New Italian study [1] below.
It's known that men who become diabetic have less PCa risk. Considering that diabetics have a higher risk of every other form of cancer, it seems to me more logical to say that:
... an untreated pre-diabetic condition is common in older men & increases the risk for PCa.
The metabolic syndrome, although it might never progress to diabetes, is a pre-diabetic condition.
[2] "About 34 percent of adult Americans are estimated to have it. Risk of developing metabolic syndrome increases as we age."
"Metabolic syndrome is a group of risk factors that raises risk of heart disease, diabetes, stroke, and other health problems. It is diagnosed when any three of the following ve risk factors are present:
• High blood glucose (sugar)
• Low levels of HDL (“good”) cholesterol in the blood
• High levels of triglycerides in the blood
• Large waist circumference or “apple-shaped” body
• High blood pressure
Metabolic syndrome is a serious health condition.
"
My opinion is that the triglycerides:HDL ratio is most directly related to PCa risk. It is a measure of insulin resistance.
[3] "According to the American Heart Association, 47 million Americans have {the metabolic syndrome}."
[4] "50 percent of those 60 years of age or older were estimated to have the metabolic syndrome in 2011-2012"
In other words, we have a better than even chance of having MetS as we enter the PCa years.
In the new study [1]:
"Median age and preoperative PSA levels were 66 years ... and 7 ng/ml ..., respectively."
"Median BMI was 26.12 kg/m2 ... with 56 (16%) obese (BMI ≥ 30 kg/m2) patients and 87 (25%) patients with MetS."
"MetS was significantly associated with advanced PCa (45/87, 51% vs 81/262, 31%; ...) and high-grade disease (47/87, 54% vs 98/262, 37%; ...)."
...
How best to reverse MetS?
Crazy for me to attempt an answer, but I would target triglycerides. For some, that will mean increasing the fat:carbohydrate ratio. Dean Ornish type diets increase triglycerides.
For men not on ADT, get a testosterone [T] test. Low T is responsible for some MetS, & it is extraordinarily difficult to reverse MetS with low T.
-Patrick
[1] ncbi.nlm.nih.gov/pubmed/273...
[2] heart.org/idc/groups/heart-...