I am currently 50. Diagnosed at 42. Prostate removed, chemo, radiation, Casodex about 4 years ago (also made me miserable) Now on Lupron. I am miserable, the hot flashes are borderline painful, gaining weight even though I ride my bike hard in the upper cardio zone 1,000 miles a month. Since my PSA has dropped to .28 my Dr. agreed to go intermittent on the ADT. Not being a Dr I cannot fully understand why we must first become ADT resistant before moving on to other treatments. Does anyone have a DR thinking outside the box?