Extremely high thyroglobulin antibodies

[rrrrramona]

I am new. 62 yr old female. Hashimotos plus goiter.

My thyroglobulin antibodies tested >1000. Thyroid peridase antibodies (TPO) >900. EPV Early antigen D AB (IGG) is 119.

These results are astronomically out of range. Natural Dr. ordered ANA screen, IFA. Result was low level antibody level and all three tiers are negative, indicating the absence of detectable antibodies.

What does this mean? PLEASE HELP

[SlowDragon Administrator]

Are you only just diagnosed?

Or already on Levothyroxine?

If so, how much Levothyroxine are you currently taking?

How do you feel

What are your main symptoms?

Can you add TSH, FT3 and FT4 results and ranges if you have them

For full Thyroid evaluation you need TSH, FT4 and FT3 plus both TPO and TG thyroid antibodies tested. Also EXTREMELY important to test vitamin D, folate, ferritin and B12

Low vitamin levels are extremely common, especially if you have autoimmune thyroid disease (Hashimoto's) diagnosed by raised Thyroid antibodies

Ask GP to test vitamin levels or test privately

Recommended on here that all thyroid blood tests should ideally be done as early as possible in morning and before eating or drinking anything other than water .

If on Levothyroxine.....Last dose of Levothyroxine 24 hours prior to blood test. (taking delayed dose immediately after blood draw).

This gives highest TSH, lowest FT4 and most consistent results. (Patient to patient tip, best not mentioned to GP or phlebotomist)

Your antibodies are high this confirms Hashimoto's, (also known by medics here in UK much more commonly as autoimmune thyroid disease).

Hashimoto's frequently affects the gut and often leads to low stomach acid and then low vitamin levels

Low vitamin levels affect Thyroid hormone

Poor gut function can lead leaky gut (literally holes in gut wall) this can cause food intolerances. Most common by far is gluten. Dairy is second most common.

According to Izabella Wentz the Thyroid Pharmacist approx 5% with Hashimoto's are coeliac, but over 80% find gluten free diet helps, sometimes significantly.

Either due to direct gluten intolerance (no test available) or due to leaky gut and gluten causing molecular mimicry (see Amy Myers link)

Changing to a strictly gluten free diet may help reduce symptoms, help gut heal and slowly lower TPO antibodies

While still eating high gluten diet ask GP for coeliac blood test first or buy test online for under £20, just to rule it out first

Assuming test is negative you can immediately go on strictly gluten free diet




(If test is positive you will need to remain on high gluten diet until endoscopy, maximum 6 weeks wait officially)




Trying gluten free diet for 3-6 months. If no noticeable improvement then reintroduce gluten and see if symptoms get worse

chriskresser.com/the-gluten...

amymyersmd.com/2018/04/3-re...

thyroidpharmacist.com/artic...

scdlifestyle.com/2014/08/th...

drknews.com/changing-your-d...

restartmed.com/hashimotos-g...

[rrrrramona in reply to SlowDragon]

With no thyroid hormone tsh 16.23. Unable to tolerate synthetic thyroid hormone. Can tolerate Naturethroid much better but still suffer from side affects including head tremor, which I did not have prior to treatment. Taking 1 grain to bring tsh into range. free t-3 and reverse t-3 was slightly low before treatment after treatment in range. Tried glutten free for 10 months with no noticable difference.

[rrrrramona in reply to rrrrramona]

What does it mean to have extremely high Thyrogloblin and thyroid peridoxidase antibodies and an ANA showing negative for detectable antibodies?

[vocalEK in reply to rrrrramona]

When you have one autoimmune disease, odds are you might have others. The ANA test was taken so your doctor could rule out lupus. Be glad you don't have that. The very high thyroid antibodies confirm you have Hashimoto's.

[rrrrramona in reply to vocalEK]

Thankyou

[Lora7again]

I have high antibodies ... they are 4000 but doctors have told me they mean nothing even though I know they are giving me symptoms. I think after your thyroid has been attacked they are dumped in your blood stream. I have tried selenium to try and lower them which can work it hasn't done so for me.

[helvella Administrator Thyroid UK in reply to Lora7again]

The antibodies are produced because the thyroglubulin from inside your thyroid spills into your bloodstream when it is attacked by lymphocytes. The antibodies help to clear up that thyroglobulin which should not be in our blood.

The issue of whether antibodies themselves are significant is more subtle. Yes, high antibodies indicate that the thyroid is being damaged and the immune system is on high alert producing them. Hence, you might well feel particualrly poorly when antibodies are high. But do the actual antibodies themselves cause any of that poorly state? Or is it all the other processes?

[rrrrramona in reply to Lora7again]

Thank you, you have helped me understand

[rrrrramona in reply to Lora7again]

Interesting. Thank you for your reply. Glad l found this place.

[SlowDragon Administrator]

Here's a good explanation

hashimotoshealing.com/under...

Have you had vitamin D, folate, ferritin and B12 tested

Good vitamin levels help reduce symptoms

Getting TSH down under one often helps reduce symptoms too

[McPammy]

I have Hashimotos and positive DIO2 gene test from one parent. Meaning I find it difficult to convert T4 to T3.

My sister also has thyroid issues. Hers are different to mine. Her antibodies were in the 1000’s a few years ago. After months of illness and Drs saying not to be concerned about such high antibodies. I don’t wish to alarm you, I wish to help you, she had a fine needle aspiration on a small lump that appeared on her neck. Before this Drs telling her she has no Endocrine issues. The result of the fine needle aspiration was that she had thyroid cancer. The antibodies so high as they were fighting the cancer. Thyroid cancer is a success story as far as a lot of cancers go. She had her thyroid removed within 2 weeks. This was found out by an ear, nose and throat ENT Dr not an Endocrinologist. Maybe you could make an appointment to see an ENT Dr to rule this out at least.

I do not wish to alarm you in any way. I want to help you.

[rrrrramona]

Cancer is my concern. FNA biopsy was ambiguous.

[HashiFedUp]

You have Hashimotos? I’m guessing so if your antibodies are that high. Don’t worry. They can’t treat the high antibodies. It just indicates inflammation.