I was grateful for levothyroxine when first diagnosed with hypo (3 years ago), but from the fourth month new symptoms began and gradually over 17 months I had difficulty in walking/standing/bending (stiffness/joint and muscle pain), which resolved when I changed to another generic T4. From the 8th month, I also began to have a frequent racing heart, eventually leading to sinus tachycardia (pulse over 105 p.m.).- I took betablockers. I was always feeling quite ill.
I asked the GP and the endocrinologist if I could try a brand T4 instead of the generic but wasn't allowed.
Earlier this year, it was agreed that I could trial T3 added to a reduced generic T4 with the proviso that my levels remained within range. .Within 36 hours my whole system calmed down and I hadn't felt so good in a long, long time and did not need to take betablockers.
I had a "honeymoon period" of about six weeks, : No tachycardia: No startling awake due to heart leaping: No insomnia or broken sleep: No horrible sensations in my stomach: No night sweats: No betablockers: Not feeling so very, very ill. Tongue doesn't feel so swollen. Frequent neck pain gone.
Then began the usual palpitations/tachycardia with the ferocity I had had previously with the use of sole generic T4. I had chest pain, sore heart and frequent stabbing : pains. I had high pulse rates but the highest I recorded pulse was 144 p.m. on my monitor (I took a photo) and had to take the betablockers again.
I had another ECG for the chest pain and it was normal.
I know T4 stays in your system for about 7 days (and also because I was taking T3) I decided not to take T4 for seven days to see if it made any difference and lo and behold I began to feel better. So much so I did not take T4 for a number of weeks during which time experienced a feeling of 100% NORMAL GOOD health. I added the generic T4 again as I wanted all my levels to remain within normal range when I next had a blood test and not have T3 discontinued
However, by chance the pharmacist gave me a branded T4 and I am now on the second month with this new combination of branded T4 and T3 and have had: only 4 betablockers in the month (instead of 2 daily (60 tablets) for Palpitations .
I hope this continues.
I do not want generic T4 again .
I only found out about fillers/binders through Thyroid UK thyroiduk.org.uk/tuk/pages/...
I have seen a neurologist, cardiologists, dermatologist (for hair loss) and had umpteen other things excluded.
I saw the Thyroid Nurse yesterday who was pleased with my blood results and she will consult with the endocrinologist who made a humane decision to allow a trial of T3 with T4 for which I and my family are very grateful.
I have asked if I can continue with this regime of using branded meds, I await a reply..
It is no wonder people feel some animosity against BTA and the Royal College of Physicians for their insistence that Levothyroxine only is to be prescribed and tying GP's hands, so that you (the patient) and the GP cannot work together for a possible solution and they also state (should T3 be added) if symptoms persist it is due to outside influences such home/work. What a cheek.
PS - I also found this very informative thyroiduk.org.uk/tuk/pages/...
I am feeling very well indeed. and hope it continues..
EDIT : 21ST OCTOBER
Here is Wiki link explaining the term 'generic drug' en.wikipedia.org/wiki/Gener...
EDIT 22ND OCTOBER
Here is another link thyroid.about.com/cs/drugda...