My mCRPC journey began when I was diagnosed in February, 2007 with a PSA of 8.8 and a Gleason of 9( 4+5 ). With no other evidence of metastic cancer in my body, I elected to have a radical prostectamy using the DeVinchi method and my PSA fell to below 1.0 for about a year. My PSA then began to climb, doubling about every three months. I then elected to have external beam radiation and my PSA again fell to below 1.0 and stayed that way for about a year when it began to climb again, doubling about every three months. Next we tried hormone therapy with Lupron and Casadex and this did not reduce my PSA but it did slow its doubling time.after about two years, my PSA was up to 34.5 and my Urologist recommended Chemothearpy. From my past research, I knew that chemo at that time was not that effective on PC, so I elected to go to MD Anderson and enter a clinical trial in January, 2010. After thorough testing, I was placed in a trial using Aberatone Acitate and Pregnizone and my PSA went from 35.0 to 5.5 in four weeks, from 5.5 to 0.6 in another four weeks and from 0.6 to undetectable in another four weeks. My PSA has remained undetectable for the last five years and all the tumors visible when I started at MDA have disappeared or are barely visible today. Aberaterone Acitate was approved by the FDA about three years ago and is now sold under the trade name Zytiga.