My son has been on Vyvanse (very low dose) for the past 8 years with little issues. He had a serious meltdown today. He is depressed, says the meds, while the help, make him feel "high" and he hates it. It also makes him angry and hopeless where it hasn't before. My son isn't on any other drugs, doesn't drink and only takes the meds through the week. I'm going to the Dr. with him tomorrow to discuss alternatives. I'd love to know if anyone else has experienced this. We still have college to get through!