Who takes high T3/ T4/NDT dosages?

[charley123]

I take 200 T3 and still hypo. My doctor said i should increase to 260 T3.

Who takes also a high dosage?

[greygoose]

You most certainly should not! 205 mcg at the most - only ever increase by 5 mcg - or less - at a time.

I was on 225 mcg for a brief period but I don't need that much anymore. Now I'm on 75 mcg.

When I took NDT, I was on six grains before I decided it just wasn't for me.

Not levo I got up to 200 mcg, then 200 mcg levo + 40 mcg T3...

It's all in my profile if you're interested.

[charley123 in reply to greygoose]

Greygoose did you have tachycardia when you were hypo?

I was on 75 t3 for years and after 2,5 years became the hypo symptoms. I tried NDT(3,3.5 and 7 grain), T4 (150-200) and now back again on T3. My problem is that i get improvement in some symptoms when I increase and then worsening...On every dosage on every medication...My thyroid shrunk from 12 ml to 4 ml within 5 years without antibodys..

[joydot in reply to charley123]

I developed heart issues.

[greygoose in reply to charley123]

No, I don't think I did get tachycardia. Although the specialist my endo sent me to - just in case! - told me that one can have it without having symptoms. But I took that with a huge pinch of salt!

But, you most certainly can have autoimmune thyroiditis without ever having over-range antibodies. And if your thyroid has shrunk, it sounds like you have Ord's. Which antibodies have you had tested?

[charley123 in reply to greygoose]

What is Ord's? I tested 2 antibodies. TPO and the other.

[greygoose in reply to charley123]

Ord's is Hashi's without the goitre, where the thyroid shrinks up to a tiny pea. Same antibodies, though: TPO and Tg. Was it Tg antibodies the other one?

[charley123 in reply to greygoose]

2016TPO-AK 37 U/ml < 60

Tg-AK 17U/ml < 60

When you was on 225 T3 how often you splitted the dosage?

[greygoose in reply to charley123]

I didn't split it. I took it all in one go before bed. If you need a dose that high then splitting it would be counter-productive because you need the high dose to saturate the receptors in order to get some of the T3 into the cells.

[charley123 in reply to greygoose]

I take 80/60/60. The doc said i can take it 2 times. My other doc said i should take 5-6 a daiy 🤔

[greygoose in reply to charley123]

5-6 what a day? 5-6 doses? When would you eat???

Have you ever tried taking it all in one go?

[charley123 in reply to greygoose]

No i never tried but i want try it. How would you recommend me to start?

[greygoose in reply to charley123]

I'm afraid I can't tell you that because I've always taken it in one go, starting low and building up slowly. You could try starting by cutting out the middle dose and taking 110/90 for a couple of weeks, see how that goes.

[charley123 in reply to greygoose]

Yes thats great. But i dont know when i should take the second one? When getting up and then 12 hours later?

[greygoose in reply to charley123]

There's no time you 'should' take it, it's when it suits you best. And you can only find that out by trial and error. Maybe keep it the same time as usualy to begin with, and see if you feel you need to take it earlier.

[charley123 in reply to greygoose]

Second day on 2x 100t3 every 12 hours.

[greygoose in reply to charley123]

How are you feeling?

[charley123 in reply to greygoose]

Thanks for asking. Like on 3 times. No better no worser.

[greygoose in reply to charley123]

Well, it's encouraging that you don't feel worse!

[charley123 in reply to greygoose]

7 Days after 2 times a day i got depression. I increased from 2x100 to 2x110 but no relief. Could that be from 2x a day?

[greygoose in reply to charley123]

That's far too much of an increase! You should increase by more than 5 mcg at a time. But I doubt taking it twice a day rather than three times would cause depression.

[joydot in reply to greygoose]

6 grains! I thought 3 was high.

[greygoose in reply to joydot]

Yes, 6 grains is probably more than the majority of people take. But, I went onto T3 only and got up to 225 mcg. So, obviously, there wasn't enough T3 in the NDT to make me well. I must have some degree of resistance to thyroid hormone.

[joydot in reply to greygoose]

225 t3? Cornwall endo said it was dangerous to put me above 30! When after 6 months of being sick I doubled it then dropped 10 after most fluid gone he had gp panicking over 50.

2 months Before return t cornwall I was on 50 t3 & went from 250lb to 180. I have a small frame (tall tho). Endo refused to write scrip & gp watched me careen back to 250 in 2months while saying I was “not urgent”.

This is so important yet we’re treated like lunes.

[joydot in reply to joydot]

Btw my normal weight is approx 140-145.. Kate Middleton weighs 135. “medical professionals” didn’t see a problem with me at 250.

[greygoose in reply to joydot]

You have to remember that doctors are terrified of hormones - all hormones - because they don't understand them. They're just not taught about them in med school. And they really don't care about your symptoms, or how you feel, as long as you're on a dose they feel comfortable with.

And, yes, on 250 mcg all my water-weight - over 30 kilos - dropped off. On 75 mcg, most of it is back again, but I can no-longer tolerate more than 75 mcg. That is my dose, because less than that, the anxiety comes flooding back in and I have to raise it again.

[joydot in reply to greygoose]

😵‍💫😭

[charley123 in reply to joydot]

6 Grains are expensive these days.

[joydot in reply to charley123]

True. I’m kinda freaked out by how expensive it’s become. How? Why?

[charley123 in reply to joydot]

You could try T4/T3 combi.

[joydot in reply to charley123]

German doc tried - disaster. Now been on t3 for 18 months with some success, yet becoming clear am having some wierd allergic reaction to it. I can’t take synthetics - ?!?

[charley123 in reply to joydot]

Are you from Germany?

[joydot in reply to charley123]

No. Lived there twice, child & adult. My healthcare was expensive but the nhs makes it seem v worth it.

[charley123 in reply to joydot]

I'm from Germany. But I think that docs are everywhere bad.

[joydot in reply to charley123]

Small world! I had to try 2 diff doctors in Munich as did my daughter, then we had excellent care. Here in cornwall it’s been appalling -

[charley123 in reply to joydot]

PM

[SlowDragon Administrator]

Can you add most recent Ft4 and Ft3 results

Recommended that all thyroid blood tests early morning, ideally just before 9am, only drink water between waking and test and last dose levothyroxine 24 hours before test

This gives highest TSH, lowest FT4 and most consistent results. (Patient to patient tip)

T3 ….day before test split T3 as 2 or 3 smaller doses spread through the day, with last dose approximately 8-12 hours before test

What vitamin supplements are you taking

What are most recent vitamin D, folate, ferritin and B12 results

[Litatamon]

I have never taken t3 only, but have been on very high NDT (could no longer afford the last increase & Thyroid S was problematic at the border on my last order -Canada); high Synthroid & high Synthroid + Cytomel (t3).

Right now I am on 275 mcg Synthroid (prescription is 300 mcg) And I have a prescription for 25 mcg Cytomel.

My highest NDT prescription was just above four grains. (250 - 2× 125 Erfa)

My TSH on a lot of these choices and combinations was as high as 36 (.4 to 4). Highest on both NDT choices. Stayed high on other choices but have it down to between 4 & 5 right now.

The weird thing is I had a pretty darn good panel, my only one at 225 mcg Synthroid but had extreme symptoms, Days were awful & I pushed through for months just to see. Could hardly stay awake. Almost like narcolepsy at times, intense brain fog, issues writing a sentence, hair falling out etc.

Feel the best on NDT (even with a high TSH), but can no longer afford it.

For anyone reading I feel like 50s Synthroid has changed a lot for me (it has markedly less additives). My endocrinologist is good enough to put 6 × 50 on my prescription.

I did not want to be all over the place. Early doctors acting like I wanted cocaine, instead of just needing off Synthroid at the time, budgeting and border issues have caused these meandering choices.

I would really like compounded hormones but it is out of reach for now ($).

I have had tachycardia since my thyroidectomy. On nearly all choices. Didn't matter if my BP was perfect (Synthroid only) or high (every t3 hormone combination). Still over a hundred most days..

[charley123 in reply to Litatamon]

So you still havent found your sweetspot?

[Litatamon in reply to charley123]

Yes that is the short form!

🤣😁💯

[Litatamon in reply to Litatamon]

But since I am financially stuck on Synthroid right now and/or combination I sure am happy to have found 50s Synthroid. I would have realized close to a year ago but when I started the 50s I was on Cytomel too. Cytomel was giving me symptoms & I just assumed it was the Synthroid yet again.