Canola oil or Selenium

[BigRich]

Does Canola oil cause PCa cells to grow?

Would selenium in 1 in 8 PCa survivors cause PCa cells to grow?

[wellness]

I don't know if it causes PCa cells to grow, but it is in almost everything today and is about as healthy as motor oil. There is some evidence that selenium can retard cancer growth, so it is part of my nutritional program.

[Daddyishealing in reply to wellness]

Yes selenium can retard cancer growth in many csncers. However when I looked it up for prostate cancer I did run into some research that claimed it made it progress.

[BigRich in reply to Daddyishealing]

You are correct. About 1 in 8 PCa victums could see progression. However, there is no test to see if you are that 1 in 8 person. If you eat food with selenium I don't think that will be a problem; however, supplementation is another story.

Rich

[Hidden]

As far as oils go, I avoid ANY type of vegetable oil, period.

[pjoshea13]

According to the USDA database, canola oil is 9.137% alpha-linolenic acid,

There is nothing good written about alpha-linolenic acid in the PCa literature, & a lot suggestive of harm. For those who think it a healthy omega-3, I can only say: why take a chance?

As I wrote elsewhere, the selenium status of Americans & Canadians is generally good, since the soils of the wheat belts are high in selenium. In contrast, people living in the EC cannot get a sufficiency of selenium.

Studies show that there is no advantage, in the U.S., of being in the 5th quintile of intake, over the second. Just avoiding outright deficiency is enough.

Another study, that looked at a common genetic variation, reported that selenium supplementation might be useful against PCa if one had the first variation, but might promote growth if one had the second.

-Patrick

[back2health in reply to pjoshea13]

Sounds like an interesting report. What is the name of it?

[pjoshea13 in reply to back2health]

LOL! 6 years later it comes back to haunt me!

But take a look at:

ncbi.nlm.nih.gov/pmc/articl...

Best, -Patrick

[BigRich]

Is there a test for this common genetic variation? If so,what is its name.

[pjoshea13 in reply to BigRich]

Rich,

I don't know of a test, but here is some new info (this month) from a follow-on of the SELECT study [1]:

"We noted statistically significant (P < 0.05) interactions between selenium assignment, SNPs in CAT, SOD2, PRDX6, SOD3, and TXNRD2, and high-grade prostate cancer risk."

"Variants in selenium ... genes may influence risk of overall and high-grade prostate cancer, and may modify an individual man's response to ... selenium supplementation with regards to these risks."

"The effect of selenium or vitamin E supplementation on high-grade prostate cancer risk may vary by genotype."

& from May [2]:

"Three hundred and forty-eight patients (48%) had aggressive disease at diagnosis. Two SNPs were associated with cancer aggressiveness at diagnosis ... The odds ratio for aggressive disease in patients carrying TXNRD2 rs1005873-AG/GG genotypes or SELENBP1 rs10788804-AG/AA genotypes was 1.54 ... and 1.45 .., respectively, compared to TXNRD2 rs1005873-AA or SELENBP1 rs10788804-GG carriers. Four SNPs in TXNRD2 (rs1005873, rs13054371, rs3788310, and rs9606174) and the rs230820 in SEPP1 were associated with plasma selenium levels"

"We identified polymorphisms in selenoproteins that may influence the plasma selenium levels and may be associated with the risk of presenting with aggressive PCa in men with localized or locally advanced PCa."

Here is a useful summary of how things stood in 2014: [3].

& here is the 2010 study that made me rethink selenium: [4]

-Patrick

[1] ncbi.nlm.nih.gov/pubmed/271...

[2] ncbi.nlm.nih.gov/pubmed/268...

[3] cancerpreventionresearch.aa...

[4] ncbi.nlm.nih.gov/pubmed/204...

[BigRich in reply to pjoshea13]

Thank you for the information. The above just proves that medicine is still an art, and not a science.

[back2health in reply to BigRich]

Both, Art and Science. The scientific aspect generates the knowledge and understanding.

Applying the knowledge with the highest level of skills is an Art.

Complex disease require both.

[Magnus1964]

I have not read anything that would indicate that canola oil is bad for you. Selenium taken with vitamin E was used in study that found less PCa in those that took the two.

[JoelT]

Vitamin E and Selenium remain an unclear issue in the prostate cancer world due to a lot of conflicting data. The largest study was the SELECT trial which was a randomized, placebo controlled study of over 35,000 men (JAMA, 1/7/09, vol 301, No1) which showed that neither Vit E or selenium offered any prostate cancer prevention advantage together or separately. Some very small older studies (not randomized or placebo controlled) concluded that they did offer an advantage.

Another study followed up the SELECT Trial and at 5.5 years of follow up of the select data concluded that selenium significantly increased the risk of healthy men developing prostate cancer ( JAMA, Oct 12, 20111, vol 306, No 14).

Since this study there have been additional, much smaller studies that seem to be in conflict with each other.

The largest and best studies are the ones I mentioned. My personal conclusion is that there is the risks of pc out weights the possible benefit from supplementation, especially be cause most men eating a western diet get enough of these elements without supplementation.

Joel

[BigRich in reply to JoelT]

" My personal conclusion is that there is the risks of pc out weights the possible benefit from supplementation, especially be cause most men eating a western diet get enough of these elements without supplementation." I agree, with yur conclusion.

[harleymom2000]

Sloan Kettering has a GREAT herbal and vitamin site. Some of the ones I like are fucoidan and olive oil extract. The fucoidan targets PCA cells and the olive oil has alot of cardiac benefits. The site does a good job of covering all bases so check it out. They tell you what research is going on and what the outcomes have been, also list adverse reactions or risks. It is at mskcc.org. Then just put something in the search area.

[BigRich in reply to harleymom2000]

I am aware of the site; however, I must thank you for your reply. It is always a good feeling of seeing people trying to help others.

Rich

[harleymom2000 in reply to BigRich]

Thanks. I use this site religiously because I am trying to lower my mom's blood pressure and keep PCA from becoming an issue for my husband. (small calcifications but no PCA) My dad had PCA and we were able to keep many of his blood levels in check so that when he took docetaxel he never had to do Neulasta (wicked drug). We were making progress and I stay on top of this just in case. Many friends have suffered this horrific disease that goes overlooked by so many because the media has done a terrible job of making people think that folks die of something else first. Not true. My dad died in a car crash instead. Go figure. 68 years old. I favor homeopathy over toxic chemicals but know sometimes that is the only way to kick start the immune system and eradicate disease.

[BigRich]

For your husband, I believe in a yearly PSA test. My then doctor talked me out of having a PSA test one year and the next year, 2 years later, it showed prostate cancer. If I caught it earlier, who knows maybe I could have been cured or not. I feel blessed because I am still a live.

Rich

[marc_andersun]

Sloan Kettering Herbal site is: mskcc.org/cancer-care/diagn...