High Methylmalonic Acid level: hi I have... - Thyroid UK

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High Methylmalonic Acid level

ChloeEllen profile image
6 Replies

hi I have Hashimotos and I am currently pregnant.

I had my bloods done at my first midwife appointment and my b12 came back low.

the lab must have done further testing because another test came back called Methylmalonic Acid and the level shows at 677 which is very high? - does anyone know what this means and is it normal in pregnancy?

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ChloeEllen profile image
ChloeEllen
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SlowDragon profile image
SlowDragonAmbassador

congratulations on your pregnancy

Did you get FULL Thyroid and vitamin testing as detailed in previous post 6 months ago

Exactly what vitamin supplements are you taking

Pregnancy guidelines

thyroiduk.org/having-a-baby/

NICE guidelines that if hypothyroid or subclinical you should see endocrinologist BEFORE TTC

cks.nice.org.uk/topics/hypo...

See pages 7&8

btf-thyroid.org/Handlers/Do...

Also here - dose increase in levothyroxine as soon as pregnancy test confirms conception

cuh.nhs.uk/patient-informat...

thyroidpharmacist.com/artic...

Low ferritin, low thyroid levels and miscarriage

preventmiscarriage.com/iron...

Low iron and hypothyroid

endocrineweb.com/news/thyro...

Folate and B12 and Neural tube defects and autism

healthunlocked.com/thyroidu...

B vitamins are Goldilocks vitamins when pregnant, you don’t want to be supplementing too much or too little

helvella profile image
helvellaAdministrator

High methylmalonic acid often means inadequate B12.

Methylmalonic Acid

Also Known As

MMA

labtestsonline.org.uk/tests...

It is not normal in any circumstances.

My personal take is that if it has already been determined that your B12 is low, you should have immediately been started on treatment. The question being whether that should be an injection or oral. And, also test for Intrinsic Factor antibodies (though that test often produces false negatives).

It is important to know why your B12 is low.

Maybe look here:

healthunlocked.com/pasoc

CarnivoreQueen profile image
CarnivoreQueen

Hi ChloeEllen. Congrats on your pregnancy! Sometimes the Methylmalonic Acid is added to verify B12. High Methylmalonic Acid reveals a true B12 deficiency. My B12 isn't low, but is lower than optimal. I just got a bottle of sublingual B-complex drops to raise my levels.

stopthethyroidmadness.com/l...

SlowDragon profile image
SlowDragonAmbassador

How low was B12

They should also have tested folate and ferritin

Any obvious reason for low B12

Are you vegetarian or vegan

Or are thyroid levels not very good

What are your current TSH, Ft4 and Ft3

Katherine1234 profile image
Katherine1234

Mine was as high as that, it means low B12. I also had enlarged red blood cells. I have to be on B12 injections. It is not good to be that high. Mine is now just scraping in at an 8 which is top of ok range.

bookish profile image
bookish

Hi, no it is not normal and you should be given B12 injections frequently at least until MMA comes down, then regularly. The pregnancy may add to the high MMA, but in combination with low serum B12, you are deficient and the B12 needs treating. You do not want to be breastfeeding with a B12 deficiency. Best wishes

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