Anyone taking Adrenavive who can explain this result?

[Sneedle]

Following my very low Regenerus cortisol results, I've been on Adrenavive 2 for about 4 weeks now, no digestive or other problems.

I've been working upwards and am now on 600mg daily. No perceived change in my symptoms, but I understand it can take several months so I was planning to continue...BUT the random 6am-10am Cortisol sample in my latest blood test shows as high:

620 (166-507 range)

I definitely didn't take Adrenavive the day of the test, I think the last dose would have been about 22 hours before.

Should I reduce? It seems strange to reduce without having had any noticeable benefit. I'm very confused.

Any ideas why this should be? Have I simply reached a good level by only taking Adrenavive for one month?

Thank you.

[TiggerMe]

I'm thinking that serum is total cortisol and saliva is free so comparing apples and pears really 😕 I would be inclined to continue if you aren't having any issues with it... when are you next due to test your fT3/4 as this might give you a clue as to any effect it is having on conversion or uptake 🤗

Edit... just found your other post with results... yes an increase would be good 👍

Looks like the added Adrenavive has help your fT3 get busy and working in your cells rather than hanging around in your blood as your fT3 has halved since your August result.... which is a good thing but you need to top it up now as your body is making better use of it 😏

[Sneedle in reply to TiggerMe]

Eeyore you've saved my bacon!

I didn't think of that - comparing free unbound with the total. It also makes me more confident to continue since the GP didn't comment on it.

There's another thing which might explain it - my daughter (second and last child) left for university about four days before I took the blood test and the empty nest thing hit me. In a very bad way. I have a lot of trauma in my background and basically I fell into my own wound and was in a hell of a state for several days. I found a mention somewhere (NHS Gloucestershire??!!) about trauma causing spikes in cortisol. They were talking about around 1000.

Hang on

Cortisol is a stress related hormone, and as a result very high levels (>1000 nmol/L) can be seen in acutely unwell patients or those in trauma.

gloshospitals.nhs.uk/our-se...

They are talking about being in trauma in the moment, today as it were, but it is well known that traumatic experiences stay in the psyche/body until resolved (work of Bessel van der Kolk for example). And I know mine get reactivated by 'endings' of any kind. It can leave me suicidal until I resurface. I'm working on it with a therapist.

So my cortisol of 620 whihch GP didn't comment on seems relatively low compared to 1000 plus.

So for me there is that explanation too as well as your apples and pears one.

I'm going to continue with the 4 capsules of Adrenavive 2 and in a few days start to add in the extra 25mcg of levo. I really didn't want to stop!

Re T3 are you saying that a drop when on replacement (monotherapy T4 in my case) can be an indication of a need for a raise? That's new to me. Does that mean that if T3 is relatively high compared to T4, that it means it's not getting into the cells? I'd like to understand a bit more if you're able.

Thanks again, I feel so relieved!🤗😃

[TiggerMe in reply to Sneedle]

That all sounds like a very likely trigger causing you to spike... she'll be back in no time with all the laundry 🤗

I'm not the best at explaining but in a nutshell.... (my understanding)

You take T4 which is a storage hormone which we test the availability as fT4 and relies on the right conditions to convert into fT3 which then circulates.. but this is also reliant on the right conditions to be absorbed into the cells where it actually does the business and cortisol is one of those factors, too much or too little can stop the cellular uptake...

So if you stay on the same dose of T4 and your fT4 stays constant but fT3 drops it seems likely that your fT3 cellular uptake has improved rather than your conversion worsening if your fT4 hasn't risen??

Told you I'm bad at the wordy explanations!

I'll call up tattybogle and radd who are vastly better than I 🤗

[Sneedle in reply to TiggerMe]

Thanks Eeyore yes that does make sense to me, you explained it fine!...I'm going to have to check now that I've been on the same dose of levo, my fog ain't helping! Very foggy here indeed today😁

[radd in reply to Sneedle]

Sneedle and TiggerMe

It isn’t directly the Adenavive that raises the cortisol but offers the supports to allow your body to make its own. As Eeyore has said blood serum measures the ‘total’ which is variable as influenced by trauma but also everyday occurrences such as sleep and changing blood glucose levels.

T3 and cortisols needs are bio-directional - as well as cortisol improving T3 activity, consider the way the adrenals supposedly respond during CT3M. FT3 levels are slightly variable but if conversion was to be unregulated by better levels of cortisol I would expect the FT3 level to remain fairly constant as the (deidinase) enzymes work in unison to help maintain both serum and intracellular thyroid hormone concentrations.

Therefore, any changes are carried through and adjustments made to the hormone transportation and those trnasporters that carry the T3 across the cell membrane to enter the cell to be metabolised by the deiodinase enzymes.

[TiggerMe in reply to radd]

Brilliant Radd thank you👏

[Sneedle in reply to radd]

Hi Radd and thanks for your explanation- I'm still trying to get my foggy head to understand it all.

It isn’t directly the Adenavive that raises the cortisol but offers the supports to allow your body to make its own.

I've read (I think) about not taking glandulars and/or hydrocortisone for example for a long time as this can encourage your adrenals to shut down thier production and become dependent. So what you're saying here is that Adrenavive doesn't do that?

So from what you say: if someone has low T3 and low cortisol, they both need supporting (by glandular for cortisol and T4 (in my case) or T3) so they can rise together with the least likelihood of adverse symptoms.

Oh blimey my head just won't do it - thank you for your reply and I will have to revisit the subject another time😜😃. I did look up Paul Robinson about T3 but got in a pickle there too as well!