MELODY Study, Imperial College - Covid 19 in-home antibody testing research study

[May7]

I received a letter last month (February) from Imperial College/NHS for the MELODY Study saying,

"We have chosen your name at random from a list of people who may either have a rare autoimmune disease or type of blood cancer which is usually treated with immunosuppressive treatment held by the National Disease Registration Service".

I volunteered of course, and have received the kit and done the test.

I'm pleased to say that my test showed Positive results for the longer lasting IgG antibodies. Although this test is not 100% accurate at an individual level, I feel that it is an encouraging indicator.

I was also pleased to be able to contribute to the questionnaire about life and covid fears, plus effects on my mental health.

Has anybody else here been approached and done the test?

[Nadine99]

From reading on the FB site, many Vasculitis people have received this. We've just done my husband's today.

[AmyS1]

I have done the study and was very disappointed after 4 vaccines no antibodies!! I had previously had antibodies it is only 8 weeks after my last vaccine! On Infliximab metoject and steroids.

[May7 in reply to AmyS1]

I'm sorry to hear that. Hopefully it's true what they say that it isn't necessarily so. I just checked and my last jab was 7 weeks ago, so hope it keeps up! I am on 5mg Preds and 1000mg mycophenolate per day as maintenance.

[2534]

Yes I have the kit and will test today. I had a private test so it will be interesting to compare although I guess you don’t get an actual figure for antibodies. The one done already was 53 micro grams /

[2534]

I too have Vasculitis

[May7]

I think I should have mentioned that I had my 4th Jab 7 weeks before this test. Also, that I have been on 5mg Prednisolone with 1000mg Mycophenolate per day for my EGPA.

[NYinLON]

I did my test yesterday, and like you, was pleased that my result came back positive for 'G' antibodies. I have MPA and had my 4th jab in late January.

[EbonyWillow]

I’ve just done the test and have positive IgG only. I have EGPA, on Rituximab, last infusion 22 December 2021, have had three Pfizer vaccinations, last one 15 November 2021.

[May7 in reply to EbonyWillow]

That is very encouraging, being on Rutuximab and having had your last jab a couple of months before me. I'll be most interested in seeing the collated research results and statistics regarding people's different circumstances.

[Mooka]

I did my test a couple of weeks ago. I know I have some antibodies as I’ve being doing the ONS survey. I was really pleased to see this break down to IgG and IgM and was pleased to see a faint line in the igM as my immunoglobulin levels have been wiped out by rituximab. I’ve had four vaccines but it has been suggested to me that I may get antibodies from the immunoglobulin replacement therapy. I hope this study brings the answers we all need.

[DevonLottie in reply to Mooka]

Mooka. I receive igG replacement (privigen) but had a clear line indicating igG antibodies for covid. Of course this test isn't 100% accurate but suggests even with replacement therapy there's hope for us!

[DevonLottie]

Yes I did this yesterday and I too have igG antibodies. Very reassuring news.

[gibson100]

Yes.Tested positive but potentially inconclusive apparently

[AndrewT]

Dear May 7,

I am part of this 'Program', amoungst some others too. One of the reasons I was given a Third, then Booter, jab was, I'm sure in part anyway, because I proved to have 'NO' antibodies- after the first two Jabs.

I haven't had a Follow Up, for a While now, so maybe I will Contact them.... in case I have been 'forgotten'- well you never know! (unlikely as 'They' have been so On The Ball, regarding the Vaccines.)

I think this Study is associated with the University Of Oxford, if memory serves???? I am also Enrolled with Addenbrooke's Hospital and Ipswich Hospital- where my Consultant is- and maybe even with The University College Hospital London, where I was first Treated, though this is now 'highly unlikely' by now.....

I was asked to Take Part, in a "Study Of How Vitamin 'C' Affects the Vascular System" many years ago now, I was even 'Promised' a copy of the Results- I never got it though. (Oh well I hope the Research Helped 'Others'.)

So, to answer your question May7, yes I am- even if I can't be Too Sure if I'm currently 'On The Books', so to speak.

I am personally ALWAYS happy to Take Part, in Research, especially after 'everything' the Medical Profession has 'Done' for me (Saving My Life and all that!).

AndrewT

[May7 in reply to AndrewT]

The research study that I tested for is by Imperial College, and associated with Cambridge, Sheffield and Nottingham universities. I hope you have been part of this as well, and well done for all you do.

[AndrewT in reply to May7]

This Sounds like the Addenbrooke's Study, so yes this too!

[2534]

Yes, I completed the Melody test and found I was negative. In common with others here it seems that the culprit is Rituximab. I had no idea it was such a heavy suppressant'

[lismacb]

Hi. Also took the Melody Study test and unfortunately no response whatsoever. Negative on both and also on Rituximab. Disappointed after 4 jabs.