I don't know if anyone knows but if we are producing lots of t3 via the peripheral tissues because of a low t4 is this the same 'quality' as the t3 that would have been produced from a normal amount of t4?
I ask because of my hpo symptoms and because I read that,
'However, serum T3 measurement, whether total or free, has limited utility in hypothyroidism because levels are often normal due to hyperstimulation of the remaining functioning thyroid tissue by elevated TSH and to up-regulation of type 2 iodothyronine deiodinase (75)’.
I don't really understand this? It says this type of t3 has limited use - so could this account for hypo symptoms despite high levels of t3 being available?
It implies that the t3 produced from overstimulation is somehow different from the t3 produced by usual conversion methods.
Can anyone help?