv1 and PC‑3 cell lines. The growth of the 22Rv1 and PC‑3 cell lines, as assessed with a trypan blue exclusion assay, was markedly inhibited by OBZ treatment in vitro, with half‑maximal inhibitory concentration values of 0.25 and 0.64 µM, respectively. The mean size of 22Rv1 tumors in nude mice treated with OBZ (25 mg/kg/day) was 47.96% smaller than that of the control mice. Treatment with OBZ increased the expression of microRNA‑204 (miR‑204), as determined by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR), and the level of p53 as determined with western blotting, two well‑characterized tumor suppressor genes. When miR‑204 expression was knocked down by introduction of an miR‑204 inhibitor, the inhibitory effect of OBZ was markedly reduced; however, when it was overexpressed, the inhibitory efficiency of OBZ was markedly higher, indicating that upregulation of miR‑204 is key for the efficacy of OBZ. Additionally, OBZ was demonstrated with RT‑qPCR to repress the expression of the androgen receptor, and by western blotting to reduce prostate‑specific androgen in 22Rv1 cells. The results suggest that OBZ has potential for clinical use in the treatment of recurrent PCa.

[2] en.wikipedia.org/wiki/Oxibe...

[cesanon]

Oxibendazole is for pets. The researchers are from China.

Without patent protection, no one will fund any FDA compliant clinical trials. Whatever research they do in China, whether inferior or superior to FDA compliance, will never be FDA compliant.

So there would appear to be no good way that we will be able to access Oxibendazole in the US.

[Hidden in reply to cesanon]

Cesanon - My considers me a pet and I'm sure she would force the stuff down my throat if given the opportunity.

[AlanMeyer in reply to cesanon]

I wouldn't be too surprised if you could get someone in China to send it to you.

Alan

[cesanon in reply to AlanMeyer]

You can buy it on Amazon.

But none of us have the skill, experience or education to self medicate or self treat.

Biological systems are way too complicated.

[AlanMeyer in reply to cesanon]

Agreed. Taking this medication would be an act of desperation, only to be considered if everything else has already failed. You have to consider that it could kill you or make you very, very sick. However, desperation can occur.

Alan

[pjoshea13 in reply to AlanMeyer]

Alan,

When you consider how few options there were just a dozen years ago, many would have jumped at it.

For anyone who is desperate, scale the animal dose to your weight & initially use a bare fraction of that dose to assess side effects - & do it under a doctor's supervision, if you can find one who won't run the other way.

-Patrick

[Roland632017]

Hi pjoshea13

What happened? Did you just whipped up something?

I thought I was crazy but now you are finding ways to introduce pet therapy yo humans. Guess who is the crazy one now?

Anyway I try to study your findings it could be the next big thing.

Will be in touch.

[Hidden]

Thanks for this info. It is a hopeful sign that research is ongoing all around the world. No need to disparage this compound just because the researchers are Chinese or that it is a staple of veterinary medicine. Penicillin was developed from some god awful mold on a piece of bread. (PS -- you try spelling veterinary).

[petercraig2]

Indeed "Tapeworm drug fights Prostate Cancer" in Swedish research.

healthcanal.com/cancers/pro...

We need to keep an eye on "Off Label" FDA approved drugs.

Peter