Your thoughts on this will be appreciated, please

[RedApple]

This post is being created on behalf of someone who is unable to post for herself at this time.

I may not be able to give answers to specific questions quickly, but your opinions will be appreciated and passed on.😊

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41 year old female, has been ill for a long time with long covid and reaction to vaccine.

Previously put on B12 injections, iron, D, probiotics etc which has helped a bit.

Two years ago, did a Medichecks full thyroid test and all was fine. (I don't know what those results were, so as we know, 'fine' may not be applicable in our expereince!)

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However, a recent thyroid test showed:

Free Tri-iodothyronine (FT3)

Normal range: 2.4 - 6.0 pmol/L RESULT 5.9

Free Thyroxine (FT4)

Normal range: 9.0 - 19.1 pmol/L RESULT 14

Thyroid Stimulating Hormone (TSH)

Normal range: 0.35 - 4.94 mIU/L RESULT 0.1

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Now on Carbimazole

Am awaiting the following info which I'll add as soon as I can:

Dose of carbimazole currently taking, whether the test above was done before or after being on carbimazole, and time of day test was done. Current symptoms.

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(NB Anti-vax comments will be removed as per forum policy)

[Buddy195 Administrator]

Do you have test results for thyroid antibodies?

[PurpleNails Administrator]

If Graves is suspected it must be confirmed with positive

TRab TSH receptor antibodies - (measures stimulating, neural & blocking antibodies) & or

TSI (Thyroid-Stimulating Immunoglobulin)

(TRab & TSI are biomarkers for Graves)

TPOab (Thyroid Peroxidase antibodies) & TGab (Thyroglobulin antibodies)

Should ALSO be tested (but are not unique to Graves)

*IF* this was a diagnostic blood test - before carbimazole. I’m my opinion - it was too soon to commence carbimazole as frees are not above range. Graves typically have levels over 2x normal range BUT it’s not how over range FT4 & FT3 are - it’s if the over active levels are transient or likely to continue.

If test is since starting carbimazole it usual to reassess & adjust dose by 6 weeks. Therefore likely needs a reduction.

Carbimazole & blood test timings are not as critical as when replacement taken.

It lowers immediate production for a period of time but the effect on FT4 & FT3 levels is much more gradual.

[DippyDame]

On what basis was Carbim initiated?

I'm questioning hyperthyroidism!!

These results don't seem to provide that answer....FT3 may be almost top of range... but not excessively over

Would FT4 not also be higher if hyperthyroid

I think we'd need more info re medication and doses taken.

As you infer "fine"is not a diagnosis!

Her FT4 is low at 45.50% thro the ref range....yet FT3 is sitting at 97.22%

I have read that (some)patients with covid have lower FT4 and TSH

Research indicates that amongst other issues thyroid dysfunction, including changes in thyroid gland function, thyroiditis, and autoimmune thyroid disease can result from Covid

Could this high FT3 be the consequence of changes in thyroid gland function, with the result that the thyroid gland has started to pump out extra T3 to allow the body to function..... while the thyroid is failing

We don't know her dose(s) or symptoms but I wonder how her current medication is affecting these results

Sorry Red Apple...mind like a grasshopper....such as they are I offer my thoughts.

[greygoose in reply to DippyDame]

They were my thoughts, too. I cannot see any justification for carbi in those results.

[DippyDame in reply to greygoose]

That's a relief....thank you greygoose !

[RedApple Administrator]

DippyDame greygoose Still waiting for more info but we think the test results quoted are whilst taking carbimazole.

[greygoose in reply to RedApple]

OK, so not much to go on then, really.

[DippyDame in reply to RedApple]

Hopefully more info will help ....including symptoms.

[Wua13262348]

Possible Central Hypothyroidism and DIO 1 mutation????????Mutation causing higher FT3 % to FT4 %????????? Possible poor signalling mutations lots of the forum members have including me??? Blue Horizon Thyroid Genetic Tendency test would exclude or include these possibilities????