This recent article (Oct 2023) has a nice high level diagram that organizes the more common prostate cancer drugs and their mechanism of action. Scroll down to Figure 1.
De Novo Metastatic Prostate Cancer: Are We Moving toward a Personalized Treatment?
Yes.
This is a fantastic article Skiing! Reading it now. It's me - de novo hi-volume HSPC with metastases to bones! (And so far, due to triplet therapy inspired by the big clinical trials, I'm doing really well. k''h)
Unrelated "Signature P.S." - If one can, everyone with metastatic PCa should exercise a lot! Both aerobic and strength exercise! For QoL and as a likely powerful therapy in-and-of-itself!
Glad you like it. Yeah its me too, except I'm on doublet with apalutamide. I want to get on top this game so I can make good decisions about my treatment when required.
I hope so!
oh well, let’s play (I know it has nothing to do with the original post but…) I raise!
mdpi.com/1422-0067/24/22/16....
Hmm. Article poker.
My article is a summary of where we are for people who are having trouble organizing all the information they are receiving about their current treatment options. Your article is forward looking at where we might get to with gene editing tech.
Both are good.
yes! I am just impatient today and worrying for a future that could even be years from now 😊 I feel like we are so close and yet so far from a solution…
I just hope we can get to a state where all PCa can be treated as a Chronic Condition with low mortality and managed with good treatments.
I think curing cancer is an intractably hard problem where the cure is to be able to kill all PCa cells in their environment(s) (ie all the various locations in our bodies). Cell division and survival is an ancient and resilient process dating back to the dawn of evolutionary history.
All of our current treatment options for advanced cancer are really just playing whack-a-mole, smack it here, watch it popup over there. Learn a little. Try again.
PS
I'm a lot more optimistic than this doom post might seem to suggest.
No no, I agree with you! We are not very close to cure a metastatic cancer (we would need a super gene editing power for that) but I feel we are this close to make it chronic in a way that it does not alter your life expectancy. Kind of what we did with HIV.
Dealer, bring us a fresh deck of cards please.
Good Luck, Good Health and Good Humor.
j-o-h-n Thursday 11/16/2023 10:35 PM EST
Fascinating discussion about the process of PCa metastasis 
Possible repurposing of anti gout drugs for PCa
