Statins are sometimes described as being either lipophilic (hydrophobic) or hydrophilic (lipophobic) as though that were a binary condition. While Pravastatin is extremely hydrophilic, fluvastatin is an example of a statin occupying an intermetiate position.
Hydrophilic statins: Pravastatin & Rosuvastatin (Crestor)
Lipophilic: Lovastatin and Simvastatin are the most lipophilic. Atorvastatin & Cerivastatin less so.
I have seen Fluvastatin placed in both categories.
The lipophilic statins tend to increase insulin resistance, which may be a significant issue in PCa, IMO.
"... lipophilic statins diffuse across cellular membranes and exert their metabolic effects in the liver and other tissues; hydrophilic statins require active transport across the cell membrane in order to exert their actions intracellularly. This action of hydrophilic agents is therefore predominantly hepatic and not peripheral" [1]
Lipophilic statins may be required if the intent is to stop cholesterol synthesis within PCa cells.
[1] (2012 - U.K.)
"Bone marrow stroma (BMS) was isolated with ethical approval from consenting patients undergoing surgery for non-malignant disease."
"PC-3 binding, invasion and colony formation within BMS was assessed by standardised in vitro co-culture assays in the presence of different statins."
"Statins act directly on PC-3 cells with atorvastatin, mevastatin, simvastatin (1 μℳ) and rosuvastatin (5 μℳ), but not pravastatin, significantly reducing invasion towards BMS by an average of 66.68% ... and significantly reducing both number ... and size ... of colonies formed within BMS."
"Lipophilic statins and rosuvastatin significantly reduced the number of colonies to a similar degree in clonogenic assays and BMS co-culture (Table 1), with simvastatin being the most potent (reduction of 75.44% and 49.44%, respectively)."
-Patrick