I was diagnosed with WG late January 2013 confirmed with kidney biopsy. Because it was caught so early, I was prescribed Methotrexate (beginning at 10 mg and increasing to 30mg by April) and Prednisolone (beginning at 50mg and decreasing to 30mg by April). When I was diagnosed I immediately bought the testing strips so that I could test my urine daily as the renal specialist emphasised that over the 3 months there should be a reduction in the amount of blood leaking from kidneys. This did happen and two weeks ago the strips showed negative traces. At the same time I got a call from the rheumatologist and renal specialist because of concern about the latest blood tests which showed problems with the liver and both specialists suspected it was the Methotrexate. I was told to stop taking it immediately but continue with Pred, until my next appointment in 2 weeks time when the specialist would examine the results from another blood test. The breathlessness I was experiencing subsided and I generally began to feel much more energetic after not taking Methotrexate for 2 weeks. However, I continued testing my urine and today the testing strip indicated high levels of blood again. Is 2 weeks without something like Methotrexate going to put me right back to where I started 3 months ago or is there 'a period of grace' when changing drugs. Or is it possible to have the occasional 'blood leak'? I am predicting that the specialist will put me on Azathioprine or maybe something stronger. Any advice would be greatly appreciated.