Can anyone please point me towards any research relating to interactions with estrogen and levothyroxin, especially absorbtion. I have trawled the web but have found very little. I am on evorell hrt and 50 mcg levo, reduced to this dose as my bloods are too high for the 75mcg I was orginally on. However, after 10 days on the reduction, my hands and feet are freezing and I have got ill (not had a virus for about a year - coincidence?). I am particulary interested with thyroid binding globulin, which I have read is in the estrogen and ensures that the thryoxin goes into the blood but does not get the vital organs. I would very much like to get some solid and recent research to give to my doctor, in the hope that I can get my much needed additional 25mcg back, or change to a treatment which works with my hrt. All information gladly received. Many thanks.