Is there a study using 100mcg of T3?

[silvike]

Hello everyone. Is there a study in which a group treated with t3 monotherapy receives at least 100mcg of liothyronine? I want to convince my doctor to increase my dose, and I noticed that he is only interested in studies. He thinks that even 60 mcg was a super high dose and he hardly wanted to give 80 when I asked for an increase. Now I would like to ask for another increase and somehow convince them that this is not an abnormal, dangerous dose at all.

[DippyDame]

T3 is only "dangerous" if the dose is more the body needs!

We need to understand what our body needs....and why.

A few of of us do need a high dose.

Are you in the UK?

I'm surprised a GP prescribed 80mcg.

Increasing from 80mcg to 100mcg is a huge step... we normally titrate in 5mcg steps to avoid missing the sweet spot

I doubt you will be prescribed 100mcg.....though that doesn't necessarily mean you don't need it

100mcg is described as as supraphysiological dose of T3....and it freaks most medics out!

You have just arrived here and have given no details of symptoms, diagnosis or treatment. To help us help you we need those details. It would help if you complete your bio please.

i've never seen a study specifically re 100mcg T3 but I've appended links to various studies thay may be of interest.

Good luck.

pubmed.ncbi.nlm.nih.gov/269...

Liothyronine use in a 17 year observational population-based study - the tears study

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healthrising.org/blog/2019/...

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thyroidpatients.ca/2019/01/...

............

paulrobinsonthyroid.com/dr-...

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thyroidpatients.ca/2021/01/...

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thyroidpatients.ca/2018/07/...

[silvike]

Thank you very much for your help, I got my dose increased. 🙂 I found an article on the recommended site thyroidpatient.ca:

thyroidpatients.ca/2019/09/...

This one refers to the two studies, SELENKOW & ROSE, 1976 and CHOPRA ET AL, 1973 . The doctor was very interested and appreciated the new information. I always increase my dose very slowly, 5mcg every two weeks.

[pennyannie in reply to silvike]

Is your doctor treating you on the NHS ?

[silvike in reply to pennyannie]

I'm not in the UK, I live in Hungary.

[helvella]

In the UK, the Patient Information Leaflets say as below (same for all makes):

Adults:

The dose will depend upon your

condition, ranging from 10 micrograms

to 60 micrograms daily in divided doses.

mhraproducts4853.blob.core....

(I suspect the same will be true in several European countries.)

In the USA, the equivalent of Patient Information Leaflets say as below (same for all makes, I think):

Adults

The recommended starting dosage is 25 mcg orally once daily. Increase the dose by 25 mcg daily every 1 or 2 weeks, if needed. The usual maintenance dose is 25 mcg to 75 mcg once daily.

dailymed.nlm.nih.gov/dailym...

That is:

The UK’s 60 is arbitrary - it is three tablets.

The USA’s 75 is arbitrary - it is three tablets.

What I am trying to say is this, it is understandable that your doctor, seeing the information as in the UK, would think 60 was the top dose.

And another doctor who just happened to work in the USA, would think 75 is the top dose.

But the wording in the USA version includes the word “usual”. It doesn’t say that more is never going to be needed! And the UK version is lame and really gives no basis for anything.

100 is only 33% more than 75!

This paper looks relevant:

Front Endocrinol (Lausanne). 2020; 11: 432.

Published online 2020 Jul 7. doi.org/10.3389/fendo.2020....

PMCID: PMC7358450

PMID: 32733382

The Differential Diagnosis of Discrepant Thyroid Function Tests: Insistent Pitfalls and Updated Flow-Chart Based on a Long-Standing Experience

Irene Campi,1,2,* Danila Covelli,3 Carla Moran,4 Laura Fugazzola,1,2 Chiara Cacciatore,1 Fabio Orlandi,5 Gabriella Gallone,6 Krishna Chatterjee,4 Paolo Beck-Peccoz,7 and Luca Persani1,7,*

T3 suppression test was performed administering fixed doses of 100 μg of sodium liothyronine divided in three doses of 40 + 20 + 40 μg (every 8 h) given by mouth for 10 days (18). TSH was measured at baseline and 2 h after the last dose of T3. Sixty mg/day of propranolol were given in case of heart rate >110 beats/min. The T3 suppression test was performed in 14, 26, and 70% of controls, RTHβ, and TSHoma, respectively. In most of these cases the TRH test, as described above, was repeated after T3 suppression and TRH was injected 2 h after the last T3 dose.

europepmc.org/article/MED/3...

[Adamben]

Ton médecin a raison tu vas faire une grosse connerie si tu augmente la dose , moi j'ai eu un malaise cardiaque et j'ai failli mourir en ayant été seulement sous 50mcg de T3 un peu trop longtemps, si tu veux augmenter la dose vas-y , mais dit ou que même si tu te sens pas trop mal , le malaise et peut être même l'arrêt cardiaque vas finir par arriver , c'est pas une question de est ce qu'il arrivera ,la question c'est juste quand , si tu est habitué à la T3 peut être que tu tiendras quelque mois ,mais ton coeur va finir par s'épuiser a force de lui imposer une fréquence de battement trop élevé, et tu vas mourir comme ça bêtement , donc a ta place je prendrais pas ce médoc a la légère, je le pensais léger moi aussi jusqua ce que j'ai fait un malaise cardiaque et failli mourir , je serais mort d'ailleurs si les urgences était pas arrivé a temps

[Kerry124 in reply to Adamben]

Can you translate that to English please?

[Butterfly801 in reply to Kerry124]

He is saying that the OP should follow the doctors’s advice, that T3 will cause a heart attack and that he (Adamben) is alive only because he ended up in hospital in time. He is saying T3 causes the heart to eventually give up and that the OP will die, and that the question is not if it will happen but when. He is saying he himself ignored his doctor and paid the price by having a nearly fatal heart attack on 50 mcg of T3.

[Kerry124 in reply to Butterfly801]

Ok. I am not medically trained but I had a thyroid storm because of having very high T3 I did not have a heart attack but my heart was beating very fast and I was shaking and sweating so T3 doesn’t always cause a heart attack. This was in 2019 and I have been ok since then. So what I am saying is this is not aiways the case. I hope he is alright now

[Butterfly801 in reply to Kerry124]

Are you still taking T3?

[Kerry124 in reply to Butterfly801]

I have taken Thyroid S in the past to support my thyroid but never T3. I have Graves’ disease which sometimes can make you hypothyroid. It’s hard to explain but at the moment I am in remission so I am taking nothing except Vitamin D and Folate