Is there a study using 100mcg of T3?

[silvike]

Hello everyone. Is there a study in which a group treated with t3 monotherapy receives at least 100mcg of liothyronine? I want to convince my doctor to increase my dose, and I noticed that he is only interested in studies. He thinks that even 60 mcg was a super high dose and he hardly wanted to give 80 when I asked for an increase. Now I would like to ask for another increase and somehow convince them that this is not an abnormal, dangerous dose at all.

[DippyDame]

T3 is only "dangerous" if the dose is more the body needs!

We need to understand what our body needs....and why.

A few of of us do need a high dose.

Are you in the UK?

I'm surprised a GP prescribed 80mcg.

Increasing from 80mcg to 100mcg is a huge step... we normally titrate in 5mcg steps to avoid missing the sweet spot

I doubt you will be prescribed 100mcg.....though that doesn't necessarily mean you don't need it

100mcg is described as as supraphysiological dose of T3....and it freaks most medics out!

You have just arrived here and have given no details of symptoms, diagnosis or treatment. To help us help you we need those details. It would help if you complete your bio please.

i've never seen a study specifically re 100mcg T3 but I've appended links to various studies thay may be of interest.

Good luck.

pubmed.ncbi.nlm.nih.gov/269...

Liothyronine use in a 17 year observational population-based study - the tears study

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healthrising.org/blog/2019/...

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thyroidpatients.ca/2019/01/...

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paulrobinsonthyroid.com/dr-...

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thyroidpatients.ca/2021/01/...

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thyroidpatients.ca/2018/07/...

[silvike]

Thank you very much for your help, I got my dose increased. 🙂 I found an article on the recommended site thyroidpatient.ca:

thyroidpatients.ca/2019/09/...

This one refers to the two studies, SELENKOW & ROSE, 1976 and CHOPRA ET AL, 1973 . The doctor was very interested and appreciated the new information. I always increase my dose very slowly, 5mcg every two weeks.

[pennyannie in reply to silvike]

Is your doctor treating you on the NHS ?

[silvike in reply to pennyannie]

I'm not in the UK, I live in Hungary.

[helvella Administrator]

In the UK, the Patient Information Leaflets say as below (same for all makes):

Adults:

The dose will depend upon your

condition, ranging from 10 micrograms

to 60 micrograms daily in divided doses.

mhraproducts4853.blob.core....

(I suspect the same will be true in several European countries.)

In the USA, the equivalent of Patient Information Leaflets say as below (same for all makes, I think):

Adults

The recommended starting dosage is 25 mcg orally once daily. Increase the dose by 25 mcg daily every 1 or 2 weeks, if needed. The usual maintenance dose is 25 mcg to 75 mcg once daily.

dailymed.nlm.nih.gov/dailym...

That is:

The UK’s 60 is arbitrary - it is three tablets.

The USA’s 75 is arbitrary - it is three tablets.

What I am trying to say is this, it is understandable that your doctor, seeing the information as in the UK, would think 60 was the top dose.

And another doctor who just happened to work in the USA, would think 75 is the top dose.

But the wording in the USA version includes the word “usual”. It doesn’t say that more is never going to be needed! And the UK version is lame and really gives no basis for anything.

100 is only 33% more than 75!

This paper looks relevant:

Front Endocrinol (Lausanne). 2020; 11: 432.

Published online 2020 Jul 7. doi.org/10.3389/fendo.2020....

PMCID: PMC7358450

PMID: 32733382

The Differential Diagnosis of Discrepant Thyroid Function Tests: Insistent Pitfalls and Updated Flow-Chart Based on a Long-Standing Experience

Irene Campi,1,2,* Danila Covelli,3 Carla Moran,4 Laura Fugazzola,1,2 Chiara Cacciatore,1 Fabio Orlandi,5 Gabriella Gallone,6 Krishna Chatterjee,4 Paolo Beck-Peccoz,7 and Luca Persani1,7,*

T3 suppression test was performed administering fixed doses of 100 μg of sodium liothyronine divided in three doses of 40 + 20 + 40 μg (every 8 h) given by mouth for 10 days (18). TSH was measured at baseline and 2 h after the last dose of T3. Sixty mg/day of propranolol were given in case of heart rate >110 beats/min. The T3 suppression test was performed in 14, 26, and 70% of controls, RTHβ, and TSHoma, respectively. In most of these cases the TRH test, as described above, was repeated after T3 suppression and TRH was injected 2 h after the last T3 dose.

europepmc.org/article/MED/3...