I was first diagnosed in 03 and had surgery. Surgeon told me he got it all and should have no further trouble. PSA started rising 2 years later. I then got Pathology report I got showed he didn't get it all. By then radiation was too late but I took anyhow along with Lupron. PSA rising again two years later. 4+3 Gleason and went back on Eligard 12-15. 3 month shot, severe depression.Choosing intermittent treatment to improve quality of life. Have been off shots since as PSA went down to near 0, but back up to near 100 now. Time for another shot, but seemed the Eligard caused much worse depression than I remember from Lupron. Anyone else have similar effects from Eligard?