negative antibodies and Dx Hoshi: Is it unusual... - Thyroid UK

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negative antibodies and Dx Hoshi

Hotdogman profile image
4 Replies

Is it unusual to be diagnosed with Hoshimoto with a negative antibody test?

Clinical dx from Endo in 2019 after multiple TSH results over 4.0. Throughout the last 4 years I’ve

started on Levo and now TSH is @1.70-2.0 consistently every 6 month. Currently on 100mg.

not quite certain if Hoshi or just dealing with Hyptothroidism. Will taking Levo 100 daily surpress thyroid hormone production over time?

I’m scheduling another antibody lab check after 4 years to confirm. All vitamin levels in range.

I never have posted but review chats for info and education.

Thanks,

Mark

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Hotdogman
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greygoose profile image
greygoose

Hi Hotdogman, welcome to the forum. :)

So, how did your endo come to the conclusion that you had Hashi's, then? Did he do an unltrasound of your thyroid? Did you have a goitre? It's not unknown to have Hashi's without high antibody levels - about 20% of all Hashi's cases, I think - but the diagnosis is usually made after an ultrasound.

Anyway, whatever the cause of the hypothyroidism, the treatment is the same, even though how people experience the disease can be different for everyone, regardless of cause - and there are many, many possible causes. There is no treatment for the autoimmuntiy itself.

Will taking Levo 100 daily surpress thyroid hormone production over time?

Yes, it will. Pretty quickly, actually. That's why it's called thyroid hormone replacement. It stops your thyroid working, by reducing the TSH, and then replaces the hormone your thyroid is supposed to be making. But, that's ok. It doesn't kill the thyroid off - the Hashi's will do that. If, for some reason, you stopped taking the levo, the thyroid would wake up and go back to making as much hormone as it was before. Only it wouldn't be enough.

All vitamin levels in range.

Not good enough. 'In-range' is not the same as 'optimal'. Can you give us the actual numbers - results and ranges - and let us have a look. Having optimal nutrients can make such a difference. :)

Hotdogman profile image
Hotdogman in reply to greygoose

Many Thanks for such a quick reply Grey Goose! My PCP sent me for an evaluation to Endo due to a slight enlarge left side on Thyroid. Ultrasound was negative and image was not concerning. Also, no goiters.

She was concerned with slightly higher TSH and some visual signs, (2/3 eye brow, dry skin, and some complaints on energy level and occasionally constipation.) nothing really unusual and no where near some symptoms I read on the board with others.

I requested my vit lab history and will send over highlights when received. I supplement with all the usuals mentioned here, Complex B, B12, D3, Mag, Zinc. Not sure if optimal levels but thats my goal for sure.

I also appreciate the comments on the hormone replacement. I guess im just question a few things going forward and feel I not the classics Hoshi case.

Enjoy the holiday season!

Mark

greygoose profile image
greygoose in reply to Hotdogman

I don't think there is such a thing as a classic Hashi's case. But if there were, it would be thyroid hormone levels wildly swinging between hypo and hyper and back again.

Sounds to me as if you have hypothyroidism due to unknown causes, which many, many people have. Not all cases of hypo are due to Hashi's. So if your antibodies are low, your ultrasound shows nothing abnormal, and your blood test results are abnormal but stable, I cannot see why she would think it's Hashi's.

SlowDragon profile image
SlowDragonAdministrator

Are you in U.K.?

NHS only tests TG antibodies if TPO are positive

Significant minority of Hashimoto’s patients only have high TG antibodies

And 20% of Hashimoto’s patients never have high antibodies

For full Thyroid evaluation you need TSH, FT4 and FT3 tested

Also both TPO and TG thyroid antibodies tested at least once

Very important to test vitamin D, folate, ferritin and B12 at least once year minimum

About 90% of primary hypothyroidism is autoimmune thyroid disease, usually diagnosed by high thyroid antibodies

Autoimmune thyroid disease with goitre is Hashimoto’s

Autoimmune thyroid disease without goitre is Ord’s thyroiditis.

Both are autoimmune and generally called Hashimoto’s.

Low vitamin levels are extremely common when hypothyroid, especially with autoimmune thyroid disease

20% of autoimmune thyroid patients never have high thyroid antibodies and ultrasound scan of thyroid can get diagnosis

In U.K. medics hardly ever refer to autoimmune thyroid disease as Hashimoto’s (or Ord’s thyroiditis)

Recommended that all thyroid blood tests early morning, ideally just before 9am, only drink water between waking and test and last dose levothyroxine 24 hours before test

This gives highest TSH, lowest FT4 and most consistent results. (Patient to patient tip)

On T3 - day before test split T3 as 2 or 3 smaller doses spread through the day with last dose 8-12 hours before test

Private tests are available as NHS currently rarely tests Ft3 or all relevant vitamins

Testing options and includes money off codes for private testing

thyroiduk.org/testing/

Medichecks Thyroid plus antibodies and vitamins

medichecks.com/products/adv...

Blue Horizon Thyroid Premium Gold includes antibodies, cortisol and vitamins

bluehorizonbloodtests.co.uk...

Only do private testing early Monday or Tuesday morning.

Link about thyroid blood tests

thyroiduk.org/testing/thyro...

Link about Hashimoto’s

thyroiduk.org/hypothyroid-b...

Symptoms of hypothyroidism

thyroiduk.org/signs-and-sym...

Tips on how to do DIY finger prick test

See detailed reply by SeasideSusie

healthunlocked.com/thyroidu...

Medichecks and BH also offer private blood draw at clinic near you, or private nurse to your own home…..for an extra fee

20% of Hashimoto's patients never have raised antibodies

healthunlocked.com/thyroidu...

Paul Robson on atrophied thyroid - especially if no TPO antibodies

paulrobinsonthyroid.com/cou...

Gluten intolerance is often a hidden issue too.

You should have coeliac blood test at diagnosis of Hashimoto’s

Request coeliac blood test BEFORE considering trial on strictly gluten free diet

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