Zytiga for high-risk non-metastatic PCa?

[billfenley2]

Hi fellows, My cancer was diagnosed as Gleason 9 and non-metastatic. It's been treated in recent months with EBRT and brachytherapy. I'm on Casodex & Lupron, and the Lupron will continue into 2020. But I feel maybe I could be doing more. Sometimes I'll read on the message boards that someone who seems to be in my situation is taking Zytiga, though Zytiga is associated with metastatic PCa (or in some cases, castration-resistant non-metastatic PCa). I asked my doctor about my taking Zytiga, but it's too non-standard for him. Does anyone have experience with, or information about, taking Zytiga in a case like mine? Thanks a lot.

[Fairwind]

If you use all the bullets now, you may wish you saved some for later...I'm not sure Zytiga is approved for non-met PC. If it's not, your insurance company will never pay for it..What is your PSA now ?

[billfenley2 in reply to Fairwind]

Thanks Fairwind, my doctor's waiting for the 3-month mark after brachytherapy to test my PSA. It hasn't been tested since I began treatment. Your other comments are helpful, thanks.

[Tall_Allen]

It is non-standard to add Zytiga - it might help or it might just add to side effects. In fact, it is questIonable whether ADT is needed at all with brachy boost therapy. Is the Lupron keeping your T levels low?

[billfenley2 in reply to Tall_Allen]

Wow, Allen! Questionable about ADT with brachy boost in the first place! My doctor still hasn't tested me for T, or PSA, and doesn't plan to until 3 months after brachytherapy. Anyway, THANKS as always for writing.

[Break60 in reply to Tall_Allen]

TA

On a related subject , if my T is down to <3.0 on trelstar alone I don’t see any need to go back on bicalutamide and/or avodart or add Zytiga, do you? Psa is declining again after doubling every two months.

Bob

[Tall_Allen in reply to Break60]

Certainly not Avodart, probably not bicalutamide. What does your MO recommend?

[Break60 in reply to Tall_Allen]

I haven’t found one necessary yet.

[billfenley2]

"Standard of care" was the exact phrase used by my doctor. That's interesting and telling about the Batman trial. I do crave the info/knowledge. You've been a source of both here on HealthUnlocked.