medicalxpress.com/news/2022...
“…Cancer cells need nutrients to survive and grow. One of the most important nutrient sensing molecules in a cell is called mTORC1. Often called a master regulator of cell growth, it allows cells to sense different nutrients and thereby grow and proliferate. When nutrients are limited, cells dial down nutrient sensing cascade and turn off mTORC1…”
A key thing to note here is what's most important is not what nutrients are available to cancer cells, but rather what nutrient SIGNALING and sensing pathways are upregulated or down regulated by certain interventions.
When it comes to nutrients that cancer can use, our bodies are pantries that are always full. So we cannot "starve" cancer by eliminating nutrients themselves. But perhaps we might starve it by making the pantry door hard to open?
Thank you for the beautiful analogy. What was your reaction to the low protein part? That was the first time I heard such a hypothesis, which led me to post.
Yes, great analogy from noahware. mTOR inhibition has some potential to be beneficial both for cancer and for aging. Much more research needed.but we do know our bodies need adequate protein to maintain health, structure and strength. And the optimal amount appears to be higher after age 60.
We cannot slow down APC growth by restricting protein to low levels. Cancer will just take it from the circulating pool and even break down other tissues to get what it requires, causing wasting (cachexia, sarcopenia). A balanced complete nutrition is essential to support our bodies, even as we live fighting prostate cancer.
so Noah, we need the protein but do something else while we are getting the protein to make it impossible for the cancer cell to use it?? Jim weighs 146 pounds from 210. No mor strength and muscle mass. 100 grams of protein powder every day along with good food seemed like a good idea. What to do, what to do??? Interesting link from no stone, I had to read it twice!
So sounds like Jim may have what MateoBeach is describing above (cachexia, sarcopenia). Whatever diet is pursued, should be under the guidance of one trained in cancer nutrition... but opinions and methods differ among these professionals! I do believe the standard medical approach is more based in tradition (just doing what's always been done) rather than the latest science.
Who knows what the 100 g of protein powder is doing, either for good or for bad? Not many know, but are guessing it will do good. This is based on an oversimplistic understanding of calorie intake and ratios of fat, carb and protein.
The newer science on how diet can be best managed is limited, as are the number of docs who look at this science, but if I was looking to consult such a professional, I might go with someone like Dawn Lemanne or another who is open to different ways to approach diet, beyond the usual "energy-in, energy-out" model:
oregonio.com/about_dr_lemanne/
I trust in Dr. Greger, Dr. Fuhrmann and Dr. Barnard. I try to keep protein at 0.8 g / kg body weight and fat under 30 g / day. I go with a whole food plant based diet avoiding sugar, oil and alcohol. I also follow time restricted eating 18:6 or 16:8, depends on my schedule. I input my daily intake from time to time in CRONOMETER app in order to keep control. With such a diet I need to supplement Calcium, Zinc, Iodine and B12. With my blood tests every three months I also check these values. Doing this since five years and never felt so healthy.
can you give some references to the docs you reccommend? I know of Fuhrman…. I am attracted to 16:8 fasting diet but my wife is discouraging out of fear of body stress affecting my health
Go to amazon.com for books or youtube.com for videos.
That seems like a very good approach... but still a generalized one. Those guys may be good docs, but they are not YOUR docs. So I was referring in this post to consulting a doc who would actually be part of your care team to specifically address details of muscle-wasting and weight loss that may be signs of cancer cachexia. I think cachexia is not well understood, but certainly requires more than "eating right" by the normal standards of a relatively healthy person, vegan or not.
The article concerns colon cancer.
it does indeed, but with such limited amount of data on diet and cancer every little clue helps.
My cancer has morphed to treatment-emergent small-cell neuroendocrine prostate cancer.
Is my cancer castrate resistant?
Small cell prostate cancer
Put another way: Tumor growth can be a byproduct of cancer treatments that kill tumor cells.
Advances in the Treatment of Castrate Resistant Prostate Cancer
