High Thyroglobulin blood results

[Sp19781978]

Hi, I'm new here and looking for some advice on blood results. I have been going to my GP for a couple of years as I just haven't felt well. I've been extremely tired, had weight gain, so cold that my hands and feet turn blue but each time my thyroid has been tested and the results are normal. However after seeing a private GP my bloods came back with following results and I have been referred to an endocrinologist at The Royal Free in London

Thyroglobulin 1326 ( range 0-115)

Thyroid Peroxidase 279 ( range 0-33)

Thyroid Stimulating Hormone 6.18 ( range 0.27-4.20)

Free thyroxine 13.0 (range 12-22)

Liver function test showed high Alkaline Phosphatase. All other results normal although slightly raised cholesterol levels

Anyone had similar?

[SeasideSusie Remembering]

Sp19781978

Both of your thyroid antibody test results are positive which suggests that you have autoimmune thyroid disease aka Hashimoto's which is where the thyroid is attacked and gradually destroyed.

When TSH is over range which yours is, coupled with raised antibodies, then Levo should be started.

Please see article by Dr Toft, past president of the British Thyroid Association and leading endocrinologist, states in Pulse Magazine (the magazine for doctors) in answer to Question 2:

"Question 2 asks:

I often see patients who have an elevated TSH but normal T4. How should I be managing them?

Answer:

The combination of a normal serum T4 and raised serum TSH is known as subclinical hypothyroidism. If measured, serum T3 will also be normal. Repeat thyroid function tests in 2 or 3 months in case the abnormality represents a resolving thyroiditis.

But if it persists then antibodies to thyroid peroxidase should be measured. If these are positive - indicative of underlying autoimmune thyroid disease - the patient should be considered to have the mildest form of hypothyroidism.

In the absence of symptoms, some would simply recommend annual thyroid function tests until serum TSH is over 10mU/l or symptoms such as tiredness and weight gain develop. But a more pragmatic approach is to recognise that the thyroid failure is likely to become worse and try to nip things in the bud rather than risk loss to follow up.

Treatment should be started with levothyroxine in a dose sufficient to restored serum TSH to the lower part of it's reference range. Levothyroxine in a dose of 75-100mcg daily will usually be enough.

You can obtain a copy of the article by emailing Dionne at

[e-mail]

print it and highlight question 2. Have this ready when you see the endo at the Royal Free in case you need it.

Also, because Hashi's often causes low nutrient levels or deficiencies, it would be a good idea to test for

Vit D

B12

Folate

Ferritin

and post results, with reference ranges, on the forum for comments.

[Sp19781978 in reply to SeasideSusie]

Thank you that is most helpful.

[Marz]

Raised cholesterol and liver enzymes so often are raised when Hypo/Hashimotos. When medicated all should be well 🌻

[Sp19781978 in reply to Marz]

Thank you . Maybe they will give me something tomorrow.

[Marz in reply to Sp19781978]

Fingers crossed !

[SilverAvocado]

There are many, very confusing, abbreviations for both of these, but it's more correct to say:

Thyroglobulin antibodies 1326 ( range 0-115)

Thyroid Peroxidase antibodies 279 ( range 0-33)

You have both of these antibodies out of range, which shows you have Hashimoto's auto immune thyroid disease. This means you will probably not have enough thyroid hormone in your body, making you hypothyroid and need thyroid hormone replacement for life.

Sone people get unpleasant symptoms just from having antibodies raised, but many don't.

[Sp19781978 in reply to SilverAvocado]

Thanks for the info. Off to see the endocrinologist tomorrow so maybe they will start me on some medication.

[Marz in reply to Sp19781978]

Let us know how it goes .

[Sp19781978]

Saw the endocrinologist today and have been started on 75mg L thyroxine. I have autoimmune Thyroiditis which is very active. 60% of my thyroid has been destroyed. I also have a 24 hour urine test to do to check for Cortisol and a blood test to check my liver function again as the reading was high. Got to go for another check up in a month too . Thanks for all the reply’s on my original post x

[MichelleHarris in reply to Sp19781978]

Thats great!

I bet your GP didnt do a full Thyroid panel.

You got to see an Endo super quick and he/she has given you a very decent dose to resolve things quickly. Well done.

I was started on 25mcg and titrated up every 3 months only so I was ill for over a year until I got to 125mcg x

[Sp19781978 in reply to MichelleHarris]

Luckily for me I could go private and not have to wait for an NHS appointment. Look forward to seeing if the medication makes a difference! Has the medication helped you? X

[MichelleHarris in reply to Sp19781978]

Yes very much but theLevo has caused thyroiditis. I paid privately too, he was rubbish. Still took 2 wks. If you have a good Endo its great if the name is added to Dionnes list. I hope youre feeling better really soon x

[Sp19781978 in reply to MichelleHarris]

The endo said today that I have Thyroiditis. Maybe I should look that up as not sure what it is! I thought the Levo was to treat it x

[MichelleHarris in reply to Sp19781978]

Yes but sometimes the fillers of the tablets dont agree with a few of us unfortunately x