peroxidase antibody

Can anyone advise - recent test results thyroid peroxidase antibody 191, antigastric parietal cell ab +++

(no number just plus) Lh 25.3 FSH90.4 - no reference ranges given - can anyone give me an idea what range peroxidase is - ive been hypothyroid since 1990 and did not have antibodies then but past 18months been acutely unwell - felt both hypo and ? hyper but always with exhaustion Terri

2 Replies

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  • Terri,

    I managed to find the following information about the LH, FSH and TPOab tests and reference ranges. Be aware that reference ranges can and do vary. Small variations occur due to the test technology and manufacturer, how the range was established, and due to the use of different units. (Seems to me that the UK is usually fairly consistent in units used.)

    The site does have details of many, many tests and could be very useful.

    Luteinising hormone (LH)

    NB Not recommended for the routine diagnosis of the menopause

    follicular: 2.4 - 13 IU/L

    ovulatory: 14 - 96 IU/L

    luteal 1-11 IU/L

    post menopause: 7.7 - 59 IU/L

    male: 1.7 - 8.6 IU/L

    pathology.bsuh.nhs.uk/patho...

    Follicle stimulating hormone (FSH)

    NB Not recommended for routine diagnosis of menopause

    follicular: 3.5 - 13 IU/L

    ovulatory: 4.7 - 22 IU/L

    luteal: 1.7 - 7.7 IU/L

    post menopause: 26 - 135 IU/L

    males: 1.5 - 12 IU/L

    pathology.bsuh.nhs.uk/Patho...

    Thyroid peroxidase (TPO) antibody (TPO, anti TPO, anti thyroid peroxidase, anitthyroid antibodies)

    Routine thyroid autoantibody test to help predict clinical hypothyroidism, usually in patients with increased TSH.

    TPO antibodies at high titre are found in patients with Hashimoto's thyroiditis (95%), primary myxoedema (90%) and Graves disease (18%). Low titre TPO antibodies may occur in goitre, thyroid carcinoma and in other organ-specific autoimmune diseases e.g. PA. Antibodies may be predictive of future thyroid disease so clinical and biochemical follow up is advised.

    <35 U/mL

    pathology.bsuh.nhs.uk/patho...

    For the antigastric parietal cell ab the site has this:

    Gastric parietal cell (GPC) antibody

    These are present in individuals with autoimmune gastritis and pernicious anaemia. However they are not specific for these conditions, as they may be also found in healthy individuals, particularly with increased age, and in those with other autoimmune conditions (thyroiditis, Addison’s Disease, IDDM). If Vitamin B12 levels are low then intrinsic factor (IF) antibody should be requested in addition to gastric parietal cell antibodies. These will be sent to an external laboratory. GPC antibody is more sensitive but less specific for pernicious anaemia than IFantibody.

    pathology.bsuh.nhs.uk/Patho...

    All the best

    Rod

  • Hi Rod and thank you for this info- was seen by consultant endo

    once and discharged there will be no follow up and I have been told by gp

    that anti gastric parietal cells confirm Pa - although I now know this is not definate. Terri

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